毒理性
◉ 母乳喂养期间使用总结：目前没有关于在母乳喂养期间服用镁醋酸镁后镁的排泄情况的信息。然而，已经对其他镁盐进行了研究。静脉注射硫酸镁仅略微增加了乳汁中镁的浓度。婴儿对镁的口服吸收不良，因此母亲服用的镁醋酸镁不太可能影响母乳喂养婴儿的血清镁。在怀孕期间补充镁醋酸镁可能会延迟哺乳的开始，但在母乳喂养期间可以服用，不需要特别的预防措施。
◉ 对母乳喂养婴儿的影响：50位处于产后的第一天母亲接受了15毫升的矿物油或矿物油和另一种镁盐的乳液，即相当于900毫克氢氧化镁的氢氧化镁，尽管没有说明确切的接受每种产品的人数。如果需要，在随后的几天里可以给予额外的剂量。没有注意到接受母乳喂养的婴儿有任何明显异常的大便，但所有婴儿也接受了补充喂养。
◉ 对哺乳和母乳的影响：一位因妊娠期高血压接受3天静脉注射硫酸镁的母亲，哺乳II期延迟到产后第10天。没有找到延迟的其他具体原因，尽管没有进行完整的检查。随后的对照临床试验发现，接受静脉注射硫酸镁治疗的母亲没有延迟哺乳的证据。一些，但不是所有的研究发现，接受静脉注射硫酸镁治疗的母亲所生的婴儿首次喂养时间延长或吸吮减少的趋势，因为镁通过胎盘传递给胎儿。
在一项对40对健康女性进行的研究中，这些女性通过阴道分娩单胎妊娠，比较了在分娩前至少4周接受连续口服镁醋酸镁HCl补充剂（平均剂量为459毫克/天，范围365至729毫克/天镁）的组与对照组的结果终点。在镁组中，能够在出院时仅通过母乳喂养婴儿的女性显著较少（63%对80%）。
◉ Summary of Use during Lactation:No information is available on the excretion of magnesium following magnesium aspartate during breastfeeding. However, other magnesium salts have been studied. Intravenous magnesium sulfate increases milk magnesium concentrations only slightly. Oral absorption of magnesium by the infant is poor, so maternal magnesium aspartate is not expected to affect the breastfed infant's serum magnesium. Magnesium aspartate supplementation during pregnancy might delay the onset of lactation, but it can be taken during breastfeeding and no special precautions are required.
◉ Effects in Breastfed Infants:Fifty mothers who were in the first day postpartum received 15 mL of either mineral oil or an emulsion of mineral oil and another magnesium salt, magnesium hydroxide equivalent to 900 mg of magnesium hydroxide, although the exact number who received each product was not stated. Additional doses were given on subsequent days if needed. None of the breastfed infants were noted to have any markedly abnormal stools, but all of the infants also received supplemental feedings.
◉ Effects on Lactation and Breastmilk:One mother who received intravenous magnesium sulfate for 3 days for pregnancy-induced hypertension had lactogenesis II delayed until day 10 postpartum. No other specific cause was found for the delay, although a complete work-up was not done. A subsequent controlled clinical trial found no evidence of delayed lactation in mothers who received intravenous magnesium sulfate therapy. Some, but not all, studies have found a trend toward increased time to the first feeding or decreased sucking in infants of mothers treated with intravenous magnesium sulfate during labor because of placental transfer of magnesium to the fetus.
A study in 40 pairs of matched healthy women with vaginally delivered singleton pregnancies, outcome endpoints were compared in those receiving continuous oral magnesium aspartate HCl supplementation mean dose of 459 mg daily (range 365 to 729 mg of magnesium daily) for at least 4 weeks before delivery versus non-supplemented controls. In the magnesium group, significantly fewer women could breastfeed their infants exclusively at discharge (63% vs 80%).
来源:Drugs and Lactation Database (LactMed)
