2-<2-(methoxymethoxy)ethyl>-6,6-dimethylbicyclo<3.1.1>hept-2-ene | 77661-66-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-<2-(methoxymethoxy)ethyl>-6,6-dimethylbicyclo<3.1.1>hept-2-ene
• 英文别名: 2-[2-(Methoxymethoxy)ethyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene；2-[2-(methoxymethoxy)ethyl]-6,6-dimethylbicyclo[3.1.1]hept-2-ene
• CAS: 77661-66-6
• 化学式: C₁₃H₂₂O₂
• 分子量: 210.316
• InChiKey: IDQBDQRFSMMHFL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-<2-(methoxymethoxy)ethyl>-6,6-dimethylbicyclo<3.1.1>hept-2-ene 在 氯化锆(IV) 作用下， 以 异丙醇 为溶剂， 反应 4.0h， 以93%的产率得到6,6-二甲基二环[3.1.1]庚-2-烯-2-乙醇
  参考文献：
  名称：

  An efficient protocol for the preparation of MOM ethers and their deprotection using zirconium(IV) chloride

  摘要：

  An efficient protocol for the preparation of MOM ethers from alcohols and formaldehyde dimethyl acetal (DMFA) using ZrCl4 (10 mol%) at room temperature under solvent free conditions has been developed. Similarly, the same Lewis acid, ZrCl4 (50 mol%), in isopropanol at reflux was utilised for the deprotection of MOM ethers. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.10.091
• 作为产物：
  描述：

  二甲醇缩甲醛 、 6,6-二甲基二环[3.1.1]庚-2-烯-2-乙醇 在 氯化锆(IV) 作用下， 反应 6.5h， 以97%的产率得到2-<2-(methoxymethoxy)ethyl>-6,6-dimethylbicyclo<3.1.1>hept-2-ene
  参考文献：
  名称：

  An efficient protocol for the preparation of MOM ethers and their deprotection using zirconium(IV) chloride

  摘要：

  An efficient protocol for the preparation of MOM ethers from alcohols and formaldehyde dimethyl acetal (DMFA) using ZrCl4 (10 mol%) at room temperature under solvent free conditions has been developed. Similarly, the same Lewis acid, ZrCl4 (50 mol%), in isopropanol at reflux was utilised for the deprotection of MOM ethers. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2004.10.091

文献信息

• Preparation of formaldehyde and acetaldehyde acetals
  作者：Bhalchandra C. Barot、Harold W. Pinnick

  DOI：10.1021/jo00327a032

  日期：1981.7
• An efficient protocol for the preparation of MOM ethers and their deprotection using zirconium(IV) chloride
  作者：G.V.M. Sharma、K. Laxma Reddy、P. Sree Lakshmi、Palakodety Radha Krishna

  DOI：10.1016/j.tetlet.2004.10.091

  日期：2004.12

  An efficient protocol for the preparation of MOM ethers from alcohols and formaldehyde dimethyl acetal (DMFA) using ZrCl4 (10 mol%) at room temperature under solvent free conditions has been developed. Similarly, the same Lewis acid, ZrCl4 (50 mol%), in isopropanol at reflux was utilised for the deprotection of MOM ethers. (C) 2004 Elsevier Ltd. All rights reserved.