1-(3-hydroxypropyl)-cyclohexanol | 6963-45-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(3-hydroxypropyl)-cyclohexanol
• 英文别名: 1-hydroxy-1-cyclohexane-propanol；1-(3-hydroxypropyl)cyclohexanol；1-(3-Hydroxy-propyl)-cyclohexanol；n-propanol,cyclohexanol；3-(1-Hydroxycyclohexyl)-1-propanol；3-(1-Hydroxy-cyclohexyl)-propanol；1-(3-hydroxypropyl)cyclohexan-1-ol
• CAS: 6963-45-7
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: KCENFBLAEKHLPA-UHFFFAOYSA-N

物化性质

• 沸点：
  117 °C(Press: 2 Torr)
• 密度：
  1.031±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1-(3-hydroxypropyl)-cyclohexanol 在 吡啶 、 氢氧化钾 、 氯化亚砜 、 水 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 2.75h， 生成 3-(cyclohex-1-en-yl)propan-1-ol
  参考文献：
  名称：

  用于合成 (±)-Pumiliotoxin C 及其类似物的高级中间体

  摘要：

  摘要 化合物 1 作为合成 (±)-pumiliotoxin C 及其类似物的通用中间体是从市售的环己酮中制备的。合成的关键步骤是通过立体选择性氨基环化构建八氢喹啉环。

  DOI：

  10.1081/scc-120037916
• 作为产物：
  描述：

  原白头翁素 在 palladium on activated charcoal 锂硼氢 、 氢气 、 对苯二酚 作用下， 以 四氢呋喃 为溶剂， 25.0~155.0 ℃ 、202.65 kPa 条件下， 反应 40.0h， 生成 1-(3-hydroxypropyl)-cyclohexanol
  参考文献：
  名称：

  General synthesis of 1-oxaspiro[4.5]decan-2-ones and 1-oxaspiro[4.5]decanes from 5-methylene-2(5H)-furanone

  摘要：

  5-Methylene-2(5H)-furanone underwent Diels-Alder cycloadditions to butadiene and several acyclic and cyclic C-substituted dienes, respectively, affording bicyclic and tricyclic spiroadducts in good yields. These compounds are precursors of other unsaturated and saturated spirolactones and also spiroethers, which were obtained through simple chemical reactions, i.e., hydrogenation of C-C double bonds, reduction of the carbonyl group, and Michael addition. The synthesis of 32 spirolactones and eight spiroethers illustrates the scope and efficiency of this method. Many of these products are suitable for use as components of perfumes and aromas owing to their olfactive properties.

  DOI：

  10.1021/jo00019a019

文献信息

• [EN] CONDENSED PYRIDINES AND PYRIMIDINES WITH TIE2 (TEK) ACTIVITY<br/>[FR] PYRIDINES CONDENSEES ET PYRIMIDINES A ACTIVITE TIE2 (TEK)
  申请人：ASTRAZENECA AB

  公开号：WO2004013141A1

  公开（公告）日：2004-02-12

  A compound of the Formula (I), wherein A together with the carbon atoms to which it is attached forms a fused 5-membered heteroaryl ring, wherein said heteroaryl ring contains 1 or 2 heteroatoms selected from O, N and S, and wherein the 5-membered ring containing G is linked to the ring formed by A in the meta position to the bridgehead carbon marked # in Formula (I); G is selected from O, S and NR5; Z is selected from N and CR6; Q1 is selected from optionally substituted aryl and heteroaryl, and the substituents R1 to R6 are as defined in the text for use in the production of an anti-angiogenic effect in a warm blooded animal such as man.

  化合物的公式（I），其中A与其连接的碳原子一起形成一个融合的5-成员杂环芳烃环，其中所述的杂环芳烃环包含1个或2个从O、N和S中选择的杂原子，并且包含G的5-成员环与在公式（I）中标记为桥头碳#的A形成的环在间位连接；G从O、S和NR5中选择；Z从N和CR6中选择；Q1从可选择的取代芳基和杂环芳基中选择，取代基R1到R6如文本中所定义，用于在温血动物（如人）中产生抗血管生成作用。
• Internal release agent, composition including internal release agent, and process for producing a plastic lens using same composition
  申请人：MITSUI CHEMICALS, INC.

  公开号：US10239239B2

  公开（公告）日：2019-03-26

  An internal release agent includes at least one phosphodiester represented by the following general formula (1). In the formula, R1 and R2 independently represent a hydrocarbon group having 1 to 30 carbon atoms, which is optionally substituted with at least one hydroxyl group, and R3 represents an alkylene group having 2 to 4 carbon atoms. A plurality of R3's may be the same as or different from each other. M represents a hydrogen atom, an ammonium ion, an alkali metal ion, or a monovalent/divalent alkali earth metal ion, and n is an integer of 1 to 60.

  内部释放剂至少包括一个由以下一般式（1）表示的磷酸二酯。在该式中，R1和R2分别表示具有1至30个碳原子的烃基，该烃基可以选择性地取代至少一个羟基，而R3表示具有2至4个碳原子的烷基基团。多个R3可以相同或者彼此不同。M代表氢原子、铵离子、碱金属离子或者一价/二价碱土金属离子，n为1至60的整数。
• Intramolecular Cyclization of 3,4-Epoxy Alcohols; Oxetane Formation
  作者：Akio Murai、Mitsunori Ono、Tadashi Masamune

  DOI：10.1246/bcsj.50.1226

  日期：1977.5

  1-(2,3-Epoxypropyl)-1-cyclohexanol (1) and its methyl analogues (2 and 3), when treated with base in 75% aqueous dimethyl sulfoxide, gave the corresponding oxetanes (9–11) as the main products, while treatment of compound 1 under anhydrous conditions afforded the oxolane dimer (17) as the sole identified product.

  1-(2,3-环氧丙基)-1-环己醇 (1) 及其甲基类似物 (2 和 3)，当在 75% 二甲亚砜水溶液中用碱处理时，得到相应的氧杂环丁烷 (9-11) 作为主要产物，而在无水条件下处理化合物 1 得到 oxolane 二聚体 (17) 作为唯一确定的产物。
• Synthese de composes dihydro-2,3 furanniques par hydroboration d'alcools β-acetyleniques
  作者：Gilbert Dana、Bruno Figadère、Estera Touboul

  DOI：10.1016/s0040-4039(01)80919-9

  日期：1985.1

  Hydroboration of β-acetylenic alcohols followed by NaOH/H2O2 oxidation leads to hemiacetals of γ-aldols which are easily dehydrated to 2,3-dihydrofuran compounds. The reaction gives good yields with hindered alcohols and its stereochemistry may be controlled during the organometallic synthesis of the starting alcohol.

  β-炔醇的硼氢化反应，然后进行NaOH / H 2 O 2氧化，导致生成的γ-醛缩醛半缩醛容易脱水成2,3-二氢呋喃化合物。该反应在受阻醇的作用下具有良好的收率，并且可以在起始醇的有机金属合成过程中控制其立体化学。
• [EN] THERAPEUTIC AGENTS<br/>[FR] AGENTS THERAPEUTIQUES
  申请人：ASTRAZENECA AB

  公开号：WO2004058776A1

  公开（公告）日：2004-07-15

  A compound of the Formula: (I) (A chemical formula should be inserted here-please see paper copy enclosed herewith) Formula: (I); for use as a Tie2 receptor tyrosine kinase inhibitor in a warm-blooded animal such as man.

  一种化合物的化学式：（I）（这里应插入化学式，请参见附带的纸质副本）化学式：（I）；用作在温血动物（如人类）中的Tie2受体酪氨酸激酶抑制剂。