cobalt(III) acetate | 917-69-1

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cobalt(III) acetate
• 英文别名: Cobaltic acetate；cobalt(3+);triacetate
• CAS: 917-69-1
• 化学式: C₆H₉CoO₆
• 分子量: 236.127
• InChiKey: ZUKDFIXDKRLHRB-UHFFFAOYSA-K

物化性质

• 熔点：
  99°C (rough estimate)
• 溶解度：
  溶于水、乙醇

计算性质

• 辛醇/水分配系数(LogP)：
  -3.73
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  120
• 氢给体数：
  0
• 氢受体数：
  6

ADMET

代谢

钴通过肺部、胃肠系统和皮肤被吸收。由于它是维生素B12（氰钴胺）的一个组成部分，因此它被分布到身体的大多数组织中。它在血液中运输，通常与白蛋白结合，肝脏和肾脏中的含量最高。钴主要通过尿液和粪便排出。

Cobalt is absorbed though the lungs, gastrointestinal tract, and skin. Since it is a component of the vitamin B12 (cyanocobalamin), it is distributed to most tissues of the body. It is transported in the blood, often bound to albumin, with the highest levels being found in the liver and kidney. Cobalt is excreted mainly in the urine and faeces. (L29)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 毒性总结

钴被认为通过氧化剂和自由基过程表现出其毒性。它产生氧自由基，并可能被氧化成离子态的钴，导致脂质过氧化增加、DNA损伤，并诱导某些酶，导致细胞凋亡。钴还被证明可以阻断无机钙通道，可能损害神经传递。钴还可以与硫辛酸螯合，损害丙酮酸或脂肪酸的氧化。此外，钴可能通过与锌指DNA修复蛋白相互作用来抑制DNA修复，并且已被证明可以抑制血红素合成和葡萄糖代谢。钴可能激活特定的辅助性T淋巴细胞，并直接与免疫蛋白（如抗体IgA和IgE或Fc受体）相互作用，导致免疫致敏。

Cobalt is believed to exhibit its toxicity through a oxidant-based and free radical-based processes. It produces oxygen radicals and may be oxidized to ionic cobalt, causing increased lipid peroxidation, DNA damage, and inducing certain enzymes that lead to cell apoptosis. Cobalt has also been shown to block inorganic calcium channels, possibly impairing neurotransmission. Cobalt can also chelate lipoic acids, impairing oxidation of pyruvate or fatty acids. In addition, cobalt may inhibit DNA repair by interacting with zinc finger DNA repair proteins, and has also been shown to inhibit heme synthesis and glucose metabolism. Cobalt may activate specific helper T-lymphocyte cells and interact directly with immunologic proteins, such as antibodies (IgA and IgE) or Fc receptors, resulting in immunosensitization. (L29)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 致癌物分类

2B，可能对人类有致癌性。

2B, possibly carcinogenic to humans. (L135)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 健康影响

接触高量的钴可以导致心脏、肺、肾脏和肝脏损伤。皮肤接触已知会导致接触性皮炎。钴也可能具有致突变和致癌作用。

Exposure to high amount of cobalt can cause heart, lung, kidney, and liver damage. Skin contact is known to result in contact dermatitis. Cobalt may also have mutagenic and carcinogenic effects. (L29, L30)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 暴露途径

吸入（L29）；口服（L29）；皮肤（L29）

Inhalational (L29) ; oral (L29) ; dermal (L29)

来源:Toxin and Toxin Target Database (T3DB)

毒理性

• 症状

钴吸入可能导致类似哮喘的呼吸问题。皮肤接触会导致接触性皮炎，其特征是刺激和皮疹。摄入大量钴可能会导致恶心和呕吐。

Cobalt inhalation can cause asthma-like breathing problems. Skin contact is known to result in contact dermatitis, which is characterized by irritation and rashes. Ingesting large amounts of cobalt may cause nausea and vomiting. (L2090)

来源:Toxin and Toxin Target Database (T3DB)

安全信息

• 储存条件：
  库房应保持低温、通风和干燥的环境。

制备方法与用途

生产方法

将357克（1.5摩尔）四水合二乙酸钴(II)加入到567毫升（6摩尔）乙酸酐和3升冰乙酸配成的溶液中，鼓泡通入用蒸汽稀释过的臭氧，然后放置过夜，形成墨绿色溶液。用氮气冲洗2小时后过滤，经硫代硫酸钠滴定表明，滤液中乙酸钴(III)的浓度为0.44摩尔/升。

类别

有毒物质

可燃性危险特性

可燃，在火场排出含氧化钴的辛辣刺激烟雾

储运特性

库房应低温、通风且干燥

灭火剂

水、二氧化碳、干粉或砂土

反应信息

• 作为反应物：
  描述：

  cobalt(III) acetate 以 溶剂黄146 为溶剂， 生成 cobalt(II) acetate
  参考文献：
  名称：

  CATALYST SYSTEMS FOR THE PRODUCTION OF ACIDS

  摘要：

  本发明的各种实施例通常涉及通过固定床催化氧化芳香族化合物来生产芳香族酸的新工艺，所述芳香族化合物带有至少一个可氧化取代基，该取代基直接连接到相应芳香族核的碳原子上。在一种实施例中，本发明的新氧化工艺包括以下步骤：a）在氧化催化剂的存在下，在气态氧源的存在下，催化氧化液相芳香族酸前体；b）分离成品；c）清除溶剂和氧化催化剂；d）可选地将至少一部分溶剂循环回氧化反应器；e）回收至少一部分氧化催化剂；f）将至少一部分氧化催化剂在固体充电催化剂床上重新充电；g）将再生的氧化催化剂送入氧化反应器。

