2-(3-ethynyl-8-methylquinolin-6-yloxy)-N-(2-methoxyimino-1,1-dimethyl-ethyl)-2-methylsulfanylacetamide | 1128038-26-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 2-(3-ethynyl-8-methylquinolin-6-yloxy)-N-(2-methoxyimino-1,1-dimethyl-ethyl)-2-methylsulfanylacetamide
• 英文别名: 2-(3-ethynyl-8-methylquinolin-6-yl)oxy-N-(1-methoxyimino-2-methylpropan-2-yl)-2-methylsulfanylacetamide
• CAS: 1128038-26-5
• 化学式: C₂₀H₂₃N₃O₃S
• 分子量: 385.487
• InChiKey: XZYKBGYXJUFINL-UHFFFAOYSA-N

物化性质

• 密度：
  1.14±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  27
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  98.1
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  2-甲基-4-甲氧基苯胺 在 bis-triphenylphosphine-palladium(II) chloride 、 copper(l) iodide 、 N-羟基-7-氮杂苯并三氮唑 、 氢溴酸 、 potassium carbonate 、 溶剂黄146 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三乙胺 、 二异丙胺 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 69.5h， 生成 2-(3-ethynyl-8-methylquinolin-6-yloxy)-N-(2-methoxyimino-1,1-dimethyl-ethyl)-2-methylsulfanylacetamide
  参考文献：
  名称：

  Synthesis and fungicidal activity of quinolin-6-yloxyacetamides, a novel class of tubulin polymerization inhibitors

  摘要：

  A novel class of experimental fungicides has been discovered, which consists of special quinolin-6-yloxyacetamides. They are highly active against important phytopathogens, such as Phytophthora infestans (potato and tomato late blight), Mycosphaerella graminicola (wheat leaf blotch) and Uncinula necator (grape powdery mildew). Their fungicidal activity is due to their ability to inhibit fungal tubulin polymerization, leading to microtubule destabilization. An efficient synthesis route has been worked out, which allows the diverse substitution of four identified key positions across the molecular scaffold.

  DOI：

  10.1016/j.bmc.2014.06.015

文献信息

• Synthesis and fungicidal activity of quinolin-6-yloxyacetamides, a novel class of tubulin polymerization inhibitors
  作者：Clemens Lamberth、Fiona Murphy Kessabi、Renaud Beaudegnies、Laura Quaranta、Stephan Trah、Guillaume Berthon、Fredrik Cederbaum、Gertrud Knauf-Beiter、Valeria Grasso、Stephane Bieri、Andy Corran、Urvashi Thacker

  DOI：10.1016/j.bmc.2014.06.015

  日期：2014.8

  A novel class of experimental fungicides has been discovered, which consists of special quinolin-6-yloxyacetamides. They are highly active against important phytopathogens, such as Phytophthora infestans (potato and tomato late blight), Mycosphaerella graminicola (wheat leaf blotch) and Uncinula necator (grape powdery mildew). Their fungicidal activity is due to their ability to inhibit fungal tubulin polymerization, leading to microtubule destabilization. An efficient synthesis route has been worked out, which allows the diverse substitution of four identified key positions across the molecular scaffold.