8-amino pentacyclo<5.4.0.0^2,6.0^3,10.0^5,9>undecane | 93779-08-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 8-amino pentacyclo<5.4.0.0^2,6.0^3,10.0^5,9>undecane
• 英文别名: 8-Amino-pentacyclo[5.4.0.02,6.03,10.05,9]undecane；pentacyclo[5.4.0.02,6.03,10.05,9]undecan-8-amine
• CAS: 93779-08-9；136375-86-5
• 化学式: C₁₁H₁₅N
• mdl: MFCD20696306
• 分子量: 161.247
• InChiKey: QJVKRKOJYPDHKU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  五环[5.4.0.02,6.03,10.05,9]十一烷-8-酮 在 sodium hydroxide 、 lithium aluminium tetrahydride 、 盐酸羟胺 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 5.0h， 生成 8-amino pentacyclo<5.4.0.0^2,6.0^3,10.0^5,9>undecane
  参考文献：
  名称：

  Pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines. Synthesis and pharmacology

  摘要：

  The synthesis and biological activity of a series of pentacyclo[5.4.0.0(2,6).0(3.10).0(5.9)]undecyl-8-amino derivatives are described. The activity of the compounds to antagonize the reserpine induced catatonia (anticataleptic) and their ability to reduce the oxotremorine induced tremor and salivation were determined in order to evaluate their potential as anti-Parkinson agents. Promising anticataleptic and mild to weak anticholinergic activities were observed for these compounds. The influence of substituents is discussed.

  DOI：

  10.1016/0223-5234(91)90097-7

文献信息

• Selective reductive dimerization of homocubane series oximes
  作者：V. N. Rodionov、A. S. Sklyarova、T. V. Shamota、P. R. Schreiner、A. A. Fokin

  DOI：10.1134/s1070428011110078

  日期：2011.11

  ketal of the pentacyclo[5.3.0.02,5.03,9.04,8] decan-6-one obtained by the debromination of ethylene ketals of 4,7- and 5,8-dibromopentacyclo[5.3.0.02,5.03,9.04,8] decan-6-one was hydrolyzed to ketone whose oxime was selectively reduced on a platinum catalyst into the di-6-pentacyclo[5.3.0.02,5.03,9.04,8]decylamine. The reaction of reductive dimerization was also characteristic of pentacyclo[4.3.0.02,5

  由1,9-二溴戊酰基氯[5.4.0.0 2,6 .0 3,10 .0 5,9 ] -undeca-8,11-二酮反应，然后水解和环化而制得的二乙烯缩酮和单乙烯缩酮的混合物通过Faworsky方法进行的收缩转化为7-溴五环[5.3.0.0 2,5 .0 3,9 .0 4,8 ] decan-6-one-4-和5-溴五环[5.3.0.0]的乙烯缩酮的混合物2,5 .0 3,9 .0 4,8 ]癸烷-6-一-8-羧酸，其中羧基按照Hunsdiecker-Borodine-Cristol的方法被溴取代。五环的6-乙烯缩酮[5.3.0.0 2,5 .0 3,9 .0 4,8通过将4,7-和5,8-二溴五环[5.3.0.0 2,5 .0 3,9 .0 4,8 ] decan-6-的乙烯酮缩酮脱溴制得的] decan-6-被水解为酮，其肟在铂催化剂上选择性地还原成二-6-五环[5.3.0.0 2,5 .0
• POLYCYCLIC COMPOUNDS FOR USE IN TREATING OCULAR NEURODEGENERATIVE DISEASES
  申请人：Van der Schyf Cornelis J.

  公开号：US20090143457A1

  公开（公告）日：2009-06-04

  Described herein are various compounds for treatment of ocular neurodegenerative diseases, including but not limited to glaucoma and diabetic retinopathy. The compounds described herein can act to attenuate and/or block calcium release from external neuronal environments as well as intracellular stores.
• Pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines. Synthesis and pharmacology
  作者：DW Oliver、TG Dekker、FO Snyckers

  DOI：10.1016/0223-5234(91)90097-7

  日期：1991.6

  The synthesis and biological activity of a series of pentacyclo[5.4.0.0(2,6).0(3.10).0(5.9)]undecyl-8-amino derivatives are described. The activity of the compounds to antagonize the reserpine induced catatonia (anticataleptic) and their ability to reduce the oxotremorine induced tremor and salivation were determined in order to evaluate their potential as anti-Parkinson agents. Promising anticataleptic and mild to weak anticholinergic activities were observed for these compounds. The influence of substituents is discussed.