(2R,3S,4R,5R)-5-(6-amino-8-azidopurin-9-yl)-3,4-dihydroxy-2-(hydroxymethyl)oxolane-2,3-dicarbaldehyde

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: (2R,3S,4R,5R)-5-(6-amino-8-azidopurin-9-yl)-3,4-dihydroxy-2-(hydroxymethyl)oxolane-2,3-dicarbaldehyde
• 化学式: C12H12N8O6
• 分子量: 364.27
• InChiKey: SKXZIELUXFNCQN-PIDJDGCTSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  188
• 氢给体数：
  4
• 氢受体数：
  12

文献信息

• SUPERANTIBODY SYNTHESIS AND USE IN DETECTION, PREVENTION AND TREATMENT OF DISEASE
  申请人：Innexus Biotechnology International Ltd.

  公开号：EP1879616A2

  公开（公告）日：2008-01-23
• Autophilic antibodies and method of making and using same
  申请人：Kohler Heinz

  公开号：US20050287154A1

  公开（公告）日：2005-12-29

  Antibodies having noncovalent, autophilic properties are disclosed. The autophilic antibodies are derived from antibodies conjugated with an autophilic peptide. Such autophilic antibodies can promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Compositions containing the antibodies, and methods of making and using the antibodies are also disclosed.
• AUTOPHILIC ANTIBODIES
  申请人：Kohler Heinz

  公开号：US20090075339A1

  公开（公告）日：2009-03-19

  Autophilic antibodies including an immunoglobulin component and an autophilic peptide fused thereto are provided according to embodiments of the present invention. Particular autophilic antibodies described herein include a chimeric gamma immunoglobulin heavy chain and autophilic peptide expressed as a fusion protein. Preferably the autophilic peptide is expressed at the C-terminus of the immunoglobulin component. Expression vectors according to embodiments of the present invention for use in generating autophilic antibodies are provided which include a first nucleic acid sequence encoding an autophilic peptide, operably linked to a transcription promoter. In particular embodiments, a second nucleic acid sequence encoding a chimeric heavy chain of an immunoglobulin operably linked to the transcription promoter and connected to the first nucleic acid sequence such that expression of the first and second nucleic acid sequences produces a fusion protein of the chimeric heavy chain and the autophilic peptide.
• AUTOPHILIC ANTIBODIES AND METHOD OF MAKING THE SAME
  申请人：Kohler Heinz

  公开号：US20090317379A1

  公开（公告）日：2009-12-24

  Antibodies having noncovalent, autophilic properties are disclosed. The autophilic antibodies are derived from antibodies conjugated with an autophilic peptide. Such autophilic antibodies can promote apoptosis of target cells and enhance therapeutic efficacies in the treatment of patients with diseases or disorders responsive to antibody therapy. Compositions containing the antibodies, and methods of making and using the antibodies are also disclosed.
• US7569674B2
  申请人：——

  公开号：US7569674B2

  公开（公告）日：2009-08-04