Nystatin A1 | 34786-70-4

• 物质功能分类: 原料药 - 抗生素类药物 - 多烯类药
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: Nystatin A1
• 英文别名: nystatin；(1S,3R,4R,7R,9R,11R,15S,16R,17R,18S,19E,21E,25E,27E,29E,31E,33R,35S,36R,37S)-33-[(3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy-1,3,4,7,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,25,27,29,31-hexaene-36-carboxylic acid
• CAS: 34786-70-4
• 化学式: C₄₇H₇₅NO₁₇
• 分子量: 926.109
• InChiKey: VQOXZBDYSJBXMA-KIZJZLKASA-N

物化性质

• 熔点：
  >300°C
• 沸点：
  1132.2±65.0 °C(Predicted)
• 密度：
  1.33±0.1 g/cm3(Predicted)
• 溶解度：
  可溶于DMSO（轻微）、甲醇（轻微、超声处理）、吡啶（轻微）

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  65
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  320
• 氢给体数：
  12
• 氢受体数：
  18

安全信息

• 海关编码：
  2942000000
• 储存条件：
  2-8℃

制备方法与用途

化学性质
淡黄色粉末。含有A₁、A₂和A₃三种生物活性成分，还原性较强。悬浮液在pH值7.0时，在100℃下能稳定保持10分钟；光、热、氧会加速其分解；无熔点，加热至160℃以上开始分解。其比旋光度分别为：[α]²⁵D+21°（吡啶）、+12°（二甲基甲酰胺）、-7°（0.1mol/L盐酸的甲醇溶液）和-10°（冰乙酸）。该物质在乙醇中的最大吸收波长为290nm、307nm和322nm。常温下的溶解度如下：水4mg/ml、甲醇11.2mg/ml、乙醇1.2mg/ml、乙二醇8.75 mg/ml、四氯化碳1.23mg/ml、氯仿0.48mg/ml、苯0.28mg/ml。其半数致死量（小鼠，腹腔注射）约为200mg/kg。

用途
用于生化研究，作为高纯细胞培养的防腐剂，并具有抗霉菌作用。

生产方法
通过Streptomyces noursei菌株培养液过滤取菌丝，在50-60℃真空干燥后，用甲醇提取，除去溶剂后干燥获得。

文献信息

• SUSTAINED RELEASE COMPOSITION USING BIOBASED BIODEGRADABLE HYPERBRANCHED POLYESTERS
  申请人：MICHIGAN MOLECULAR INSTITUTE

  公开号：US20170073465A1

  公开（公告）日：2017-03-16

  The present invention provides a sustained release composition having hyperbranched polymers that are polyesters that are biobased and biodegradable, and that have at least one active ingredient, which composition delivers the active ingredient over time. These active ingredients can be a wide variety of compounds so long as they can covalently bind to the polymer or be encapsulated in the polymer in a manner that is released at the point of delivery, usually by acid hydrolysis or enzymatic bond scission.
• [EN] SUSTAINED RELEASE COMPOSITION USING BIOBASED BIODEGRADABLE HYPERBRANCHED POLYESTERS<br/>[FR] COMPOSITION À LIBÉRATION PROLONGÉE UTILISANT DES POLYESTERS HYPERRAMIFIÉS BIODÉGRADABLES D'ORIGINE BIOLOGIQUE
  申请人：MICHIGAN MOLECULAR INST

  公开号：WO2015130602A2

  公开（公告）日：2015-09-03

  The present invention provides a sustained release composition having hyperbranched polymers that are polyesters that are biobased and biodegradable, and that have at least one active ingredient, which composition delivers the active ingredient over time. These active ingredients can be a wide variety of compounds so long as they can covalently bind to the polymer or be encapsulated in the polymer in a manner that is released at the point of delivery, usually by acid hydrolysis or enzymatic bond scission.