phenylalanine | 62056-68-2

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 苯丙氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: phenylalanine
• 英文别名: Alanin-phenylester；alanine phenyl ester；(+/-)-2-Amino-propionsaeure-phenylester；Phenyl 2-aminopropanoate
• CAS: 62056-68-2
• 化学式: C₉H₁₁NO₂
• 分子量: 165.192
• InChiKey: HCRMTRJXSDDOIK-UHFFFAOYSA-N

物化性质

• 沸点：
  262.6±23.0 °C(Predicted)
• 密度：
  1.118±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenylalanine 、 丙酮酸 在 三氯氧磷 作用下， 生成 N-Pyruvoyl-alanin-phenylester
  参考文献：
  名称：

  Wieland,T. et al., Chemische Berichte, 1960, vol. 93, p. 3027 - 3035

  摘要：

  DOI：
• 作为产物：
  描述：

  Z-Ala-OC6H5 在 氢溴酸 作用下， 以 溶剂黄146 为溶剂， 生成 phenylalanine
  参考文献：
  名称：

  Wieland,T. et al., Chemische Berichte, 1960, vol. 93, p. 3027 - 3035

  摘要：

  DOI：

文献信息

• FATTY ACID ANTIVIRAL CONJUGATES AND THEIR USES
  申请人：Catabasis Pharmaceuticals, Inc.

  公开号：US20140288025A1

  公开（公告）日：2014-09-25

  The invention relates to fatty acid antiviral conjugates; compositions comprising an effective amount of a fatty acid antiviral conjugate; and methods for treating or preventing a viral infection comprising the administration of an effective amount of a fatty acid antiviral conjugate.

  这项发明涉及脂肪酸抗病毒共轭物；包含有效量脂肪酸抗病毒共轭物的组合物；以及治疗或预防病毒感染的方法，包括给予有效量脂肪酸抗病毒共轭物的管理。
• ISOTOPE-ENRICHED 3-AMINO-1-PROPANESULFONIC ACID DERIVATIVES AND USES THEREOF
  申请人：Risen (Suzhou) Pharma Tech Co., Ltd.

  公开号：US20180273471A1

  公开（公告）日：2018-09-27

  There are provided isotope-enriched compounds of Formula (I) and pharmaceutically acceptable salts or esters thereof, as well as pharmaceutical compositions thereof and methods of use thereof for prevention and treatment of amyloid-β related diseases, such as Alzheimer's disease. R 1 R 2 X—CR 2 —CH 2 —CH 2 —SO 3 H   (I)

  提供了式（I）的同位素富集化合物及其药用可接受的盐或酯，以及用于预防和治疗与淀粉样蛋白β相关疾病（如阿尔茨海默病）的药物组合物和使用方法。
• [EN] NOVEL PRODRUGS OF NUCLEOSIDE PHOSPHONATES<br/>[FR] NOUVEAUX PROMÉDICAMENTS DE PHOSPHONATES NUCLÉOSIDIQUES
  申请人：UNIV LEUVEN KATH

  公开号：WO2018172416A1

  公开（公告）日：2018-09-27

  The present invention relates to novel phosphonoamidate prodrugs. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the herpes simplex virus 1, herpes simplex virus 2, human cytomegalovirus, varicella zoster virus, vaccinia virus and adenovirus.

  本发明涉及新型磷酸酰胺前药。本发明还涉及使用这些新型磷酸酯修饰核苷酸来治疗或预防病毒感染以及它们用于制造用于治疗或预防病毒感染的药物，特别是用于疱疹病毒1型、疱疹病毒2型、人类巨细胞病毒、水痘带状疱疹病毒、牛痘病毒和腺病毒等病毒感染。
• N-Acetyl-(R,S)-beta-Amino Acid Acylase Gene
  申请人：Suzuki Shunichi

  公开号：US20080241895A1

  公开（公告）日：2008-10-02

  The present invention provides genes that encode the N-acetyl-(R,S)-β-amino acid acylases. The N-acetyl-(R,S)-β-amino acid acylases were isolated and purified from bacterial cells and the nucleotide sequences were determined. A host, such as Escherichia coli , was used to construct a high-expression system for these genes. The N-acetyl-(R)-β-amino acid acylase produced by Burkholderia sp. AJ110349 (FERM BP-10366) includes, for example, the protein having the amino acid sequence shown in SEQ. ID. NO. 8. The gene encoding this enzyme includes, for example, the DNA having the nucleotide sequence as shown in SEQ. ID. NO. 7. The N-acetyl-(S)-β-amino acid acylase produced by Burkholderia sp. AJ110349 (FERM BP-10366) includes, for example, the protein having the amino acid sequence shown in SEQ. ID. NO. 10. The gene encoding this enzyme includes, for example, the DNA having the nucleotide sequence shown inshown in SEQ. ID. NO. 9. The N-acetyl-(R)-β-amino acid acylase produced by Variovorax sp. AJ110348 (FERM BP-10367) includes, for example, the protein comprised of the amino acid sequence shown in SEQ. ID. NO. 12. The gene encoding this enzyme includes, for example, the DNA having the nucleotide sequence shown inshown in SEQ. ID. NO. 11.

