联苯-4-羧酸甲酯 | 720-75-2

• 物质功能分类: 化学试剂 - 有机试剂 - 酯类
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 联苯-4-羧酸甲酯
• 中文别名: 联苯-4-甲酸甲酯；4-甲基联苯-2-甲酸甲酯；4-联苯羧酸甲酯
• 英文名称: methyl 4-phenylbenzoate
• 英文别名: methyl [1,1'-biphenyl]-4-carboxylate；methyl [1,1′-biphenyl]-4-carboxylate；methyl biphenyl-4-carboxylate；methyl 4-biphenylcarboxylate；4-(methoxycarbonyl)biphenyl
• CAS: 720-75-2
• 化学式: C₁₄H₁₂O₂
• mdl: MFCD00017200
• 分子量: 212.248
• InChiKey: GATUGNVDXMYTJX-UHFFFAOYSA-N

物化性质

• 熔点：
  118°C
• 沸点：
  110-130 °C(Press: 3 Torr)
• 密度：
  1.101±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  在常温常压下保持稳定，应避免与氧化物接触。

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.071
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• TSCA：
  Yes
• 危险等级：
  IRRITANT
• WGK Germany：
  3
• 海关编码：
  2916399090
• 安全说明：
  S22,S24/25
• 储存条件：
  请将容器密封后，存放在干燥、阴凉处。

SDS

Material Safety Data Sheet

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Section 1. Identification of the substance
Product Name: Methyl 4-biphenylcarboxylate
Synonyms:

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Section 2. Hazards identification
Harmful by inhalation, in contact with skin, and if swallowed.

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Section 3. Composition/information on ingredients.
Ingredient name: Methyl 4-biphenylcarboxylate
CAS number: 720-75-2

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Section 4. First aid measures
Skin contact: Immediately wash skin with copious amounts of water for at least 15 minutes while removing
contaminated clothing and shoes. If irritation persists, seek medical attention.
Eye contact: Immediately wash skin with copious amounts of water for at least 15 minutes. Assure adequate
flushing of the eyes by separating the eyelids with fingers. If irritation persists, seek medical
attention.
Inhalation: Remove to fresh air. In severe cases or if symptoms persist, seek medical attention.
Ingestion: Wash out mouth with copious amounts of water for at least 15 minutes. Seek medical attention.

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Section 5. Fire fighting measures
In the event of a fire involving this material, alone or in combination with other materials, use dry
powder or carbon dioxide extinguishers. Protective clothing and self-contained breathing apparatus
should be worn.

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Section 6. Accidental release measures
Personal precautions: Wear suitable personal protective equipment which performs satisfactorily and meets local/state/national
standards.
Respiratory precaution: Wear approved mask/respirator
Hand precaution: Wear suitable gloves/gauntlets
Skin protection: Wear suitable protective clothing
Eye protection: Wear suitable eye protection
Methods for cleaning up: Mix with sand or similar inert absorbent material, sweep up and keep in a tightly closed container
for disposal. See section 12.
Environmental precautions: Do not allow material to enter drains or water courses.

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Section 7. Handling and storage
Handling: This product should be handled only by, or under the close supervision of, those properly qualified
in the handling and use of potentially hazardous chemicals, who should take into account the fire,
health and chemical hazard data given on this sheet.
Store in closed vessels.
Storage:

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Section 8. Exposure Controls / Personal protection
Engineering Controls: Use only in a chemical fume hood.
Personal protective equipment: Wear laboratory clothing, chemical-resistant gloves and safety goggles.
General hydiene measures: Wash thoroughly after handling. Wash contaminated clothing before reuse.

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Section 9. Physical and chemical properties
Appearance: Not specified
Boiling point: No data
No data
Melting point:
Flash point: No data
Density: No data
Molecular formula: C14H12O2
Molecular weight: 212.2

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Section 10. Stability and reactivity
Conditions to avoid: Heat, flames and sparks.
Materials to avoid: Oxidizing agents.
Possible hazardous combustion products: Carbon monoxide.

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Section 11. Toxicological information
No data.

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Section 12. Ecological information
No data.

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Section 13. Disposal consideration
Arrange disposal as special waste, by licensed disposal company, in consultation with local waste
disposal authority, in accordance with national and regional regulations.

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Section 14. Transportation information
Non-harzardous for air and ground transportation.

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Section 15. Regulatory information
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section
302, or have known CAS numbers that exceed the threshold reporting levels established by SARA
Title III, Section 313.

