dodeca-2,4,6,8,10-pentaenal | 53193-45-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: dodeca-2,4,6,8,10-pentaenal
• CAS: 53193-45-6
• 化学式: C₁₂H₁₄O
• 分子量: 174.243
• InChiKey: NLPJEWTYXLOFLM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  dodeca-2,4,6,8,10-pentaenal 生成 十二醛
  参考文献：
  名称：

  Fischer; Hultzsch; Flaig, Chemische Berichte, 1937, vol. 70, p. 372

  摘要：

  DOI：
• 作为产物：
  描述：

  5-乙氧基-辛-2,6-二烯醛 在 磷酸 、 三氟化硼乙醚 作用下， 生成 dodeca-2,4,6,8,10-pentaenal
  参考文献：
  名称：

  Krasnaya,Zh.A.; Kucherov,V.F., Journal of general chemistry of the USSR, 1960, vol. 30, p. 3875 - 3882

  摘要：

  DOI：

文献信息

• An Evolution of Drug Development and Clinical Pharmacology during the 20th Century
  作者：Gene Heath、Wayne A. Colburn

  DOI：10.1177/00912700022009657

  日期：2000.9

  The current state of clinical pharmacology and drug development did not just happen. Clinical pharmacology and the drug development process were born, evolved, and have come to the fore during the past 100 years. The past century has been one of accelerating progress in science and medicine. The progress has not been a straight line but rather more like a sidewinder moving across the desert. Drug development has moved from small experiments with concoctions, extracts, and potions along with the manufacturing and promotion of the purported remedies to processes that exploited unknowing patients to a process that now requires concept generation, discovery, research, planning, and development with many checks and balances for the protection of human subjects. The factors that contributed to this progression from inappropriate use of potions, concoctions, and snake oil to the highly regulated drug development process of today is described in some detail.

  临床药理学与药物开发的现状并非偶然形成。临床药理学和药物开发过程在过去100年间诞生、发展并逐渐占据重要地位。过去一个世纪，科学与医学的进步不断加速。这种进步并非直线前行，更像是在沙漠中蜿蜒前进的侧风行者。药物开发从早期的小规模实验，涉及调制品、提取物和药剂，以及制造和推广所谓的疗法，发展到利用不知情的患者进行实验，再到现在需要概念生成、发现、研究、规划和开发，并设立众多制衡机制以保护人类受试者的现代高度规范化的药物开发过程。本章将详细描述从早期不当使用药剂、调制品和江湖医术到今日高度规范化的药物开发过程的演进因素。
• Electronic energy levels in a homologous series of unsubstituted linear polyenes
  作者：Kevin L. D'Amico、Christopher Manos、Ronald L. Christensen

  DOI：10.1021/ja00526a003

  日期：1980.3

  Abstract: Absorption, emission, and excitation spectra of 1,3,5,7-octatetraene, 1,3,5,7,9-decapentaene, and 1,3,5,7,9,1 l-dode- cahexaene have been obtained in room temperature solutions and 77 K glasses. All spectra exhibit the characteristic gap be- tween the origin of the strongly allowed absorption ('Ag - 'B,) and the origin of fluorescence ('Ag* - 'A!): Comparison with results previously obtained

  摘要：1,3,5,7-辛四烯、1,3,5,7,9-十碳烯和 1,3,5,7,9,1-l-十二碳六烯的吸收、发射和激发光谱具有在室温溶液和 77 K 玻璃中获得。所有光谱都表现出强烈允许吸收的起源 ('Ag - 'B,) 和荧光起源 ('Ag* - 'A!) 之间的特征差距：与先前获得的甲基取代多烯结果的比较显示'B,-'Ag* 能隙是取代度的敏感函数。溶剂效应研究已用于将未取代多烯的转变能外推到气相条件。对于四烯、戊烯和己烯，'Bu-IAg* 能量差分别为 6380、7050 和 7420 cm-I。这些结果根据多烯电子状态的当前理论描述进行了讨论。1. 引言 线性共轭 T 电子系统近年来受到了新的实验和理论兴趣。这种兴趣在很大程度上是由多烯电子态在几个重要的光生物过程中发挥的重要作用激发的。对于凝聚相中的长多烯（具有三个以上双键的），现在有大量证据表明存在低位的、低于 'B 的 'Ag*
• SYNTHESIS OF 2-SUBSTITUTED THIAZOLIDINE-4-CARBOXYLIC ACIDS
  作者：Elena Pini、Donatella Nava、Riccardo Stradi

  DOI：10.1080/00304940409355390

  日期：2004.4

  organic phase was separated, and the aqueous phase was extracted with CI-L$l, (2 x 15 mL). The combined organic phases were washed with water, saturated brine and dried (N%S04). The solvent was evaporated under reduced pressure to give the crude product, which was recrystallized from methanol-ether to afford 6 (0.75 g, 84 %) as a yellow solid, mp. 194195"C, [a]: = +43T (c 3, pyridine), lit.4 192°C;

  分离有机相，水相用Cl-L 1 (2 x 15 mL)萃取。用水、饱和盐水洗涤合并的有机相并干燥(N%SO 4 )。减压蒸发溶剂得到粗产物，将其从甲醇-乙醚中重结晶得到黄色固体6(0.75g，84％)，mp。194195"C, [a]: = +43T (c 3, 吡啶), lit.4 192°C; [a]iO = +43.8"C (c 3.08, 吡啶); IR (KBr): 3364,3061, 1598, 1515, 1350, 1215,765 cm-'; 'H NMR (CDCl,): 6 1.55 (s, 2H, NHJ, 2.88-2.90 (t, 1H, CH), 3.073.33 (m, 2H, CHJ, 4.09 (s, 1H, OH), 4.69-4.70 (d, IH, CH), 7.24-8.05 (m, 19H, ArH); I3C NMR
• Thermodynamic studies of hydrogen bonding and proton transfer between weak acids and bases in nonaqueous solvents as a model for acid-base reactions in proteins
  作者：Paul E. Blatz、Jay A. Tompkins

  DOI：10.1021/ja00036a049

  日期：1992.5

  Dilute solutions of phenol and CH 3 (CH=CH) 5 CH=NC 4 H 9 (compound 1) in hydrocarbon solvents are subjected to decreasing temperature and their electronic absorption spectra recorded. Initially only the spectrum of the Schiff base, compound 1, is present. As temperature is lowered, absorbance decreases and the spectrum of the H-bonded form of 1 appears. Continued lowering causes a decrease in absorption

  苯酚和 CH 3 (CH=CH) 5 CH=NC 4 H 9（化合物 1）在烃溶剂中的稀溶液经受降低的温度并记录它们的电子吸收光谱。最初只存在席夫碱化合物 1 的光谱。随着温度降低，吸光度降低，出现 1 的氢键形式的光谱。持续降低导致氢键形式的吸收减少，并导致 1 的质子转移形式的吸收增加
• Polyene carboxylic acids and esters and manufacture thereof
  申请人：WINTHROP CHEM CO INC

  公开号：US02175843A1

  公开（公告）日：1939-10-10