Neo Heliopan AP Sodium Salt | 180898-37-7

• 物质功能分类: 有机原料 - 杂环化合物
• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: Neo Heliopan AP Sodium Salt
• CAS: 180898-37-7
• 化学式: C20H14N4NaO12S4
• 分子量: 653.6
• InChiKey: YCWCJGXHELVZPI-UHFFFAOYSA-N

物化性质

• 密度：
  1.82[at 20℃]
• LogP：
  -2 at 23℃

计算性质

• 辛醇/水分配系数(LogP)：
  1.38
• 重原子数：
  41
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  308
• 氢给体数：
  6
• 氢受体数：
  14

文献信息

• Use of aryl oximes for the prophylaxis and/or treatment of erythema formation and/or inflammatory reaction of the skin
  申请人：——

  公开号：US20030157037A1

  公开（公告）日：2003-08-21

  The present invention relates to the use of at least one aryl oxime of Formula (I). 1 wherein: Y, Z represent independently from each other H, C 1-18 alkyl, C 2-18 alkenyl, C 2-18 carboxy alkyl, C 3-18 carboxy alkenyl or C 2-18 alkanoyl; R represents C 1-18 alkyl, C 2-18 alkenyl, C 3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R 1 , R 2 , R 3 and R 4 represent independently from each other H, C 1-12 alkyl, C 2-12 alkenyl, C 1-12 alkoxy, C 3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl, for the prophylaxis and/or treatment of erythema formation and/or inflammation responses of the skin.

  本发明涉及至少一种具有以下式(I)的芳基羟肟的用途。 其中： Y，Z分别独立于H，C1-18烷基，C2-18烯烃基，C2-18羧基烷基，C3-18羧基烯烃基或C2-18酰基； R代表C1-18烷基，C2-18烯烃基，C3-8环烷基，芳基，芳基烷基，杂环芳基，杂环芳基烷基或缩合体； R1，R2，R3和R4分别独立于H，C1-12烷基，C2-12烯烃基，C1-12烷氧基，C3-8环烷氧基，芳基，芳氧基，芳基烷基，杂环芳基，杂环芳基烷基，羧基，羟基，氯，二烷基胺或磺酰基； 用于预防和/或治疗皮肤红斑形成和/或炎症反应。
• Topical composition containing at least one aryl oxime, and method for the preparation thereof
  申请人：——

  公开号：US20030176470A1

  公开（公告）日：2003-09-18

  The present invention relates to a topical composition, comprising (c) at least one aryl oxime of the Formula (I) and (d) at least one emulsifier, 1 wherein: Y, Z represent independently from each other H, C 1-18 alkyl, C 2-18 alkenyl, C 2-18 carboxy alkyl, C 3-18 carboxy alkenyl or C 2-18 alkanoyl; R represents C 1-18 alkyl, C 2-18 alkenyl, C 3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R 1 , R 2 , R 3 and R 4 represent independently from each other H, C 1-12 alkyl, C 2-12 alkenyl, C 1-12 alkoxy, C 3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl, wherein the component (b) is selected from the group consisting of an ester, the carboxylic acid residue of which is derived from C 5 -C 16 acids and the hydroxyl residue of which is derived from monomers, dimers or trimers of lactic acid or one of its salts or a polyglycerin of 2 to 10 molecules of glycerin whereby 1 to 3 moles of carboxylic acid are present per mole of polyglycerin. Furthermore, the present invention relates to a process for the preparation of said topical composition as well as the use of said topical composition.

  本发明涉及一种局部组合物，包括(c)至少一种式(I)的芳基肟和(d)至少一种乳化剂，其中：Y、Z各自独立地表示H、C1-18烷基、C2-18烯基、C2-18羧基烷基、C3-18羧基烯基或C2-18烷酰基；R表示C1-18烷基、C2-18烯基、C3-8环烷基、芳基、芳基烷基、杂环芳基、杂环芳基烷基或缩合体；R1、R2、R3和R4各自独立地表示H、C1-12烷基、C2-12烯基、C1-12烷氧基、C3-8环烷氧基、芳基、芳氧基、芳基烷基、杂环芳基、杂环芳基烷基、羧基、羟基、氯、二烷基胺或磺酰基，其中组分(b)选自由C5-C16酸衍生的酯的羧基残基以及由乳酸单体、二聚体或三聚体或其盐衍生的羟基残基或2至10分子甘油的聚甘油，其中每个聚甘油分子中存在1至3摩尔羧酸。此外，本发明还涉及一种制备该局部组合物的方法以及使用该局部组合物的用途。
• Composition containing at least one aryl oxime and at least one active substance for treating acne and the use thereof
  申请人：——

  公开号：US20030187034A1

  公开（公告）日：2003-10-02

  The present invention relates to a composition, comprising (a) at least one aryl oxime of Formula (I) and (b) at least one active agent for the treatment of acne 1 wherein: Y, Z represent independently from each other H, C 1-18 alkyl, C 2-18 alkenyl, C 2-18 carboxy alkyl, C 3-18 carboxy alkenyl or C 2-18 alkanoyl; R represents C 1-18 alkyl, C 2-18 alkenyl, C 3-8 cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl or condensed systems; R 1 , R 2 , R 3 and R 4 represent independently from each other H, C 1-12 alkyl, C 2-12 alkenyl, C 1-12 alkoxy, C 3-8 cycloalkoxy, aryl, aryloxy, aralkyl, heteroaryl, heteroaralkyl, carboxy, hydroxy, chlorine, dialkyl amine or sulfonyl. Moreover, the present invention relates to the use of this composition as well as the use of the aforementioned aryl oxime of Formula (I).

  本发明涉及一种组合物，包括（a）公式（I）中的至少一种芳基肟和（b）用于治疗痤疮的至少一种活性剂，其中：Y、Z分别独立地表示H、C1-18烷基、C2-18烯基、C2-18羧基烷基、C3-18羧基烯基或C2-18酰基；R表示C1-18烷基、C2-18烯基、C3-8环烷基、芳基、芳基烷基、杂芳基、杂芳基烷基或缩合体；R1、R2、R3和R4独立地表示H、C1-12烷基、C2-12烯基、C1-12烷氧基、C3-8环烷氧基、芳基、芳氧基、芳基烷基、杂芳基、杂芳基烷基、羧基、羟基、氯、二烷基胺或磺酰基。此外，本发明涉及该组合物的使用以及上述公式（I）中的芳基肟的使用。
• Skin model
  申请人：Symrise GmbH & Co. KG

  公开号：EP1927656A1

  公开（公告）日：2008-06-04

  The present invention relates to the use of a pig skin sample as a skin model, particularly for the assessment of pharmacological and cosmetic effects.

  本发明涉及使用猪皮肤样本作为皮肤模型，特别是用于评估药理和美容效果。
• Ex vivo human skin model
  申请人：Symrise GmbH & Co. KG

  公开号：EP2019316A2

  公开（公告）日：2009-01-28

  The present invention relates to the use of an ex vivo human skin sample as a biological model, particularly for the assessment of pharmacological and cosmetic effects.

  本发明涉及使用体外人体皮肤样本作为生物模型，特别是用于评估药理和美容效果。