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SECTION 16 - ADDITIONAL INFORMATION
N/A

制备方法与用途

联苯-4-甲酸甲酯被用作有机合成中间体和医药中间体，主要应用于实验室研发和化工生产的各个环节。

反应信息

• 作为反应物：
  描述：

  联苯-4-羧酸甲酯 在 lithium hydroxide 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 反应 4.0h， 生成 4-苯基苯甲酸
  参考文献：
  名称：

  Diflunisal类似物稳定运甲状腺素蛋白的天然状态。有效抑制淀粉样蛋白生成。

  摘要：

  合成了FDA批准的非甾体抗炎药diflunisal的类似物，并将其评估为转甲状腺素蛋白（TTR）聚集（包括淀粉样蛋白原纤维形成）的抑制剂。对于26种化合物观察到高抑制活性。其中，八种在人血浆中对TTR表现出优异的结合选择性（结合化学计量比> 0.50，每个TTR四聚体理论上最多结合有2.0种抑制剂）。生物物理研究表明，这八种抑制剂可在168小时的时间内显着减慢四聚体的解离（淀粉样蛋白生成的速率决定步骤）。这似乎是通过基态稳定化来实现的，这提高了四聚体解离的动力学势垒。这八种抑制剂对WT TTR的动力学稳定作用进一步得到证实，淀粉样蛋白原纤维形成的速率随抑制剂浓度（pH 4.4）的增加而降低。TTR.18（2）和TTR.20（2）配合物的X射线共晶体结构揭示了18和20在TTR结合位点以相反的方向结合。将氟从18的间位移至20的邻位可逆转结合方向，使20的亲水性芳环在外部结合袋中取向，其中羧

  DOI：

  10.1021/jm030347n
• 作为产物：
  描述：

  三氟甲磺酸4-联苯基酯 在 XPhos 、 bis(2-phenylpyridinato)(2,2'-bipyridine)iridium(III) hexafluorophosphate 、 四丁基溴化铵 、 palladium diacetate 、 caesium carbonate 、 N,N-二异丙基乙胺 作用下， 以 甲醇 、 乙醚 、 N,N-二甲基乙酰胺 为溶剂， 20.0 ℃ 、101.33 kPa 条件下， 反应 4.5h， 生成 联苯-4-羧酸甲酯
  参考文献：
  名称：

  钯催化光催化氧化芳基和烯基三氟甲磺酸酯的羧基

  摘要：

  通过使用Pd和光氧化还原催化剂的组合，可见光驱动的芳基和烯基三氟甲磺酸酯与CO 2的羧化反应。该反应在温和的条件下进行，可用于多种底物，包括无环烯基三氟甲磺酸酯。

  DOI：

  10.1021/acs.orglett.9b01340
• 作为试剂：
  描述：

  苯基三氟甲烷磺酸酯 、 methyl 4-(tosyloxy)benzoate 在 Ni(TMHD)₂ 、 新铜试剂 、 联苯-4-羧酸甲酯 、 palladium diacetate 、 双(二环己基膦)甲烷 、 锌 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成 4,4'-二甲基联苯 、 4-甲基联苯
  参考文献：
  名称：

  两种苯酚衍生物之间的镍/钯双重催化的交叉还原偶联反应。

  摘要：

  可以容易地衍生自苯酚的底物之间的交叉偶联由于苯酚的含量高而极具吸引力。在这里，我们报道了芳基甲苯磺酸盐和芳基三氟甲磺酸酯之间双重的镍/钯催化的还原交叉偶联。可以从一个容易获得的苯酚中仅一步之遥就获得两种底物。该反应具有宽泛的官能团耐受性和底物范围（> 60个实例）。此外，它显示出对空间效应的低敏感性，这是通过合成2,2'-二取代的联芳基和完全取代的芳基产物证明的。天然产品和药品中苯酚的广泛存在使简单的后期功能化成为可能，例如ezetimibe和酪氨酸。

  DOI：

  10.1021/acs.orglett.0c02165

文献信息

• An alternative and facile purification procedure of amidation and esterification reactions using a medium fluorous Mukaiyama reagent
  作者：Masato Matsugi、Misaki Suganuma、Shoko Yoshida、Shohei Hasebe、Yoko Kunda、Kotaro Hagihara、Sayaka Oka

  DOI：10.1016/j.tetlet.2008.09.016

  日期：2008.11

  convenient methodology for the separation of a fluorous by-product using fluorous chemistry is described. A Mukaiyama coupling reagent bearing a medium fluorous tag, between 40% and 60% fluorine by weight, can be effectively separated from non-fluorous components by increasing the water content of the crude reaction mixture and subsequent filtration. Additional fluorous solid phase extraction is not necessary

