2-phenylethyl β-D-thiogalactoside | 63407-54-5

• 物质功能分类: 生物化工 - 糖类化合物 - 单糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-phenylethyl β-D-thiogalactoside
• 英文别名: 1-Phenethyl-1-thio-β-D-galactopyranosid；phenethyl-(1-thio-β-D-galactopyranoside)；Phenaethyl-(1-thio-β-D-galactopyranosid)；2-Phenylethyl 1-Thio-Beta-D-Galactopyranoside；(2R,3R,4S,5R,6S)-2-(hydroxymethyl)-6-(2-phenylethylsulfanyl)oxane-3,4,5-triol
• CAS: 63407-54-5
• 化学式: C₁₄H₂₀O₅S
• 分子量: 300.376
• InChiKey: ZNAMMSOYKPMPGC-HTOAHKCRSA-N

物化性质

• 熔点：
  100 °C
• 沸点：
  539.7±50.0 °C(Predicted)
• 密度：
  1.39±0.1 g/cm3(Predicted)
• 溶解度：
  甲醇：50 mg/mL，澄清，无色
• 稳定性/保质期：
  远离氧化物和强酸。

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  115
• 氢给体数：
  4
• 氢受体数：
  6

安全信息

• 安全说明：
  S22,S24/25
• WGK Germany：
  3
• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 甲醇 、 sodium methylate 作用下， 生成 2-phenylethyl β-D-thiogalactoside
  参考文献：
  名称：

  Helferich; Tuerk, Chemische Berichte, 1956, vol. 89, p. 2215,2218

  摘要：

  DOI：

文献信息

• Monitoring of cells and trans-activating transcription elements
  申请人：THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

  公开号：EP0336626A1

  公开（公告）日：1989-10-11

  Methods and compositions are provided for analyzing in viable cells gene expression regulatory elements and systems. The method can be used to evaluate a transcriptional initiation regulatory system or the presence of a trans acting component. The method finds use in evaluating various transcriptional initiation functional sequences for use in expression of products, for the detection of trans acting agents associated with viruses and for quantitating the presence of infectious viruses. The method comprises introducing an expression cassette encoding an enzyme which has a fluorescent substrate, substantially irreversibly introducing the substrate into the cell host and detecting the formation of fluorescence during a predetermined time interval.

  本研究提供了分析有活力细胞中基因表达调控元件和系统的方法和组合物。该方法可用于评估转录起始调控系统或反式作用成分的存在。该方法可用于评估用于表达产品的各种转录起始功能序列、检测与病毒有关的反式作用因子以及量化传染性病毒的存在。该方法包括引入编码具有荧光底物的酶的表达盒，基本上不可逆地将底物引入细胞宿主，并在预定的时间间隔内检测荧光的形成。
• Compartmentalised combinatorial chemistry by microfluidic control
  申请人：Medical Research Council

  公开号：EP2556883A1

  公开（公告）日：2013-02-13

  The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control. The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.

  本发明描述了一种合成化合物的方法，包括以下步骤(a) 将两组或两组以上的初级化合物分隔成微胶囊；使一定比例的微胶囊含有两种或两种以上的化合物；以及 (b) 通过来自不同组的初级化合物之间的化学反应在微胶囊中形成次级化合物；其中步骤(a)和步骤(b)中的一个或两个是在微流体控制下进行的；最好是电子微流体控制。本发明还可进一步鉴定与生化系统的目标成分结合或调节目标活性的化合物，并将其共同分装到微胶囊中。
• Platelet additive solution having a beta-galactosidase inhibitor
  申请人：Velico Medical, Inc.

  公开号：US10271541B2

  公开（公告）日：2019-04-30

  The present invention relates to a platelet additive solution (PAS) having an amount of one or more β-galactosidase inhibitors with or without an amount of one or more sialidase inhibitors, and optionally one or more glycan-modifying agents; and one or more of PAS components that include a salt, a citrate source, a carbon source, or any combination thereof.

  本发明涉及一种血小板添加剂溶液（PAS），该溶液具有一定量的一种或多种β-半乳糖苷酶抑制剂，其中含有或不含有一定量的一种或多种硅糖苷酶抑制剂，以及可选的一种或多种聚糖修饰剂；还有一种或多种 PAS 成分，其中包括盐、柠檬酸源、碳源或它们的任意组合。
• Compartmentalised screening by microfluidic control
  申请人：President and Fellows of Harvard College

  公开号：US10371699B2

  公开（公告）日：2019-08-06

  The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalizing the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.

  本发明描述了一种用于鉴定与生化系统的目标成分结合或调节目标活性的化合物的方法，包括以下步骤：a) 将化合物与目标成分一起分隔到微胶囊中，这样在任何一个微胶囊中都只有一个子集的化合物以多个拷贝的形式存在；b) 鉴定与目标成分结合或调节目标活性的化合物；其中至少有一个步骤是在微流体控制下进行的。本发明可以筛选出大量分子，作为药物开发的线索。
• Ribosomes with tethered subunits
  申请人：Northwestern University

  公开号：US10590456B2

  公开（公告）日：2020-03-17

  An engineered ribosome that includes a tethered subunit arrangement is disclosed, in which the engineered ribosome supports translation of a sequence defined polymer. Methods for making and using the engineered ribosome are also disclosed, including a method for preparing a sequence defined polymer using the engineered ribosome and a method for preparing a sequence defined polymer using the engineered ribosome in a two-protein translation system. The engineered ribosomes may be utilized in methods for incorporating unnatural amino acids into a sequence defined polymer. Also disclosed are optimized polynucleotide sequences for use as tethers and Shine-Dalgarno/anti-Shine-Dalgarno sequences.

  本发明公开了一种包括系链亚基排列的工程核糖体，其中工程核糖体支持序列确定的聚合物的翻译。还公开了制造和使用工程核糖体的方法，包括使用工程核糖体制备定序聚合物的方法和在双蛋白翻译系统中使用工程核糖体制备定序聚合物的方法。工程化核糖体可用于将非天然氨基酸加入序列确定的聚合物的方法中。此外，还公开了用作系链的优化多核苷酸序列和 Shine-Dalgarno/anti-Shine-Dalgarno 序列。