阿苯达唑杂质L | 108579-67-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 中文名称: 阿苯达唑杂质L
• 英文名称: Methiazole
• 英文别名: methyl N-(6-propan-2-ylsulfanyl-1H-benzimidazol-2-yl)carbamate
• CAS: 108579-67-5
• 化学式: C₁₂H₁₅N₃O₂S
• 分子量: 265.33
• InChiKey: SXJIZQPZESTWLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• OSTEOGENESIS PROMOTER AND USE THEREOF
  申请人：National University Corporation Nagoya University

  公开号：EP2749285A1

  公开（公告）日：2014-07-02

  The purpose of the present invention is to provide an osteogenesis promoter that can be administered locally and systemically and that is suitable for clinical application. Provided is an osteogenesis promoter that contains, as an active ingredient, at least one compound selected from the group consisting of phenazopyridine hydrochloride, riluzole hydrochloride, tranilast, rabeprazole, indoprofen, nabumetone, luteolin, leflunomide, lansoprazole, methiazole, thiabendazole, albendazole, tiaprofenic acid, balsalazide sodium salt, and cyclosporin A, or a pharmaceutically acceptable salt thereof. Preferably, rabeprazole or lansoprazole, which are proton pump inhibitors, is used as an active ingredient.

  本发明的目的是提供一种可局部和全身给药并适合临床应用的成骨促进剂。本发明提供了一种成骨促进剂，它含有至少一种选自由盐酸苯并吡啶、盐酸利鲁唑、氨非司特、雷贝拉唑组成的组的化合物作为活性成分、吲哚布洛芬、萘丁美酮、叶黄素、来氟米特、兰索拉唑、甲噻唑、噻苯达唑、阿苯达唑、噻丙芬酸、巴柳氮钠盐和环孢素 A 或其药学上可接受的盐。最好使用雷贝拉唑或兰索拉唑（质子泵抑制剂）作为活性成分。
• COMPOSITIONS AND METHODS FOR ENHANCING VIRUS EFFICACY
  申请人：Bell John

  公开号：US20120134963A1

  公开（公告）日：2012-05-31

  Provided are viral sensitizing compounds that enhance the efficacy of viruses by increasing spread of the virus in cells, increasing the titer of virus in cells, or increasing the cytotoxicity of virus to cells. Other uses, compositions and methods of using same are also provided.
• US20140343104A1
  申请人：——

  公开号：US20140343104A1

  公开（公告）日：2014-11-20
• US8940291B2
  申请人：——

  公开号：US8940291B2

  公开（公告）日：2015-01-27
• US9283254B2
  申请人：——

  公开号：US9283254B2

  公开（公告）日：2016-03-15