coleonol | 64657-11-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: coleonol
• 英文别名: [(3R,4aR,5R,6S,6aS,10S,10aR,10bS)-3-ethenyl-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
• CAS: 64657-11-0
• 化学式: C₂₂H₃₄O₇
• 分子量: 410.508
• InChiKey: OHCQJHSOBUTRHG-WWVGWVLGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  29
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  coleonol 在 吡啶 、 氯化亚砜 、 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 反应 6.0h， 生成 Dehydrooxocoleonol
  参考文献：
  名称：

  Tandon, J. S.; Painuly, Prabha; Katti, S. B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 1, p. 67 - 69

  摘要：

  DOI：

文献信息

• Compositions and methods to effect enhanced photoprotection against UV A and UV B induced damage of human skin
  申请人：Majeed Muhammed

  公开号：US20080226571A1

  公开（公告）日：2008-09-18

  A composition based on labdane-diterpenoids that provides better photo protection against both UV A and UV B radiations in the HaCaT human keratinocyte cell lines is disclosed. The composition comprises 8,13-epoxy-1α,6β,7β,9α-tetrahydroxylabd-14-en-11-one alone and in combination with 6β-acetoxy-8,13-epoxy-1α,7β,9α-trihydroxylabd-14-en-11-one and/or 7β-acetoxy-8,13-epoxy-1α,6β,9α-trihydroxylabd-14-en-11-one. The composition protects the cells of the skin from harmful UV A and UV B rays through synergistic mechanisms with utility as a safe long-term cosmetic solution for preventing UV-induced skin damage and to induce sunless tanning. Additionally, the composition enhances melanogenesis in B16F1 mouse melanoma cells acting as tanning inducers/accelerators both in the presence or absence of sunlight. Elevation of melanogenesis confers additional protection against UV-induced skin damage.
• Tandon, J. S.; Painuly, Prabha; Katti, S. B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1984, vol. 23, # 1, p. 67 - 69
  作者：Tandon, J. S.、Painuly, Prabha、Katti, S. B.、Singh, Shyam

  DOI：——

  日期：——