urs-12-ene | 464-97-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: urs-12-ene
• 英文别名: Urs-12-en；Ursen-(12)；α-Amyren；(1S,2R,4Ar,6aR,6aS,6bR,8aS,12aS,14bR)-1,2,4a,6a,6b,9,9,12a-octamethyl-2,3,4,5,6,6a,7,8,8a,10,11,12,13,14b-tetradecahydro-1H-picene
• CAS: 464-97-1
• 化学式: C₃₀H₅₀
• 分子量: 410.727
• InChiKey: DGXIUFDVYPIXCI-XRBCGWODSA-N

物化性质

• 熔点：
  124 °C(Solv: ethyl ether (60-29-7); methanol (67-56-1))
• 沸点：
  464.1±12.0 °C(Predicted)
• 密度：
  0.96±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  10.5
• 重原子数：
  30
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  urs-12-ene 在 双氧水 作用下， 生成 13α-ursan-12-one
  参考文献：
  名称：

  210.三萜烯树脂醇和相关酸。第XX部分。α-amyrin转化为异-α-amrananone（12-ketoursane）

  摘要：

  DOI：

  10.1039/jr9510000935
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 sodium ethanolate 作用下， 生成 urs-12-ene
  参考文献：
  名称：

  210.三萜烯树脂醇和相关酸。第XX部分。α-amyrin转化为异-α-amrananone（12-ketoursane）

  摘要：

  DOI：

  10.1039/jr9510000935

文献信息

• Terpenoids. LVII.¹ Mass Spectral and Nuclear Magnetic Resonance Studies of Pentacyclic Triterpene Hydrocarbons²
  作者：Jerry Karliner、Carl Djerassi

  DOI：10.1021/jo01344a063

  日期：1966.6
• Winterstein; Stein, Justus Liebigs Annalen der Chemie, 1933, vol. 502, p. 223,234
  作者：Winterstein、Stein

  DOI：——

  日期：——
• Long-term glycemic control measurements in diabetic patients receiving hemodialysis
  作者：Melanie S. Joy、William T. Cefalu、Susan L. Hogan、Patrick H. Nachman

  DOI：10.1053/ajkd.2002.30549

  日期：2002.2

  Cardiovascular morbidity is increased in patients with diabetes mellitus and there is a great prevalence of diabetes and cardiovascular disease among patients with end-stage renal disease (ESRD). Control of glycemia can decrease cardiovascular and end-organ damage. Because the validity of glycemic control tests have not been rigorously studied in patients with ESRD, we evaluated the value of various measures in these patients. The overall clinical goal was to investigate whether hemoglobin A(1)C (A(1)C) accurately reflects actual glycemic control as compared with other measures in light of the importance of attaining appropriately controlled blood glucose (BG). The commonly used tests of total glycated hemoglobin (GHb) and A(1)C may be unreliable in patients with ESRD because of the presence of anemia, shortened red blood cell (RBC) survival, and assay interferences from uremia. The primary aim of this study was to assess the relationship of capillary BG measurements to A(1)C, GHb, total glycated plasma proteins (GPP), and fructosamine (Fr) in diabetic patients receiving hemodialysis. Twenty-three patients were instructed to obtain BG evaluations twice daily for 7 days by using the Elite glucometer (Bayer Corporation, Elkhart, IN). These determinations included 6 fasting, 6 preprandial, and 3 separate 2-hour postprandial levels. Blood was obtained on day 7 for measurement of A(1)C, GHb, GPP, and Fr. A(1)C was analyzed by an immunoassay, GPP and GHb were assayed by affinity high-performance liquid chromatography (HPLC), and Fr by automated nitroblue colorimetric assay. Scatter plots were generated by plotting the average BG versus A(1)C, GHb, GPP, or Fr. Linear regression was performed for each plot showing the following relationships: A(1)C = 0.0174 (BG) + 4.76 (r = 0.58; P < 0.05): GHb = 0.0371 (BG) + 3.57 (r = 0.584; P < 0.05): GPP = 0.0083 (BG) + 26.13 (r = 0.065; P = 0.77): Fr = 0.6865 (BG) + 250 (r = 0.345; P = 0.11). Despite anemia and shortened RBC lifespan in patients with ESRD, A(1)C in the range of 6% to 7% estimates glycemic control similarly to patients without severe renal impairment. A(1)C values above 7.5% may overestimate hyperglycemia in patients with ESRD. Thus, diabetic patients receiving hemodialysis may have long-term BG that are more properly controlled than previously determined, reducing their risks of the macro- and microvascular complications of diabetes mellitus. (C) 2002 by the National Kidney Foundation, Inc.
• 99. The chemistry of the triterpenes. Part VIII. The α- and β-amyrenes
  作者：G. S. Davy、T. G. Halsall、E. R. H. Jones

  DOI：10.1039/jr9510000458

  日期：——
• 447. Triterpenoids. Part XIII. Phyllanthol, the first hexacarbocyclic triterpenoid
  作者：D. H. R. Barton、P. de Mayo

  DOI：10.1039/jr9530002178

  日期：——