(20R,23E)-eupha-8,23-diene-3b,25-diol | 227008-51-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: (20R,23E)-eupha-8,23-diene-3b,25-diol
• 英文别名: (3S,5R,10S,13S,14S,17S)-17-[(E,2R)-6-hydroxy-6-methylhept-4-en-2-yl]-4,4,10,13,14-pentamethyl-2,3,5,6,7,11,12,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 227008-51-7
• 化学式: C₃₀H₅₀O₂
• 分子量: 442.726
• InChiKey: YLPXHUMIKSOPEX-PVLXGJMFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.1
• 重原子数：
  32
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  40.5
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (20R,23E)-eupha-8,23-diene-3b,25-diol 在 pyridinium chlorochromate 作用下， 以 二氯甲烷 为溶剂， 以2 mg的产率得到lanosterol
  参考文献：
  名称：

  (20R,23E)-Eupha-8,23-diene-3β,25-diol from Tripetalum cymosum

  摘要：

  A new euphane triterpenoid, (20R,23E)-eupha-8,23-diene-3 beta,25-diol, was isolated from the leaves of Tripetalum cymosum and its structure was determined by spectral analysis and chemical correlation with euphol. Caryophyllene oxide, friedelin, euphol and putranjivic acid were also obtained from the leaves whilst the bark afforded euphol, glutin-5-en-3 beta-ol, butyrospermol and dammara-20,24-dien-3 beta-ol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(98)00565-2
• 作为产物：
  描述：

  大戟二烯醇 在 氧气 、 亚甲兰 作用下， 以 乙醇 为溶剂， 以31 mg的产率得到(20R,23E)-eupha-8,23-diene-3b,25-diol
  参考文献：
  名称：

  (20R,23E)-Eupha-8,23-diene-3β,25-diol from Tripetalum cymosum

  摘要：

  A new euphane triterpenoid, (20R,23E)-eupha-8,23-diene-3 beta,25-diol, was isolated from the leaves of Tripetalum cymosum and its structure was determined by spectral analysis and chemical correlation with euphol. Caryophyllene oxide, friedelin, euphol and putranjivic acid were also obtained from the leaves whilst the bark afforded euphol, glutin-5-en-3 beta-ol, butyrospermol and dammara-20,24-dien-3 beta-ol. (C) 1999 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0031-9422(98)00565-2

文献信息

• INGENANE-TYPE DITERPENE COMPOUND, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING VIRAL INFECTIOUS DISEASES CONTAINING SAME
  申请人：KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY

  公开号：US20140371311A1

  公开（公告）日：2014-12-18

  The present invention relates to an injenane-type diterpene compound derived from Euphorbia kansui Liou, and a pharmaceutical composition for treating or preventing viral infectious diseases, a health functional food for preventing or ameliorating viral infectious diseases and a composition for enhancing the production of interferon-gamma, which comprise the injenane-type diterpene compound. Furthermore, the present invention relates to a method for preventing or treating viral infectious diseases including administering the composition to a subject having a viral infectious disease occurrence or a risk thereof with a therapeutically effective dose.

  本发明涉及一种源自宽叶大戟的龙胆烯型二萜化合物，以及用于治疗或预防病毒性感染疾病的制药组合物，用于预防或改善病毒性感染疾病的健康功能食品和用于增强γ-干扰素产生的组合物，其中包括龙胆烯型二萜化合物。此外，本发明还涉及一种预防或治疗病毒性感染疾病的方法，包括向患有病毒性感染疾病或存在风险的受试者施用治疗有效剂量的该组合物。
• INGENANE-TYPE DITERPENE COMPOUND, AND PHARMACEUTICAL COMPOSITION FOR TREATING OR PREVENTING VIRAL INFECTIOUS DISEASES
  申请人：Korea Research Institute of Bioscience and Biotechnology

  公开号：EP2769973B1

  公开（公告）日：2018-09-12
• US9481630B2
  申请人：——

  公开号：US9481630B2

  公开（公告）日：2016-11-01
• (20R,23E)-Eupha-8,23-diene-3β,25-diol from Tripetalum cymosum
  作者：Yuan-Wah Leong、Leslie J Harrison

  DOI：10.1016/s0031-9422(98)00565-2

  日期：1999.3

  A new euphane triterpenoid, (20R,23E)-eupha-8,23-diene-3 beta,25-diol, was isolated from the leaves of Tripetalum cymosum and its structure was determined by spectral analysis and chemical correlation with euphol. Caryophyllene oxide, friedelin, euphol and putranjivic acid were also obtained from the leaves whilst the bark afforded euphol, glutin-5-en-3 beta-ol, butyrospermol and dammara-20,24-dien-3 beta-ol. (C) 1999 Elsevier Science Ltd. All rights reserved.