毒理性
使用plicamycin进行化疗会导致几乎所有治疗超过1到2天并在治疗期间接受监测的患者血清酶水平升高。血清ALT、AST和LDH值在第一次输注后的3天内开始上升，并在7到10天内达到峰值，水平为正常上限(ULN)的5到500倍。然而，这些升高是暂时的，在1到3周内解决，很少伴有症状或黄疸。在这些发作期间进行的肝脏活检通常显示中央小叶坏死和充血。随着治疗的重复进行，升高的情况通常会继续发生，程度相同或更轻。有一例报告称，一名患者因非恶性高钙血症接受全剂量plicamycin治疗4天后，出现了急性肝衰竭，提示可能是缺血性肝炎或窦状阻塞综合征。尽管如此，血清酶升高的情况虽然从中度到重度不等，但都是暂时的和良性的。
Chemotherapy with plicamycin causes serum enzyme elevations in almost all patients who are treated for more than 1 or 2 days and who are monitored during therapy. Serum ALT, AST and LDH values begin to rise within 3 days of the first infusion and peak within 7 to 10 days at levels of 5 to 500 times the upper limit of the normal range (ULN). The elevations, however, are transient and resolve within 1 to 3 weeks and are rarely associated with symptoms or jaundice. Liver biopsies taken during these episodes usually demonstrate centrolobular necrosis and congestion. With repeated courses, elevations continue to occur generally to the same or lesser degree. A single instance of acute liver failure arising within days of therapy that was suggestive of ischemic hepatitis or sinusoidal obstruction syndrome has been reported in a patient treated with full doses of plicamycin for 4 days for nonmalignant hypercalcemia. Otherwise, the serum enzyme elevations, despite being moderate to severe, are transient and benign.
来源:LiverTox
