1-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-5-phenylindoline-2,3-dione | 884496-37-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-5-phenylindoline-2,3-dione
• 英文别名: 5-phenyl-1-[(2R,3R,4S,5R,6R)-3,4,5-tris(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-2-yl]indole-2,3-dione
• CAS: 884496-37-1
• 化学式: C₄₈H₄₃NO₇
• 分子量: 745.872
• InChiKey: ALGVENPSSPWLBD-LBDDKTDWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8
• 重原子数：
  56
• 可旋转键数：
  15
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  83.5
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  1-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-5-phenylindoline-2,3-dione 在 盐酸 、 三溴化硼 、 溶剂黄146 作用下， 以 二氯甲烷 为溶剂， 反应 26.0h， 生成 1-(β-D-glucopyranosyl)-5-phenylisoindigo
  参考文献：
  名称：

  Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

  摘要：

  in the course of structure-activity relationship studies, diversely substituted 1-(beta-(D)-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.10.004
• 作为产物：
  描述：

  5-溴二氢吲哚 在 四(三苯基膦)钯 chromium(VI) oxide 、 四丁基碘化铵 、 sodium hydride 、 sodium carbonate 、 溶剂黄146 、 2,3-二氯-5,6-二氰基-1,4-苯醌 作用下， 以 四氢呋喃 、 1,4-二氧六环 、 乙醇 、 水 、 丙酮 、 甲苯 为溶剂， 反应 83.0h， 生成 1-(2,3,4,6-tetra-O-benzyl-β-D-glucopyranosyl)-5-phenylindoline-2,3-dione
  参考文献：
  名称：

  Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

  摘要：

  in the course of structure-activity relationship studies, diversely substituted 1-(beta-(D)-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies. (c) 2005 Elsevier SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2005.10.004