(3aR,5r,6aS)-2,2-dimethyl-5-((E)-prop-1-en-1-yl)tetrahydro-4H-cyclopenta[d][1,3]dioxole | 128173-46-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (3aR,5r,6aS)-2,2-dimethyl-5-((E)-prop-1-en-1-yl)tetrahydro-4H-cyclopenta[d][1,3]dioxole
• CAS: 128173-46-6
• 化学式: C₁₁H₁₈O₂
• 分子量: 182.263
• InChiKey: YAYFTWYTSDONIB-OISYINEBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.49
• 重原子数：
  13.0
• 可旋转键数：
  1.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  18.46
• 氢给体数：
  0.0
• 氢受体数：
  2.0

反应信息

• 作为反应物：
  描述：

  (3aR,5r,6aS)-2,2-dimethyl-5-((E)-prop-1-en-1-yl)tetrahydro-4H-cyclopenta[d][1,3]dioxole 在 盐酸 、 10% Pd(OH)2 on carbon 、 氢气 作用下， 以 四氢呋喃 、 甲醇 、 水 为溶剂， 反应 3.0h， 生成 4-propylcyclopentane-1,2-diol
  参考文献：
  名称：

  Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives

  摘要：

  Innate immunity is the front line of self-defense against infectious microorganisms. In mammals, innate immunity interacts with adaptive immunity and plays a key role in regulating the immune response. Therefore, innate immunity is a good pharmaceutical target for the development of immune regulators. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a cyclopentanediol-type compound 1 as an immunosuppressor. In this study, we synthesized and evaluated 1 and its derivatives. Several methylamide- or phenylamide-containing derivatives showed effects that were 20-25 times more potent than those of 1. (c) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.049
• 作为产物：
  描述：

  3-环戊烯-1,1-二甲酸二乙酯 在 N-氯代丁二酰亚胺 、 四氧化锇 、 lithium aluminium tetrahydride 、 2,2,6,6-四甲基哌啶氧化物 、 三氧化硫吡啶 、 sodium hydride 、 二异丁基氢化铝 、 碳酸氢钠 、 potassium carbonate 、 N-甲基吗啉氧化物 、 lithium chloride 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 二甲基亚砜 、 丙酮 、 甲苯 、 乙腈 、 mineral oil 为溶剂， 反应 40.5h， 生成 (3aR,5r,6aS)-2,2-dimethyl-5-((E)-prop-1-en-1-yl)tetrahydro-4H-cyclopenta[d][1,3]dioxole
  参考文献：
  名称：

  Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives

  摘要：

  Innate immunity is the front line of self-defense against infectious microorganisms. In mammals, innate immunity interacts with adaptive immunity and plays a key role in regulating the immune response. Therefore, innate immunity is a good pharmaceutical target for the development of immune regulators. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a cyclopentanediol-type compound 1 as an immunosuppressor. In this study, we synthesized and evaluated 1 and its derivatives. Several methylamide- or phenylamide-containing derivatives showed effects that were 20-25 times more potent than those of 1. (c) 2011 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2011.01.049

文献信息

• GHISALBERTI, E. L.;NARBEY, M. J.;ROWLAND, C. Y., J. NATUR. PROD., 53,(1990) N, C. 520-522
  作者：GHISALBERTI, E. L.、NARBEY, M. J.、ROWLAND, C. Y.

  DOI：——

  日期：——
• Synthesis and innate immunosuppressive effect of 1,2-cyclopentanediol derivatives
  作者：Haruhisa Kikuchi、Kaori Okazaki、Mizuki Sekiya、Yasuyuki Uryu、Kazunori Ueda、Yasuhiro Katou、Shoichiro Kurata、Yoshiteru Oshima

  DOI：10.1016/j.ejmech.2011.01.049

  日期：2011.4

  Innate immunity is the front line of self-defense against infectious microorganisms. In mammals, innate immunity interacts with adaptive immunity and plays a key role in regulating the immune response. Therefore, innate immunity is a good pharmaceutical target for the development of immune regulators. After searching for natural substances that regulate innate immunity using an ex vivo Drosophila culture system, we identified a cyclopentanediol-type compound 1 as an immunosuppressor. In this study, we synthesized and evaluated 1 and its derivatives. Several methylamide- or phenylamide-containing derivatives showed effects that were 20-25 times more potent than those of 1. (c) 2011 Elsevier Masson SAS. All rights reserved.