2,2-bis(hydroxymethyl)-1,4-butanediol | 95461-66-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,2-bis(hydroxymethyl)-1,4-butanediol
• 英文别名: 2,2-bis-hydroxymethyl-butane-1,4-diol；2,2-Bis-hydroxymethyl-butan-1,4-diol；1,4-Butanediol, 2,2-bis(hydroxymethyl)-；2,2-bis(hydroxymethyl)butane-1,4-diol
• CAS: 95461-66-8
• 化学式: C₆H₁₄O₄
• 分子量: 150.175
• InChiKey: HBFBFJVRBIGLND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  80.9
• 氢给体数：
  4
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,2-bis(hydroxymethyl)-1,4-butanediol 在 甲醇 、 硝酸 、 sodium acetate 、 乙酸酐 、 barium methoxide 、 溶剂黄146 作用下， 生成 4-nitryloxy-3,3-bis-nitryloxymethyl-but-1-ene
  参考文献：
  名称：

  Notes- The Preparation of 2,2-Bis(hydroxymethyl)-2-methyl-3-butene-1-ol and Their Acetates and Nitrates

  摘要：

  DOI：

  10.1021/jo01089a614
• 作为产物：
  描述：

  聚合甲醛 、 4-羟基丁醛 在 水 、 sodium carbonate 作用下， 生成 2,2-bis(hydroxymethyl)-1,4-butanediol
  参考文献：
  名称：

  Notes- The Preparation of 2,2-Bis(hydroxymethyl)-2-methyl-3-butene-1-ol and Their Acetates and Nitrates

  摘要：

  DOI：

  10.1021/jo01089a614

文献信息

• METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIISOCYANATE
  申请人：Warsaw Orthopedic, Inc.

  公开号：US20150197488A1

  公开（公告）日：2015-07-16

  A method of making an amino acid triisocyanate is provided, the method comprising reacting an amino acid trihydrochloride with phosgene to form the amino acid triisocyanate. In some embodiments, the amino acid trihydrochloride comprises lysine ester trihydrochloride salt and the amino acid triisocyanate comprises lysine ester triisocyanate. In some embodiments, there is a lysine ester triisocyanate having a purity of at least about 98%, the lysine ester triisocyanate having a structure resulting from reacting lysine ester trihydrochloride salt with phosgene to form the lysine ester triisocyanate. These lysine ester triisocyanates can be used to make biodegradable polyurethanes.

  提供了一种制备氨基酸三异氰酸酯的方法，该方法包括将氨基酸三氢氯酸盐与光气反应以形成氨基酸三异氰酸酯。在一些实施例中，氨基酸三氢氯酸盐包括赖氨酸酯三氢氯酸盐，而氨基酸三异氰酸酯包括赖氨酸酯三异氰酸酯。在一些实施例中，存在一种纯度至少约为98%的赖氨酸酯三异氰酸酯，该赖氨酸酯三异氰酸酯具有由赖氨酸酯三氢氯酸盐与光气反应形成赖氨酸酯三异氰酸酯的结构。这些赖氨酸酯三异氰酸酯可用于制造生物降解聚氨酯。
• METHODS AND COMPOSITIONS FOR MAKING AN AMINO ACID TRIHYDROCHLORIDE
  申请人：Warsaw Orthopedic, Inc.

  公开号：US20150197483A1

  公开（公告）日：2015-07-16

  In some embodiments, a method of making an amino acid trihydrochloride is provided, the method comprising reacting an amino acid monohydrochloride with an alkanolamine to form the amino acid trihydrochloride. In some embodiments, the amino acid monohydrochloride comprises lysine hydrochloride, which is mixed with ethanolamine to form lysine ester trihydrochloride. In some embodiments, there is a lysine ester trihydrochloride salt having a purity of at least about 98%, the lysine ester trihydrochloride salt having a structure resulting from reacting lysine hydrochloride and ethanolamine to form the lysine ester trihydrochloride salt. The lysine ester trihydrochloride can be made in one reaction vessel.