  本发明提供了编码N-乙酰-(R,S)-β-氨基酸酰化酶的基因。N-乙酰-(R,S)-β-氨基酸酰化酶从细菌细胞中分离和纯化，并确定了核苷酸序列。宿主，例如大肠杆菌，被用于构建这些基因的高表达系统。Burkholderia sp. AJ110349 (FERM BP-10366)产生的N-乙酰-(R)-β-氨基酸酰化酶，例如包括具有SEQ. ID. NO. 8所示的氨基酸序列的蛋白质。编码这种酶的基因，例如包括具有SEQ. ID. NO. 7所示的核苷酸序列的DNA。Burkholderia sp. AJ110349 (FERM BP-10366)产生的N-乙酰-(S)-β-氨基酸酰化酶，例如包括具有SEQ. ID. NO. 10所示的氨基酸序列的蛋白质。编码这种酶的基因，例如包括具有SEQ. ID. NO. 9所示的核苷酸序列的DNA。Variovorax sp. AJ110348 (FERM BP-10367)产生的N-乙酰-(R)-β-氨基酸酰化酶，例如包括由SEQ. ID. NO. 12所示的氨基酸序列组成的蛋白质。编码这种酶的基因，例如包括具有SEQ. ID. NO. 11所示的核苷酸序列的DNA。
• Amino-acid amide derivatives, agricultural or horticultural fungicides,
  申请人：Kumiai Chemical Industry Co., Ltd.

  公开号：US05574064A1

  公开（公告）日：1996-11-12

  The present invention provides an agricultural or horticultural fungicide including an effective amount of an amino-acid derivative represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkyl group (optionally having at least one same or different substituent of a halogen atom, an alkoxy group, and a cyano group), R.sup.2 represents an ethyl group, or an n-propyl group, R.sup.3 represents a hydrogen atom or a lower alkyl group, R.sup.4 represents a hydrogen atom, R.sup.5, R.sup.6, and R.sup.7 independently represent a hydrogen atom or a lower alkyl group, R.sup.8 represents a hydrogen atom, or a lower alkyl group, Z.sup.1 and Z.sup.2 independently represent an oxygen atom or a sulfur atom, Z.sup.3 represents an oxygen atom, or a sulfur atom, Q represents a phenyl group, m represents an integer from 0 to 2, and n represents 0 or 1. The amino-acid amide derivatives according to the present invention exhibit superior control of cucumber downy mildew (Pseudoperonospora cubensis), tomato late blight (Phytophthora infestans), and grape downy mildew (Plasmopara viticola), and are effective for potato late blight (Phytophthora infestans). In addition, the agricultural or horticultural fungicides of the present invention are also characterized in that they are not harmful chemicals and exhibit excellent characteristics such as systemic action, residual activity, and persistence after rain-fall.

  本发明提供了一种农业或园艺杀菌剂，包括有效量的氨基酸衍生物，其表示为以下公式：其中，R1表示较低的烷基（可选择具有至少一个相同或不同的卤素原子、烷氧基和氰基的取代基），R2表示乙基基团或正丙基基团，R3表示氢原子或较低的烷基，R4表示氢原子，R5、R6和R7独立地表示氢原子或较低的烷基，R8表示氢原子或较低的烷基，Z1和Z2独立地表示氧原子或硫原子，Z3表示氧原子或硫原子，Q表示苯基，m表示0到2的整数，n表示0或1。本发明的氨基酸酰胺衍生物表现出优异的黄瓜霜霉病（Pseudoperonospora cubensis）、番茄晚疫病（Phytophthora infestans）和葡萄霜霉病（Plasmopara viticola）控制效果，并且对土豆晚疫病（Phytophthora infestans）有效。此外，本发明的农业或园艺杀菌剂还具有不会对人体有害的特性，并且表现出系统作用、残留活性和雨后持久性等优异特性。