申请人:Lutonix, Inc.
公开号:US10835719B2
公开(公告)日:2020-11-17
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent, an antioxidant, and an additive. In certain embodiments, the additive has a hydrophilic part and a drug affinity part, wherein the drug affinity part is at least one of a hydrophobic part, a part that has an affinity to the therapeutic agent by hydrogen bonding, and a part that has an affinity to the therapeutic agent by van der Waals interactions. In some embodiments, the additive is a liquid. In other embodiments, the additive is at least one of a surfactant and a chemical compound, and the chemical compound has one or more hydroxyl, amino, carbonyl, carboxyl, acid, amide or ester groups.
本发明涉及一种向组织输送治疗剂的医疗器械。该医疗器械的外表面覆盖有一层。该层包含治疗剂、抗氧化剂和添加剂。在某些实施例中,添加剂具有亲水性部分和药物亲和性部分,其中药物亲和性部分是疏水性部分、通过氢键与治疗剂具有亲和性的部分和通过范德华相互作用与治疗剂具有亲和性的部分中的至少一种。在某些实施方案中,添加剂是液体。在其他实施方案中,添加剂是表面活性剂和化合物中的至少一种,化合物具有一个或多个羟基、氨基、羰基、羧基、酸、酰胺或酯基。