6-(2-甲氧基-4,5-亚甲二氧基苯基)-7H-呋喃并[3,2-g][1]苯并吡喃-7-酮 | 10091-01-7

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 中文名称: 6-(2-甲氧基-4,5-亚甲二氧基苯基)-7H-呋喃并[3,2-g][1]苯并吡喃-7-酮
• 中文别名: 6-(6-甲氧基-1,3-苯并二噁唑-5-基)-7H-呋喃并[3,2-g]色烯-7-酮
• 英文名称: pachyrrhizin
• 英文别名: 6-(6-methoxy-1,3-benzodioxol-5-yl)furo[3,2-g]chromen-7-one
• CAS: 10091-01-7
• 化学式: C₁₉H₁₂O₆
• 分子量: 336.301
• InChiKey: PENSQRMNZZWMGV-UHFFFAOYSA-N

物化性质

• 熔点：
  207 °C
• 沸点：
  541.4±50.0 °C(Predicted)
• 密度：
  1.453±0.06 g/cm3(Predicted)
• 物理描述：
  Solid
• 碰撞截面：
  170.7 Ų [M+H]+ [CCS Type: TW, Method: calibrated with polyalanine and drug standards]

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  25
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  67.1
• 氢给体数：
  0
• 氢受体数：
  6

安全信息

• 海关编码：
  2932999099

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 四氯化碳 、 N-溴代丁二酰亚胺(NBS) 、 过氧化苯甲酰 作用下， 生成 6-(2-甲氧基-4,5-亚甲二氧基苯基)-7H-呋喃并[3,2-g][1]苯并吡喃-7-酮
  参考文献：
  名称：

  The synthesis of pachyrrhizin

  摘要：

  DOI：

  10.1016/s0040-4039(01)99482-1

文献信息

• COMPOSITIONS AND METHODS FOR THE TREATMENT OF PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY (PML)
  申请人：Biogen MA Inc.

  公开号：EP3025714A1

  公开（公告）日：2016-06-01

  The invention relates to compositions, methods, and kits for treating subjects infected by or at risk of infection with a DNA virus (e.g., a JC Virus or a BK virus). Aspects of the invention are useful to prevent or treat DNA virus associated conditions (e.g., PML) in subjects that are immunocompromised. Compositions are provided that inhibit intracellular replication of DNA viruses.

  本发明涉及治疗受 DNA 病毒（如 JC 病毒或 BK 病毒）感染或有感染风险的受试者的组合物、方法和试剂盒。本发明的各个方面可用于预防或治疗免疫功能低下的受试者与 DNA 病毒相关的病症（如 PML）。本发明提供了抑制 DNA 病毒细胞内复制的组合物。
• COMPOUNDS, COMPOSITIONS AND METHODS FOR PREVENTING SKIN DARKENING
  申请人：Orlow Seth J.

  公开号：US20110190229A1

  公开（公告）日：2011-08-04

  A method for preventing hyperpigmented skin, undesired pigmentation disorder of skin, or undesired darkening of skin using coumarin compounds, the use of such compounds, and compositions and formulations thereof are disclosed. In a particular embodiment, the coumarin compounds are selected from robustic acid methyl ether, scandenin, and coumophos. The compounds may be prepared as additives to pharmaceutical and cosmetic compositions, and in personal care products such as antiperspirants. In a particular embodiment extends to an antiperspirant product containing a skin darkening inhibitory amount of a compound of the invention. Also, the present skin darkening compounds may be prepared in combination with each other. The compounds, compositions and formulations of the invention may be used for the prevention of the onset or progression of conditions characterized by unwanted skin darkening, including those that may be causally related to aberrant melanogenesis activity including, by way of non-limiting example, hyperpigmentation and others.
• COUMARIN COMPOUNDS AS MELANOGENESIS MODIFIERS AND USES THEREOF
  申请人：ORLOW Seth J.

  公开号：US20120220545A1

  公开（公告）日：2012-08-30

  Provided are coumarin compounds of formula I, for example, robustic acid methyl ether, and the use of such compounds and compositions thereof to modulate (e.g., inhibit) melanogenesis and pigmentation. wherein R 3 , R 4 , R 5 , R 6 , R 7 and R 8 are described herein. Also provided are plant extracts containing a compound of formula I, and the use of such a plant extract to modulate (e.g., inhibit) melanogenesis and pigmentation. The compound or plant extract may be prepared as pharmaceutical and cosmetic compositions, and may be used for the prevention and treatment of conditions that are related to aberrant melanogenesis activity.
• US8563754B2
  申请人：——

  公开号：US8563754B2

  公开（公告）日：2013-10-22
• US8772252B2
  申请人：——

  公开号：US8772252B2

  公开（公告）日：2014-07-08