  公开号：

  US20110108763A1
• 作为产物：
  描述：

  cobalt(II) acetate 生成 cobalt(III) acetate
  参考文献：
  名称：

  摘要：

  DOI：

文献信息

• Oxidation by cobalt(III) acetate. Part 6. A novel synthesis of the glycol monoacetates from aromatic olefins in wet acetic acid
  作者：Masao Hirano、Takashi Morimoto

  DOI：10.1039/p29840001033

  日期：——

  Oxidation of various aryl-conjugated olefins with cobalt(III) acetate in wet acetic acid under nitrogen affords the glycol monoacetates in moderate to good yields. None of the phenyl rearrangement product is formed in the present reactions. These results are best interpreted by assuming the formation of a Co-co-ordinated intermediate.

  在湿乙酸中，在氮气下用乙酸钴（III）在乙酸中氧化各种芳基共轭烯烃，可得到中等收率的乙二醇单乙酸酯。在本反应中没有形成苯基重排产物。通过假设形成一个协同中间体，可以最好地解释这些结果。
• Oxidation by Cobalt(III) Acetate. Part 13. Oxidation of Substituted Phenols with Cobalt(III) Acetate in Acetic Acid
  作者：Masao Hirano、Tadamichi Ishii、Takashi Morimoto

  DOI：10.1246/bcsj.64.1434

  日期：1991.4

  The oxidation of 2,6-di- and 2,4,6-tri-substituted phenols with cobalt(III) acetate has been investigated in acetic acid under an inert atmosphere; the former gave the corresponding diphenoquinones in excellent yields, and the latter yielded side-chain or nuclear acetoxylated products in moderate to good yields.

  2,6-二-和2,4,6-三-取代苯酚与乙酸钴（III）在惰性气氛下的乙酸中的氧化研究；前者以极好的收率产生相应的二苯醌，而后者以中等至良好的收率产生侧链或核乙酰氧基化产物。
• Novel metal-micelle asbestos and treatment of asbestos and other
  申请人：Flow General, Inc.

  公开号：US04401636A1

  公开（公告）日：1983-08-30

  Silicate minerals, including asbestos fibres, are rendered less harmful by forming metal-micelle polymer coatings on the silicate. A metal-micelle polymer coating is formed on a silicate by contacting a silicate mineral, such as asbestos, with a metal-weak base-strong acid aqueous ion system, or a metal-strong base-weak acid ion system. In these systems the metal is selected from the group consisting of manganese, chromium, cobalt, iron, copper, aluminum and mixtures of these metals. The product of reacting asbestos fibres with these systems is less irritating to living cells than asbestos fibres and also has substantially the same physical and chemical properties as asbestos fibres and can thus be substituted for asbestos fibres in most technological applications.

  硅酸盐矿物，包括石棉纤维，通过在硅酸盐上形成金属胶束聚合物涂层而变得不那么有害。通过将硅酸盐矿物（如石棉）与金属弱碱-强酸水离子体系或金属强碱-弱酸离子体系接触，可以在硅酸盐上形成金属胶束聚合物涂层。在这些体系中，金属选自锰、铬、钴、铁、铜、铝和这些金属的混合物。用这些体系处理石棉纤维的产物对生物细胞的刺激性较小，而且在大多数技术应用中可以代替石棉纤维，因为它具有与石棉纤维基本相同的物理和化学特性。
• Catalyst systems for the production of acids
  申请人：Ball George A.

  公开号：US08658820B2

  公开（公告）日：2014-02-25

  Various embodiments of the invention herein described generally relate to novel processes for the production of aromatic acids by fixed bed catalytic oxidation of aromatic compounds carrying at least one oxidizable substituent group attached directly to the carbon atom of the corresponding aromatic nucleus. In an embodiment, a novel oxidation process of the present invention comprises the steps of: a) catalytically oxidizing, with an oxidation catalyst, a liquid phase aromatic acid precursor in the presence of a gaseous oxygen source; b) separating a finished product; c) purging the solvent and the oxidation catalyst; d) optionally recycling at least a portion of the solvent into the oxidation reactor; e) recovering at least a portion of the oxidation catalyst; f) recharging the at least a portion of the oxidation catalyst over a solid recharging catalyst bed; and (g) feeding a reactivated oxidation catalyst to the oxidation reactor.

  本发明的各种实施例通常涉及通过固定床催化氧化芳香族化合物生产芳香族酸的新工艺，该芳香族化合物直接连接到相应芳香族核的碳原子上，且至少带有一个可氧化取代基团。在一种实施例中，本发明的新氧化工艺包括以下步骤：a）在氧化催化剂的催化下，在气态氧源的存在下催化氧化液相芳香族酸前体；b）分离成品；c）清除溶剂和氧化催化剂；d）可选地将至少一部分溶剂循环回氧化反应器；e）回收至少一部分氧化催化剂；f）在固体再生催化剂床上对至少一部分氧化催化剂进行再充电；和（g）将再生的氧化催化剂送入氧化反应器。
• Hirano, Masao; Nakamura, Kouji; Morimoto, Takashi, Journal of the Chemical Society. Perkin transactions II, 1981, p. 817 - 820
  作者：Hirano, Masao、Nakamura, Kouji、Morimoto, Takashi

  DOI：——

  日期：——