9'-amino-10'-fluoro-2',3'-dihydro-8'-oxo-11'-[2-(2-pyridylamino)ethylamino]spiro[cyclopropane-1,4'-[4H,8H]pyrido[1,2,3-ef][1,4]benzoxazepine]-7'-carboxylic acid | 1132813-44-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9'-amino-10'-fluoro-2',3'-dihydro-8'-oxo-11'-[2-(2-pyridylamino)ethylamino]spiro[cyclopropane-1,4'-[4H,8H]pyrido[1,2,3-ef][1,4]benzoxazepine]-7'-carboxylic acid
• 英文别名: 9'-amino-10'-fluoro-2',3'-dihydro-8'-oxo-11'-[2-(2-pyridylamino)ethylamino]spiro[cyclopropane-1,4'-[4H,8H]pyrido[1,2,3-ef][1,5]benzoxazepine]-7'-carboxylic acid；6-Amino-7-fluoro-4-oxo-8-[2-(pyridin-2-ylamino)ethylamino]spiro[10-oxa-1-azatricyclo[7.4.1.05,14]tetradeca-2,5,7,9(14)-tetraene-13,1'-cyclopropane]-3-carboxylic acid
• CAS: 1132813-44-5
• 化学式: C₂₂H₂₂FN₅O₄
• 分子量: 439.446
• InChiKey: NSKUJDMSYBLFMJ-UHFFFAOYSA-N

物化性质

• 熔点：
  237-239 °C
• 沸点：
  776.9±60.0 °C(predicted)
• 密度：
  1.54±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  130
• 氢给体数：
  4
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate 在 硫酸 、 palladium 10% on activated carbon 、 水 、 氢气 、 sodium hydride 、 溶剂黄146 、 potassium nitrate 、 三乙胺 作用下， 以 二甲基亚砜 、 N,N-二甲基甲酰胺 、 甲苯 、 mineral oil 为溶剂， 反应 14.5h， 生成 9'-amino-10'-fluoro-2',3'-dihydro-8'-oxo-11'-[2-(2-pyridylamino)ethylamino]spiro[cyclopropane-1,4'-[4H,8H]pyrido[1,2,3-ef][1,4]benzoxazepine]-7'-carboxylic acid
  参考文献：
  名称：

  Quinolone derivatives containing strained spirocycle as orally active glycogen synthase kinase 3β (GSK-3β) inhibitors for type 2 diabetics

  摘要：

  The design, synthesis, and evaluation of 6-6-7 tricyclic quinolones containing the strained spirocycle moiety aiming at the GSK-3 beta inhibitor were described. Among the synthesized compounds, 44, having a cyclobutane ring on a spirocycle, showed excellent GSK-3b inhibitory activity in both cell-free and cell-based assays (IC50 = 36 nM, EC50 = 3.2 mu M, respectively). Additionally, 44 decreased the plasma glucose concentration dose-dependently after an oral glucose tolerance test in mice. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2011.12.046

文献信息

• [EN] SPIROCYCLIC AMINOQUINOLONES AS GSK-3 INHIBITORS<br/>[FR] AMINOQUINOLONES SPIROCYCLIQUES UTILISÉES EN TANT QU'INHIBITEURS DE GSK-3
  申请人：ACTIVX BIOSCIENCES INC

  公开号：WO2009035684A1

  公开（公告）日：2009-03-19

  Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK- 3 inhibitors mediated diseases. In Formula (I): X1 is O or NR8; A is bond or substituted or unsubstituted C1-C2 alkylene, wherein the substituents when present are selected from one to four Q2 groups; where Q2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2.

  本文提供了化学式I的螺环氨基喹啉类化合物和含有这些化合物的组合物。本文提供的化合物和组合物可用于预防、改善或治疗GSK-3抑制剂介导的疾病。在化学式(I)中：X1为O或NR8；A为键或取代或未取代的C1-C2烷基，其中取代基在存在时来自于一个到四个Q2基团；其中Q2为烷基或卤代烷基；p为0或1；q为0到2的整数。
• SPIROCYCLIC AMINOQUINOLNES AS GSK-3 INHIBITORS
  申请人：Cociorva Oana

  公开号：US20110034436A1

  公开（公告）日：2011-02-10

  Provided herein are spirocyclic aminoquinolones of formula I and compositions containing the compounds. The compounds and compositions provided herein are useful in the prevention, amelioration or treatment of GSK-3 inhibitors mediated diseases. In Formula (I): X 1 is O or NR 8 ; A is bond or substituted or unsubstituted C 1 -C 2 alkylene, wherein the substituents when present are selected from one to four Q 2 groups; where Q 2 is alkyl or haloalkyl; p is 0 or 1; and q is an integer of 0 to 2.

  本文提供了公式I的螺环氨基喹啉酮和含有该化合物的组合物。本文提供的化合物和组合物在预防、改善或治疗GSK-3抑制剂介导的疾病方面具有用途。在公式(I)中：X1为O或NR8；A为键或取代或未取代的C1-C2烷基，其中取代基在存在时从1到4个Q2基中选择；其中Q2为烷基或卤代烷基；p为0或1；q为0到2的整数。
• EP2203459B1
  申请人：——

  公开号：EP2203459B1

  公开（公告）日：2016-03-16
• US8476261B2
  申请人：——

  公开号：US8476261B2

  公开（公告）日：2013-07-02
• US8901112B2
  申请人：——

  公开号：US8901112B2

  公开（公告）日：2014-12-02