N-[(3R,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide | 72-87-7

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-[(3R,5S)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]acetamide
• CAS: 72-87-7；1136-42-1；1136-44-3；6082-29-7；6730-06-9；7772-94-3；10036-64-3；14131-60-3；14131-64-7；14131-68-1；14215-68-0；62057-49-2；62057-50-5；62057-51-6；62057-52-7；62057-53-8；62057-54-9；62057-55-0；62057-56-1；62075-50-7；62137-54-6；134451-97-1；134522-12-6；148347-16-4
• 化学式: C₈H₁₅NO₆
• 分子量: 221.21
• InChiKey: OVRNDRQMDRJTHS-DMIPUTKBSA-N

物化性质

• 熔点：
  211 °C
• 沸点：
  595.4±50.0 °C(Predicted)
• 密度：
  1.50
• LogP：
  -2.314 (est)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.7
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  119
• 氢给体数：
  5
• 氢受体数：
  6

制备方法与用途

该化合物2-乙酰氨基-2-脱氧-α-D-吡喃葡萄糖主要用于科研。

文献信息

• Substituted Imidazole 4-Carboxamides as Cholecystokinin-1 Receptor Modulators
  申请人：Berger Richard

  公开号：US20090118300A1

  公开（公告）日：2009-05-07

  Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R, such as obesity, and diabetes.

  某些新型取代咪唑4-羧酰胺是人类胆囊收缩素受体的配体，特别是人类胆囊收缩素-1受体（CCK-1R）的选择性配体。因此，它们可用于治疗、控制或预防对CCK-1R调节敏感的疾病和疾病，如肥胖症和糖尿病。
• SUBSTITUTED IMIDAZOLE 4-CARBOXAMIDES AS CHOLECYSTOKININ-1 RECEPTOR MODULATORS
  申请人：Berger Richard

  公开号：US20100311649A1

  公开（公告）日：2010-12-09

  Certain novel substituted imidazole 4-carboxamides are ligands of the human cholecystokinin receptor and, in particular, are selective ligands of the human cholecystokinin-1 receptor (CCK-1R). They are therefore useful for the treatment, control, or prevention of diseases and disorders responsive to the modulation of CCK-1R , such as obesity, and diabetes.

  某些新型取代咪唑-4-羧酰胺是人胆囊收缩素受体的配体，特别是人胆囊收缩素-1受体(CCK-1R)的选择性配体。因此，它们可用于治疗、控制或预防对CCK-1R调节敏感的疾病和障碍，如肥胖和糖尿病。
• CHEMOENZYMATIC SYNTHESIS OF HEPARIN AND HEPARAN SULFATE ANALOGS
  申请人：The Regents of the University of California

  公开号：US20170016040A1

  公开（公告）日：2017-01-19

  The present invention provides a one-pot multi-enzyme method for preparing UDP-sugars from simple sugar starting materials. The invention also provides a one-pot multi-enzyme method for preparing oligosaccharides from simple sugar starting materials.
• US7795265B2
  申请人：——

  公开号：US7795265B2

  公开（公告）日：2010-09-14
• US7977339B2
  申请人：——

  公开号：US7977339B2

  公开（公告）日：2011-07-12