(-)-4-O-(tert-butyldimethylsilyl)podophyllotoxin | 112711-16-7
分子结构分类
中文名称
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中文别名
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英文名称
(-)-4-O-(tert-butyldimethylsilyl)podophyllotoxin
英文别名
tert-butyldimethylsilylpodophyllotoxin；(5R,5aR,8aR,9R)-9-((tert-butyldimethylsilyl)oxy)-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6(5aH)-one；(5R,5aR,8aR,9R)-5-[tert-butyl(dimethyl)silyl]oxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[5,6-f][1,3]benzodioxol-8-one；(5R,5aR,8aR,9R)-5-[tert-butyl(dimethyl)silyl]oxy-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one
CAS
112711-16-7
化学式
C28H36O8Si
mdl
——
分子量
528.675
InChiKey
RKDMQBDZYQYJGX-PVUOONDNSA-N
BEILSTEIN
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EINECS
——
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物化性质
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计算性质
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ADMET
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安全信息
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SDS
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制备方法与用途
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上下游信息
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文献信息
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表征谱图
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同类化合物
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相关功能分类
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相关结构分类
物化性质
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沸点：590.5±50.0 °C(Predicted)
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密度：1.23±0.1 g/cm3(Predicted)
计算性质
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辛醇/水分配系数(LogP)：5.44
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重原子数：37
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可旋转键数：7
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环数：5.0
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sp3杂化的碳原子比例：0.54
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拓扑面积：81.7
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氢给体数：0
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氢受体数：8
上下游信息
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上游原料
中文名称 英文名称 CAS号 化学式 分子量 —— (+)-4-O-(tert-butyldimethylsilyl)picropodophyllin 108448-52-8 C28H36O8Si 528.675 鬼臼毒素 podofilox 518-28-5 C22H22O8 414.412 苦鬼臼毒素 picropodophyllotoxin 477-47-4 C22H22O8 414.412 —— (-)-3-(hydroxymethyl)picropodophyllone 117179-02-9 C23H22O9 442.422 (5R)-5,8,8ab,9-四氢-5b-(3,4,5-三甲氧基苯基)呋喃并[3',4':6,7]萘并[2,3-d]-1,3-二氧杂环戊烯-6(5abH),9-二酮 (5aR,8aS,9R)-9-(3,4,5-trimethoxyphenyl)-5a,6,8a,9-tetrahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxole-5,8-dione 477-48-5 C22H20O8 412.396 —— beta-Apopicropodophyllin 477-52-1 C22H20O7 396.397 -
下游产品
中文名称 英文名称 CAS号 化学式 分子量 —— (+)-4-O-(tert-butyldimethylsilyl)picropodophyllin 108448-52-8 C28H36O8Si 528.675 —— methyl (5R,6S,7R,8R)-8-[tert-butyl(dimethyl)silyl]oxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole-6-carboxylate 303958-09-0 C29H40O9Si 560.717 —— (5R,6S,7R,8R)-8-[tert-butyl(dimethyl)silyl]oxy-7-(hydroxymethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole-6-carboxylic acid 303958-06-7 C28H38O9Si 546.69 —— (5R,5aS,8aS,9R)-9-(tert-Butyl-dimethyl-silanyloxy)-8-hydroxy-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 303958-07-8 C28H36O9Si 544.674 —— (5R,6S,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-7-formyl-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 303958-08-9 C29H38O9Si 558.701 —— (5R,6S,7S,8R)-8-(tert-Butyl-dimethyl-silanyloxy)-5-(3,4,5-trimethoxy-phenyl)-7-vinyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 303958-14-7 C30H40O8Si 556.728 鬼臼毒素 podofilox 518-28-5 C22H22O8 414.412 —— (5R,5aR,8aS,9R)-5-[tert-butyl(dimethyl)silyl]oxy-8a-fluoro-9-(3,4,5-trimethoxyphenyl)-5,5a,6,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-8-one 223777-99-9 C28H35FO8Si 546.665 —— (5R,5aR,8aR,9R)-9-hydroxy-5a-prop-2-enyl-5-(3,4,5-trimethoxyphenyl)-5,8,8a,9-tetrahydro-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one 178101-50-3 C25H26O8 454.477 —— picropodophyllin homolactone 98369-20-1 C23H24O8 428.439 —— (5R,6S,7S,8S)-8-Hydroxy-7-(2-hydroxy-ethyl)-5-(3,4,5-trimethoxy-phenyl)-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 303958-13-6 C24H28O9 460.481 —— methyl (5R,6S,7S,8R)-8-hydroxy-7-(2-hydroxyethyl)-5-(3,4,5-trimethoxyphenyl)-5,6,7,8-tetrahydrobenzo[f][1,3]benzodioxole-6-carboxylate 303958-16-9 C24H28O9 460.481 —— (5R,6S,7S,8R)-8-Hydroxy-5-(3,4,5-trimethoxy-phenyl)-7-vinyl-5,6,7,8-tetrahydro-naphtho[2,3-d][1,3]dioxole-6-carboxylic acid methyl ester 303958-15-8 C24H26O8 442.466 —— 2-fluoropodophyllotoxin 223778-03-8 C22H21FO8 432.402 —— (5S,5aR,8aS,9R)-8a-fluoro-5-hydroxy-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5,5a,6,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-8-one —— C21H19FO8 418.375 —— methyl (3aS,4S,5R,10bS)-2-hydroxy-5-(3,4,5-trimethoxyphenyl)-2,3,3a,4,5,10b-hexahydro-[1]benzofuro[6,7-f][1,3]benzodioxole-4-carboxylate 303958-11-4 C24H26O9 458.465 —— (5R,5aR,8aS,9S)-5a-Allyl-9-azido-5-(3,4,5-trimethoxy-phenyl)-5,8,8a,9-tetrahydro-5aH-furo[3',4':6,7]naphtho[2,3-d][1,3]dioxol-6-one 178101-53-6 C25H25N3O7 479.489 —— (5S,5aS,8aS,9R)-5-(4-aminoanilino)-8a-fluoro-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5,5a,6,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-8-one —— C27H25FN2O7 508.503 —— (5S,5aS,8aS,9R)-8a-fluoro-5-(4-fluoroanilino)-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5,5a,6,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-8-one —— C27H23F2NO7 511.479 —— 4-[[(5S,5aS,8aS,9R)-8a-fluoro-9-(4-hydroxy-3,5-dimethoxy-phenyl)-8-oxo-5,5a,6,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-5-yl]amino]benzonitrile —— C28H23FN2O7 518.498 —— 4β-(3'',4''-(ethylenedioxy)anilino)-4''-O-demethyl-2-fluoropodophyllotoxin —— C29H26FNO9 551.525 —— (5S,5aS,8aS,9R)-8a-fluoro-9-(4-hydroxy-3,5-dimethoxy-phenyl)-5-(4-nitroanilino)-5,5a,6,9-tetrahydroisobenzofuro[5,6-f][1,3]benzodioxol-8-one 342824-63-9 C27H23FN2O9 538.486 —— 4β-N-(2",4"-dimethoxyphenylsulfonylurea)-4-deoxyanhydroepipodophyllotoxin 1531622-94-2