5-溴-2'-氯-2-羟基苯甲酮 | 332104-54-8

• 物质功能分类: 有机原料 - 酮类化合物
• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 5-溴-2'-氯-2-羟基苯甲酮
• 中文别名: 5-溴-2′-氯-2-羟基二苯甲酮；5-溴-2’-氯-2-羟基苯甲酮
• 英文名称: 5-bromo-2'-chloro-2-hydroxybenzophenone
• 英文别名: (5-bromo-2-hydroxyphenyl)-(2-chlorophenyl)methanone
• CAS: 332104-54-8
• 化学式: C₁₃H₈BrClO₂
• 分子量: 311.562
• InChiKey: JTYCQJZUXZTAEK-UHFFFAOYSA-N

物化性质

• 熔点：
  104-108 °C(lit.)
• 沸点：
  398.4±32.0 °C(Predicted)
• 密度：
  1.605±0.06 g/cm3(Predicted)
• 稳定性/保质期：
  在常温常压下稳定，应避免与强氧化剂接触。

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  37.3
• 氢给体数：
  1
• 氢受体数：
  2

安全信息

• 危险品标志：
  Xi
• 海关编码：
  2914700090

反应信息

• 作为反应物：
  描述：

  5-溴-2'-氯-2-羟基苯甲酮 在 potassium carbonate 、 sodium hydroxide 作用下， 以 四氢呋喃 、 丙酮 为溶剂， 反应 0.5h， 生成 5-bromo-3-(2-chlorophenyl)-1-benzofuran-2-carboxylic acid
  参考文献：
  名称：

  Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels

  摘要：

  Improved experimental conditions were carried out for the preparation in high yields of some 3-phenyl-1-benzofuran-2-carboxylic acids, potent inhibitors of C1C-K chloride channels. A one-pot condensation-cyclization was set up starting from different 2-hydroxybenzophenones whose reactivity was significantly affected from the electronic properties of their substituents.

  DOI：

  10.3987/com-10-12070

文献信息

• LUBRICIOUS COATINGS FOR MEDICAL DEVICES
  申请人：Sandhu Shivpal S.

  公开号：US20120059111A1

  公开（公告）日：2012-03-08

  Substrates may be coated with copolymers of N-vinyl pyrrolidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.

  基材可以涂覆N-乙烯基吡咯烷酮和芳基酮的共聚物。本文描述了一种制备高分子量的共聚物的方法，其中酮随机分散在共聚物中。
• Lubricious coatings for medical devices
  申请人：Biointeractions Ltd.

  公开号：EP2613819A1

  公开（公告）日：2013-07-17
• US8541498B2
  申请人：——

  公开号：US8541498B2

  公开（公告）日：2013-09-24
• [EN] Lubricious coatings for medical devices<br/>[FR] REVÊTEMENTS LUBRIFIANTS POUR DISPOSITIFS MÉDICAUX
  申请人：BIOINTERACTIONS LTD

  公开号：WO2012032283A1

  公开（公告）日：2012-03-15

  Substrates may be coated with copolymers of N-vinyl pyrroiidinone and aryl ketones. Processes are described for making the copolymers at high molecular weight with the ketones randomly dispersed on the copolymer.
• Convenient Synthesis of Some 3-Phenyl-1-benzofuran-2-carboxylic Acid Derivatives as New Potential Inhibitors of CLC-Kb Channels
  作者：Fulvio Loiodice、Luca Piemontese、Giuseppe Carbonara、Giuseppe Fracchiolla、Antonio Laghezza、Paolo Tortorella

  DOI：10.3987/com-10-12070

  日期：——

  Improved experimental conditions were carried out for the preparation in high yields of some 3-phenyl-1-benzofuran-2-carboxylic acids, potent inhibitors of C1C-K chloride channels. A one-pot condensation-cyclization was set up starting from different 2-hydroxybenzophenones whose reactivity was significantly affected from the electronic properties of their substituents.