  在某些实施例中，提供了一种制备氨基酸三氢氯化物的方法，该方法包括将氨基酸单氢氯化物与烷醇胺反应以形成氨基酸三氢氯化物。在某些实施例中，氨基酸单氢氯化物包括赖氨酸盐酸盐，其与乙醇胺混合以形成赖氨酸酯三氢氯化物。在某些实施例中，存在一种纯度至少约98%的赖氨酸酯三氢氯化物盐，该赖氨酸酯三氢氯化物盐具有由赖氨酸盐酸盐和乙醇胺反应形成赖氨酸酯三氢氯化物盐的结构。赖氨酸酯三氢氯化物可以在一个反应容器中制造。
• FLUORENE COMPOUND
  申请人：TAKAHASHI Daisuke

  公开号：US20100240867A1

  公开（公告）日：2010-09-23

  Particular compounds having a fluorene skeleton are superior in broad utility and stability, as a protecting reagent for liquid phase synthesis of amino acids and/or peptides.

  具有芴骨架的特定化合物在广泛的应用和稳定性方面优越，作为氨基酸和/或肽液相合成的保护试剂。
• Synthesis of new unsymmetrical optically active (s)-(+)-naproxen dendrimers
  作者：Srinagesh Kumar Potluri、A. Raghu Ramulu、M. Pardhasaradhi

  DOI：10.1016/j.tet.2004.09.033

  日期：2004.11

  new unsymmetrical optically active (s)-(+)-naproxen dendrimers containing 2-hydroxymethyl-1,4-butanediol and 2,2-bis(hydroxymethyl)-1,4-butanediol cores is described. These polyarylester dendrimers are unsymmetrical with respect to chain lengths and aid in studying controlled drug delivery based on differential enzymatic cleavage. Synthesis of a new acid dendritic wedge containing (s)-(+)-naproxen is

  描述了含有2-羟甲基-1,4-丁二醇和2,2-双（羟甲基）-1,4-丁二醇核的新型不对称旋光（s）-（+）-萘普生树状聚合物的制备。这些聚芳基酯树枝状聚合物在链长方面是不对称的，并有助于研究基于差异酶切的受控药物递送。还报道了含有（s）-（+）-萘普生的新的酸性树枝状楔的合成。
• Compositions for tissue augmentation
  申请人：Kuros Biosurgery AG

  公开号：US20030232944A1

  公开（公告）日：2003-12-18

  Methods for making biomaterials for augmentation of soft and hard tissues, kits containing precursors for forming the biomaterials, and the resulting biomaterials are described herein. The biomaterials are formed from at least a first and a second precursor component. The first precursor component contains at least two nucleophilic groups, and the second precursor component contains at least two electrophilic groups. The nucleophilic and electrophilic groups of the first and second precursor components form covalent linkages with each other at physiological temperatures. The precursors are selected based on the desired properties of the biomaterial. In the preferred embodiment, the first precursor is a siloxane. Optionally, the biomaterials contain additives, such as thixotropic agents, radiopaque agents, or bioactive agents. In the preferred embodiment, the biomaterials are used to augment at least one vertebra of the spine (vertebroplasty).

  本文描述了用于增强软组织和硬组织的生物材料制备方法，包含形成生物材料的前体物质的套件以及所得到的生物材料。生物材料由至少第一和第二前体成分形成。第一前体成分含有至少两个亲核基团，第二前体成分含有至少两个电子亲和基团。第一和第二前体成分的亲核和电子亲和基团在生理温度下形成共价键。前体物质根据所需的生物材料性质进行选择。在首选实施例中，第一前体是硅氧烷。可选地，生物材料包含添加剂，例如流变剂、放射性不透明剂或生物活性剂。在首选实施例中，生物材料用于增强脊柱的至少一个椎体（椎体成形术）。