1-(4-(2,5-difluorobenzyloxy)phenyl)ethanone | 187532-84-9

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(4-(2,5-difluorobenzyloxy)phenyl)ethanone
• 英文别名: 4-(2,5-difluorobenzyloxy)acetophenone；1-[4-[(2,5-Difluorophenyl)methoxy]phenyl]ethanone
• CAS: 187532-84-9
• 化学式: C₁₅H₁₂F₂O₂
• 分子量: 262.256
• InChiKey: WYYGXDBYHAXTOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-(4-(2,5-difluorobenzyloxy)phenyl)ethanone 在 甲醇 、 potassium carbonate 、 对甲苯磺酸 、 间氯过氧苯甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 0.35h， 生成 4-(2,5-difluorobenzyloxy)phenol
  参考文献：
  名称：

  High-speed microwave assisted synthesis of SEA0400—a selective inhibitor of the Na+/Ca2+ exchanger

  摘要：

  An efficient and rapid five-step synthesis of SEA0400, a selective Na+/Ca2+ exchanger (NCX) inhibitor, using controlled microwave heating is reported. In addition, a novel three-step route omitting the key Baeyer Villiger oxidation/hydrolysis sequence has been developed. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2012.04.120
• 作为产物：
  描述：

  2,5-二氟苄溴 、 对羟基苯乙酮 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.67h， 以71%的产率得到1-(4-(2,5-difluorobenzyloxy)phenyl)ethanone
  参考文献：
  名称：

  Novel aryloxy azolyl chalcones with potent activity against Mycobacterium tuberculosis H37Rv

  摘要：

  A series of twenty seven novel aryloxy azolyl chalcones were synthesized and evaluated in vitro for the growth inhibition of Mycobacterium tuberculosis H37Rv. Ten compounds from this series exhibited good activity with MIC in the range of 3.12-0.78 mu g/mL and six of them were found non-toxic against VERO cells and MBMDMos (mouse bone-marrow derived macrophages), were further evaluated ex-vivo for their potential to kill intracellular bacilli. Two compounds 4 and 19 showed 99% and 71% killing respectively, of intracellular bacilli in MBMDMos infection model. Further, compound 19, an imidazolyl chalcone with a 2,4-difluorobenzyloxy moiety also exhibited moderate in vivo activity in mice against virulent M. tuberculosis, thus providing a new structural lead towards TB drug development. (C) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.06.037

文献信息

• Compounds for the treatment of metabolic disorders
  申请人：——

  公开号：US20030149107A1

  公开（公告）日：2003-08-07

  Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

  适用于治疗各种代谢性疾病的化合物，如胰岛素抵抗综合征、糖尿病、高脂血症、脂肪肝病、虚弱、肥胖、动脉粥样硬化和动脉硬化的化合物已被披露。
• Compound for the treatment of metabolic disorders
  申请人：Sharma Shalini

  公开号：US20050090555A1

  公开（公告）日：2005-04-28

  Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

  本发明涉及一种用于治疗各种代谢障碍的化合物，如胰岛素抵抗综合症、糖尿病、高脂血症、脂肪肝病、消瘦、肥胖症、动脉粥样硬化和动脉硬化等。
• COMPOUNDS FOR THE TREATMENT OF METABOLIC DISORDERS
  申请人：Sharma Shalini

  公开号：US20070105958A1

  公开（公告）日：2007-05-10

  Compounds useful for the treatment of various metabolic disorders, such as insulin resistance syndrome, diabetes, hyperlipidemia, fatty liver disease, cachexia, obesity, atherosclerosis and arteriosclerosis, are disclosed.

  本发明揭示了一些化合物，用于治疗各种代谢性疾病，如胰岛素抵抗综合征、糖尿病、高脂血症、脂肪肝病、消瘦、肥胖症、动脉粥样硬化和动脉硬化等。
• US6916848B2
  申请人：——

  公开号：US6916848B2

  公开（公告）日：2005-07-12
• US6858602B2
  申请人：——

  公开号：US6858602B2

  公开（公告）日：2005-02-22