2,4-diisopropylquinoline | 22493-98-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2,4-diisopropylquinoline
• 英文别名: 2,4-Di(propan-2-yl)quinoline
• CAS: 22493-98-7
• 化学式: C₁₅H₁₉N
• 分子量: 213.323
• InChiKey: RELINQGUHIKGEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  喹啉 、 异丁酸 在 2-吡啶甲酸 、 ferrous(II) sulfate heptahydrate 、 sodium bromate 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 24.0h， 以64%的产率得到2,4-diisopropylquinoline
  参考文献：
  名称：

  Ligand-Accelerated Iron Photocatalysis Enabling Decarboxylative Alkylation of Heteroarenes

  摘要：

  A mild, practical protocol for the decarboxylative alkylation of heteroarenes has been accomplished via iron photocatalysis. A diverse range of carboxylic acids readily undergo oxidative decarboxylation and then couple with a broad array of heteroarenes in this transformation. The photoexcited state lifetimes of iron complexes are typically much shorter than those of iridium and ruthenium complexes. Here we describe our effort on iron photocatalysis by utilizing the intramolecular charge transfer pathway of iron-carboxylate complexes.

  DOI：

  10.1021/acs.orglett.9b01439

文献信息

• A Novel, Simple and Cheap Source of Alkyl Radicals from Alcohols, Useful for Heteroaromatic Substitution
  作者：Fausta Coppa、Francesca Fontana、Edoardo Lazzarini、Francesco Minisci、Giuseppe Pianese、Lihua Zhao

  DOI：10.1246/cl.1992.1295

  日期：1992.7

  Alkyl radicals were easily produced from secondary or tertiary alcohols in a cheap and simple way by silver-catalyzed decarboxylation of oxalic acid monoesters by S2O8=. They were utilized for the alkylation of heteroaromatic bases in a two-phase system, with high yields and selectivity.

  通过 S2O8= 银催化的草酸单酯脱羧反应，可以很容易地从仲醇或叔醇以廉价和简单的方式制备烷基自由基。它们被用于两相系统中杂芳烃碱的烷基化，具有高产率和选择性。
• Dioxygen-Mediated Decarbonylative CH Alkylation of Heteroaromatic Bases with Aldehydes
  作者：Subhasis Paul、Joyram Guin

  DOI：10.1002/chem.201503809

  日期：2015.12.1

  An operationally simple and economical method for the direct alkylation of heteroaromatic bases employing readily available aldehydes as alkyl radical precursors and molecular oxygen as a reagent is presented. This simple transformation demonstrates a broad substrate scope with respect to aldehydes and nitrogen heterocycles, enabling the introduction of several medicinally important yet challenging

  提出了一种操作简单且经济的方法，用于将杂芳族碱直接烷基化，该方法使用容易获得的醛作为烷基前体，并使用分子氧作为试剂。这种简单的转化展示了针对醛和氮杂环的广泛底物范围，从而能够将几种具有医学重要性但极具挑战性的烷基部分（例如乙基，异丙基，叔丁基和环己基）引入到不同类别的杂环碱中，优异的产量。
• A new general method of homolytic alkylation of protonated heteroaromatic bases by carboxylic acids and iodosobenzene diacetate
  作者：Francesco Minisci、Elena Vismara、Francesca Fontana、Maria Claudia Nogueira Barbosa

  DOI：10.1016/s0040-4039(01)80747-4

  日期：1989.1

  A new general, simple and mild procedure is reported in this communication, based on the photochemically induced decarboxylation of carboxylic acids by iodosobenzene diacetate to obtain the substitution of bases by nucleophilic alkyl radicals.

  在本通讯中报道了一种新的通用，简单和温和的程序，该程序基于碘代苯二乙酸酯通过光化学诱导的羧酸脱羧反应，从而获得亲核性烷基取代碱基。
• AMINO-ETHYL-AMINO-ARYL (AEAA) COMPOUNDS AND THEIR USE
  申请人：Raynham Tony Michael

  公开号：US20090247519A1

  公开（公告）日：2009-10-01

  The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain amino-ethyl-amino-aryl (AEAA) compounds which, inter alia, inhibit protein kinase D (PKD) (e.g., PKD1, PKD2, PKD3). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit PKD, and in the treatment of diseases and conditions that are mediated by PKD, that are ameliorated by the inhibition of PKD, etc., including proliferative conditions such as cancer, etc.

  本发明一般涉及治疗化合物领域，更具体地涉及某些氨基乙基氨基芳基（AEAA）化合物，该化合物在抑制蛋白激酶D（PKD）（例如，PKD1、PKD2、PKD3）方面起作用。本发明还涉及包含这些化合物的药物组合物，以及在体外和体内使用这些化合物和组合物来抑制PKD，并用于治疗由PKD介导的疾病和症状，通过抑制PKD而改善的疾病和症状等，包括增殖性疾病如癌症等。
• A novel convenient and selective alkoxycarbonylation of heteroaromatic bases by oxalic acid monoesters
  作者：Fausta Coppa、Francesca Fontana、Edoardo Lazzarini、Francesco Minisci、Giuseppe Pianese、Lihua Zhao

  DOI：10.1016/s0040-4039(00)79599-2

  日期：1992.5

  ethoxycarbonyl radicals were easily produced by silver-catalyzed decarboxylation of methyl and ethyl esters of oxalic acid by S2O8=. They were utilized for the alkoxycarbonylation of heteroaromatic bases with high yield and selectivity in a two-phase system, suitable for practical applications.

  甲氧基和乙氧基羰基很容易通过S 2 O 8 =通过银催化草酸的甲酯和乙酯的羧化反应制得。它们被用于两相体系中的高收率和选择性的杂芳族碱的烷氧基羰基化反应，适合实际应用。