6-bromo-3-phenyl-2-[2-(7H-purin-6-ylamino)ethyl]chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 6-bromo-3-phenyl-2-[2-(7H-purin-6-ylamino)ethyl]chromen-4-one
• 化学式: C₂₂H₁₆BrN₅O₂
• 分子量: 462.3
• InChiKey: PZVZCQDBWYONNZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  30
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  92.8
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• [EN] PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2- (1 -HYDROXY- ALKYL) - CHROMEN - 4 - ONE DERIVATIVES AND THEIR USE IN PREPARING PHARMACEUTICALS<br/>[FR] PROCÉDÉ DE PRÉPARATION DE DÉRIVÉS OPTIQUEMENT PURS ET ÉVENTUELLEMENT SUBSTITUÉS DE 2- (1 -HYDROXY- ALKYL) - CHROMEN - 4 - ONE ET LEUR UTILISATION DANS LA PRÉPARATION DE PRODUITS PHARMACEUTIQUES
  申请人：RHIZEN PHARMACEUTICALS SA

  公开号：WO2013164801A1

  公开（公告）日：2013-11-07

  The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure optionally substituted 2-(1-hydroxy-alkyl)- chromen-4-one derivatives represented by formula (IA) and (IB), processes for preparing the alcohol derivatives and their use in preparing pharmaceuticals.

  本发明涉及一种作为药物中间体有用的化合物，用于制备中间体的过程，用于该过程的中间体以及中间体在制备药物中的应用。特别地，本发明涉及对映纯的、可选择取代的2-(1-羟基-烷基)-香豆素衍生物，其化学式为（IA）和（IB），用于制备醇衍生物的过程以及它们在制备药物中的应用。
• PROCESS FOR PREPARATION OF OPTICALLY PURE AND OPTIONALLY SUBSTITUTED 2- (1 -HYDROXY- ALKYL) - CHROMEN - 4 - ONE DERIVATIVES AND THEIR USE IN PREPARING PHARMACEUTICALS
  申请人：Rhizen Pharmaceuticals S.A.

  公开号：EP2844647A1

  公开（公告）日：2015-03-11
• PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR
  申请人：Rhizen Pharmaceuticals S.A.

  公开号：EP2916868A1

  公开（公告）日：2015-09-16
• [EN] PHARMACEUTICAL COMPOSITIONS CONTAINING A PDE4 INHIBITOR AND A PI3 DELTA OR DUAL PI3 DELTA-GAMMA KINASE INHIBITOR<br/>[FR] COMPOSITIONS PHARMACEUTIQUES CONTENANT UN INHIBITEUR DE PDE4 ET UN INHIBITEUR DE PI3 KINASE DELTA OU UN DOUBLE INHIBITEUR DE PI3 KINASE DELTA ET GAMMA
  申请人：RHIZEN PHARMACEUTICALS SA

  公开号：WO2014072937A1

  公开（公告）日：2014-05-15

  This present invention relates to a method of treating a autoimmune, respiratory and/or inflammatory disease or condition (e.g., psoriasis, rheumatoid arthritis, asthma, COPD). The method comprises administering a PI3K Delta inhibitor or a dual PI3K Delta- Gamma inhibitor and a PDE4 inhibitor. The present invention also relates to pharmaceutical compositions containing a PI3K Delta or dual PI3K Delta-Gamma inhibitor and a PDE4 inhibitor.