  描述了一种使用氟化学分离氟副产物的简便方法。通过增加粗反应混合物的水含量并随后过滤，可以有效地将氟含量在40％至60％之间的带有中等氟标签的Mukaiyama偶联剂与非氟组分有效地分离。不需要额外的氟固相萃取。
• Hydroxyl radical-mediated oxidative cleavage of CC bonds and further esterification reaction by heterogeneous semiconductor photocatalysis
  作者：Hui Wang、Rui Jia、Mei Hong、Hongyan Miao、Bangqing Ni、Tengfei Niu

  DOI：10.1039/d1gc01931g

  日期：——

  developed by using tubular carbon nitride (TCN) as a general heterogeneous photocatalyst under an oxygen atmosphere with visible light irradiation. This protocol has an excellent substrate scope and gives the desired aldehydes, ketones and esters in moderate to high yields. Importantly, this metal-free procedure employed photogenerated hydroxyl radicals in situ as green oxidation active species, avoiding

  通过使用管状氮化碳（TCN）作为通用的多相光催化剂，在可见光照射下的氧气气氛下，开发了羟基自由基介导的烯烃有氧裂解和进一步的酯化反应制备羰基化合物。该方案具有出色的底物范围，并以中等至高产率提供所需的醛、酮和酯。重要的是，这种不含金属的程序原位使用光生羟基自由基作为绿色氧化活性物质，避免了目前的额外引发剂。该反应可在太阳光照射下进行，适用于大规模反应。此外，可回收的 TCN 催化剂可以多次使用而不会显着损失活性。
• Selective conversion of primary amides to esters promoted by KHSO4
  作者：Narsimha Sattenapally、Jhanvi Sharma、Yuqing Hou

  DOI：10.24820/ark.5550190.p010.392

  日期：——

  Primary amides, either aliphatic or aromatic, are easily converted to the corresponding esters via reflux in lower primary alcohols in the presence of KHSO4. Secondary amides lead to complicated mixtures under analogous conditions, whereas tertiary amides were inert. Use of isopropyl alcohol resulted in the formation of product at slower rate and lower yield along with side products, whereas, use of

  在 KHSO4 存在下，通过在低级伯醇中回流，脂肪族或芳香族伯酰胺很容易转化为相应的酯。仲酰胺在类似条件下会导致复杂的混合物，而叔酰胺是惰性的。异丙醇的使用导致产物的形成速度较慢，产率较低，同时副产物也较低，而使用叔醇不能成功转化，烯丙醇和苯甲醇提供了复杂的混合物。
• Gold(<scp>i</scp>)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes
  作者：Manjur O. Akram、Popat S. Shinde、Chetan C. Chintawar、Nitin T. Patil

  DOI：10.1039/c8ob00630j

  日期：——

  Gold(I)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes are described. This redox neutral strategy offers an efficient approach to diverse biaryls, vinyl arenes and arylacetylenes. Monitoring the reaction with NMR and ESI-MS provided strong evidence for the in situ formation of Ph3PAuIR (R = aryl, vinyl and alkynyl) species which is crucial for the activation of aryldiazonium

  描述了金（I）催化的芳基重氮盐与有机锡烷的交叉偶联反应。这种氧化还原中性策略为各种联芳基，乙烯基芳烃和芳基乙炔提供了一种有效的方法。用NMR和ESI-MS监测反应为原位形成Ph 3 PAu I R（R =芳基，乙烯基和炔基）物种提供了有力证据，这对于激活芳基重氮盐至关重要。
• Visible light-induced transformation of aldehydes to esters, carboxylic anhydrides and amides
  作者：Silvia Gaspa、Inês Raposo、Leonor Pereira、Gabriele Mulas、Pier Carlo Ricci、Andrea Porcheddu、Lidia De Luca

  DOI：10.1039/c9nj01984g

  日期：——

  A transition metal- and organophotocatalyst free synthesis of esters, carboxylic anhydrides and amides from aldehydes induced by visible-light has been reported. The proposed methodology can be carried out by the use of sunlight or artificial visible light as a blue LED source. The methodology has a very broad applicability and the desired products are obtained in very satisfactory yields.

  已经报道了由可见光诱导的从醛类到酯类，羧酸酐和酰胺类的无过渡金属和有机光催化剂的合成。可以通过使用阳光或人造可见光作为蓝色LED光源来执行所提出的方法。该方法具有非常广泛的适用性，并且以非常令人满意的产率获得了所需的产物。

表征谱图