Zinc heptoate | 5261-20-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Zinc heptoate
• 英文别名: heptanoic acid;zinc
• CAS: 5261-20-1
• 化学式: C7H14O2Zn
• 分子量: 195.6
• InChiKey: HMUMQIBJFSEDDN-UHFFFAOYSA-N

物化性质

• 熔点：
  142.9 °C
• 密度：
  1.24 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.04
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• Storage stable topical pharmaceutical compositions containing zinc erythromycin and t-butanol
  申请人：THE PROCTER & GAMBLE COMPANY

  公开号：EP0109103A2

  公开（公告）日：1984-05-23

  A storage stable topical pharmaceutical composition containing zinc erythromycin, particularly useful in the topical treatment of acne vulgaris, is disclosed. This composition contains a solvent having a dielectric constant, measured at 25°C, of from about 5.5 to about 15, preferably from about 8 to about 12. such as t-butanol, to impart storage stability to the zinc erythromycin component. The composition may additonally contain particularly selected pharmaceutically-acceptable ni- trogencontaining stabilizer components, such as diisopropanolamine.

  本发明公开了一种含有红霉素锌的贮存稳定的外用药物组合物，尤其适用于寻常痤疮的外用治疗。该组合物含有一种溶剂，其介电常数（在 25°C 时测量）约为 5.5 至 15，优选约为 8 至 12，如叔丁醇，以赋予红霉素锌成分储存稳定性。该组合物还可添加特别选定的药学上可接受的含氮稳定剂成分，如二异丙醇胺。
• Polyvinyl chloride molding powder
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0151040A2

  公开（公告）日：1985-08-07

  The use of C5-C8 alkyl group fatty acid metal soap, particularly a mixture of barium and zinc such metal soaps, to satibilize polyvinyl chloride powder molding compositions against mold staining. The compositions preferably also include magnesium compound stabilizer to improve amine resistance when the molded product is to have polyurethane foam formed in situ thereon.

  使用 C5-C8 烷基脂肪酸金属皂，特别是钡和锌金属皂的混合物，使聚氯乙烯粉末模塑组合物达到饱和，防止模塑染色。这种组合物最好还包括镁化合物稳定剂，以便在模塑产品原位形成聚氨酯泡沫时，提高耐胺性。
• Vinyl chloride resin composition and matte-finished article
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0551684A1

  公开（公告）日：1993-07-21

  A vinyl chloride resin composition incorporating 0.002-0.02 mol of zinc carboxylate for 100 g of vinyl chloride resin and 0.3-5 mol of a compound having two or more alcoholic hydroxyl groups in one molecule per mol of said zinc carboxylate. This composition yields an article having a good matte-finished surface owing to minute corrugated irregularities formed on the surface.

  一种氯乙烯树脂组合物，每 100 克氯乙烯树脂含有 0.002-0.02 摩尔的羧酸锌，每摩尔羧酸锌含有 0.3-5 摩尔的在一个分子中含有两个或两个以上醇羟基的化合物。这种组合物生产出的产品表面具有良好的哑光效果，因为其表面形成了微小的波纹状不规则形。
• Zinc additives of enhanced performance capabilities
  申请人：ETHYL PETROLEUM ADDITIVES LIMITED

  公开号：EP0713907A2

  公开（公告）日：1996-05-29

  Novel zinc additives are provided which function as antioxidants and extreme pressure agents for lubricants and possess high thermal stability. In addition, they exhibit good filterability performance and good corrosion resistance. The zinc-containing additives are formed by admixing (i) at least one zinc dialkyldithiophosphate wherein each alkyl group contains 6 to 12 carbon atoms and is branched on its beta-carbon atom, and (ii) at least one zinc alkanoate wherein each alkanoate group is branched on its beta-carbon atom, in a ratio of 6.0 to 8.0 equivalents of (i) per equivalent of (ii).

  新型锌添加剂可用作润滑剂的抗氧化剂和极压剂，并具有较高的热稳定性。此外，它们还具有良好的过滤性和耐腐蚀性。这种含锌添加剂是由以下两种添加剂混合而成：(i) 至少一种二烷基二硫代磷酸锌，其中每个烷基含有 6 至 12 个碳原子，并且在其β-碳原子上有支链；(ii) 至少一种烷酸锌，其中每个烷酸基在其β-碳原子上有支链，混合比例为 6.0 至 8.0 个当量的(i)/当量的(ii)。
• PROCESS FOR PRODUCING SUSTAINED RELEASE PREPARATION
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1369130A1

  公开（公告）日：2003-12-10

  The present invention relates to a process for producing a sustained-release preparation comprising removing a solvent from an organic solvent solution containing a poorly water-soluble nonpeptidic physiologically active compound, a polyvalent metal compound and a biodegradable polymer, said physiologically active compound dissolved in an amount exceeding the solubility thereof in the organic solvent solution of biodegradable polymer in the absence of the polyvalent metal compound; a sustained-release preparation obtained by the process; a sustained-release solid pharmaceutical composition comprising a nonpeptidic physiologically active substance and a biodegradable polymer, wherein about 0.05% by weight or more, based on the weight of the composition, of a polyvalent metal is present on the surface of the composition; etc. In the sustained-release preparation, the poorly water-soluble nonpeptidic physiologically active compound is uniformly distributed and the sustained-release effect of the poorly water-soluble nonpeptidic physiologically active compound can be stably achieved. Moreover, a pharmaceutical composition comprising a nonpeptidic physiologically active substance wherein the initial burst release of the physiologically active substance is efficiently controlled, a process for producing the same, etc. are provided.

  本发明涉及一种生产缓释制剂的工艺，该工艺包括从含有水溶性差的非肽生理活性化合物、多价金属化合物和生物可降解聚合物的有机溶剂溶液中去除溶剂，所述生理活性化合物的溶解量超过其在没有多价金属化合物的情况下在生物可降解聚合物的有机溶剂溶液中的溶解度；由该工艺获得的一种缓释制剂； 一种缓释固体药物组合物，包括一种非肽类生理活性物质和一种生物可降解聚合物，其中约 0.05%(重量)或更多(基于组合物重量)的多价金属存在于组合物表面；等等。在该缓释制剂中，水溶性差的非肽生理活性化合物分布均匀，可稳定地实现水溶性差的非肽生理活性化合物的缓释效果。此外，还提供了一种包含非肽生理活性物质的药物组合物，其中生理活性物质的初始猝发释放得到了有效控制，还提供了生产该药物组合物的工艺等。