[6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-2-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate | 94079-81-9

• 物质功能分类: 生物化工 - 提取物
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: [6-[2-(3,4-dihydroxyphenyl)ethoxy]-5-hydroxy-4-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxy-2-[(3,4,5-trihydroxy-6-methyloxan-2-yl)oxymethyl]oxan-3-yl] (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate
• CAS: 94079-81-9
• 化学式: C₃₅H₄₆O₁₉
• 分子量: 770.7
• InChiKey: YMWRMAOPKNYHMZ-VMPITWQZSA-N

物化性质

• 沸点：
  1023.2±65.0 °C(Predicted)
• 密度：
  1.62
• 溶解度：
  DMSO : 100 mg/mL (129.75 mM; 需要超声) 乙醇 : 50 mg/mL (64.87 mM; 需要超声)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.6
• 重原子数：
  54
• 可旋转键数：
  13
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  304
• 氢给体数：
  11
• 氢受体数：
  19

安全信息

• WGK Germany：
  3

制备方法与用途

生物活性

Poliumoside 对晚期糖基化终产物（AGE）的形成有显著抑制作用，IC50值为19.69 μM。在大鼠晶状体醛糖还原酶测定试验中，发现 Poliumoside 对 rat lens aldose reductase (RLAR) 表现出抑制作用，IC50值为8.47 μM。

靶点

Target	Value
RLAR	8.47 μM

体外研究

Poliumoside 抑制 AGE 形成和 RLAR，IC50 值分别为19.69 μM 和 8.47 μM。此外，Poliumoside（5-30 μM；3 h）抑制 AAPH 引起的体外大鼠红细胞溶血现象。同时，在 LPS 刺激的 RAW 264.7 细胞中，Poliumoside（12.5-100 μM；预处理2 h）也抑制 TNF-α 和 IL-6 的释放。

体内研究

Poliumoside 抑制乳酸鱼胚胎的血管扩张。

化学性质

类白色结晶粉末，溶于水，来源于广东紫珠。

用途

金石蚕苷具有抗菌、消炎和抗病毒作用。主要用于含量测定/鉴定/药理实验等。其药理药效为散瘀止血、消肿止痛；叶可用于治疗吐血、咯血、衄血、便血，外用可治疗外伤出血。

文献信息

• Methods and compositions for administering a specific wavelength phototherapy
  申请人：Follea International

  公开号：US10111821B2

  公开（公告）日：2018-10-30

  Methods are disclosed for administering electromagnetic radiation (EMR), which may include filtering EMR from part of the EMR spectrum while allowing passage of EMR at a desired wavelength range. Uses may include the treatment of such conditions as psoriasis, vitiligo, pruritus, acne, vitamin-D deficiency and atopic dermatitis. Topical creams, sprays, or other compositions may be used, with or without dosimeters, or in conjunction with an application, which calculates local UV exposure and other factors relating to dosage.

  所公开的方法用于管理电磁辐射（EMR），其中可包括过滤电磁辐射光谱的一部分，同时允许所需波长范围的电磁辐射通过。其用途可包括治疗牛皮癣、白癜风、瘙痒症、痤疮、维生素 D 缺乏症和特应性皮炎等疾病。可以使用外用药膏、喷雾剂或其他组合物，可以使用或不使用剂量计，也可以与计算局部紫外线照射量和与剂量有关的其他因素的应用程序结合使用。
• Methods And Compositions For Administering A Specific Wavelength Phototherapy
  申请人：Goren Andy Ofer

  公开号：US20130115180A1

  公开（公告）日：2013-05-09

  Methods and compositions are disclosed for administering electromagnetic radiation (EMR), for therapeutic or cosmetic purposes, or for purposes of curing a polymeric material.
• METHODS AND COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY
  申请人：Applied Biology, Inc.

  公开号：US20140121732A1

  公开（公告）日：2014-05-01

  Methods are disclosed for administering electromagnetic radiation (EMR), which may include filtering EMR from part of the EMR spectrum while allowing passage of EMR at a desired wavelength range. Uses may include the treatment of such conditions as psoriasis, vitiligo, pruritus, acne, vitamin-D deficiency and atopic dermatitis. Topical creams, sprays, or other compositions may be used, with or without dosimeters, or in conjunction with an application, which calculates local UV exposure and other factors relating to dosage.
• [EN] METHODS AND COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY<br/>[FR] PROCÉDÉS ET COMPOSITIONS POUR L'ADMINISTRATION D'UNE PHOTOTHÉRAPIE À LONGUEUR D'ONDE SPÉCIFIQUE
  申请人：FOLLEA INTERNAT LTD

  公开号：WO2013067543A1

  公开（公告）日：2013-05-10

  Methods and compositions are disclosed for administering electromagnetic radiation (EMR), for therapeutic or cosmetic purposes, or for purposes of curing a polymeric material.
• [EN] COMPOSITIONS FOR ADMINISTERING A SPECIFIC WAVELENGTH PHOTOTHERAPY<br/>[FR] COMPOSITIONS POUR ADMINISTRATION DE PHOTOTHÉRAPIE DE LONGUEUR D'ONDE SPÉCIFIQUE
  申请人：GLOBAL LIFE SCIENCE PARTNERS LTD

  公开号：WO2014070266A1

  公开（公告）日：2014-05-08

  Methods are disclosed for administering electromagnetic radiation (EMR), which may include filtering EMR from part of the EMR spectrum while allowing passage of EMR at a desired wavelength. A fluorescent component may be included, which absorbs EMR at one wavelength and emits EMR at the desired wavelength. Uses may include the treatment of acne. Pruritus may also be treated by allowing the passage to the skin of a particular UV wavelength from sunlight, which has an immunosuppressive effect, while protecting the skin from other harmful UV radiation.