3-(p-Bromphenyl)-6-bromcumarin | 16807-65-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 3-(p-Bromphenyl)-6-bromcumarin
• 英文别名: 6-bromo-3-(4-bromo-phenyl)-coumarin；6-Brom-3-(4-brom-phenyl)-cumarin；6-Bromo-3-(4-bromo-phenyl)-chromen-2-one；6-bromo-3-(4-bromophenyl)chromen-2-one
• CAS: 16807-65-1
• 化学式: C₁₅H₈Br₂O₂
• 分子量: 380.035
• InChiKey: GXGLENGJHSKTQN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.9
• 重原子数：
  19
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 吡啶盐酸盐 作用下， 生成 3-(p-Bromphenyl)-6-bromcumarin
  参考文献：
  名称：

  Buu-Hoi et al., Journal of the Chemical Society, 1951, p. 2307

  摘要：

  DOI：

文献信息

• [EN] POLYMERS AND TASK FUNCTIONALIZED POLYMERS FOR ENHANCED CHANGE DETECTION<br/>[FR] POLYMÈRES ET POLYMÈRES FONCTIONNALISÉS POUR UNE TÂCHE POUR LA DÉTECTION AMÉLIORÉE D'UN CHANGEMENT
  申请人：ENVIRONMENTAL TECHNOLOGY SOLUTIONS

  公开号：WO2012135493A1

  公开（公告）日：2012-10-04

  A composition including a polymer covalently bound to at least one molecule, wherein the composition is detectable by exposure to electromagnetic radiation having a wavelength from about 75 nm to about 1000 nm. A method including detecting a disturbance in soil treated with such a composition by distinguishing between a disturbed portion of the treated soil and a non-disturbed portion of the treated soil. The non-disturbed portion of the treated soil emits a greater fluorescence than the disturbed portion of the treated soil.
• Synthesis, Molecular Modeling and Cytotoxicity Study of New 3-Phenyl Coumarin Derivatives against in vitro Cell Lines
  作者：Anuruddha Chabukswar、Prajakta V. Adsule、Swati Jagdale、Dishank V. Purandare、Kunal Raut、Yash Kale

  DOI：10.14233/ajchem.2024.31269

  日期：——

  In pursuit of more effective cancer treatments, researchers embarked on a study to enhance the coumarin derivative’s therapeutic potential. These compounds, known for their anticancer properties, have faced challenges such as increased toxicity and drug resistance. The research aimed to design, synthesize and assess new 3-phenyl coumarin derivatives specifically for breast and lung cancer treatment. Utilizing 3-oxoacyl-reductase (1T8I), a series of compounds were synthesized from aromatic aldehydes and phenylacetic acid. Among the synthesized 11 compounds that were examined, compounds C01, C04, C05 and C08 had significant cytotoxic effects on both MCF-7 and MRC-5 cell lines. Particularly, compound C08, featuring ethoxy and nitrate substitution, exhibited remarkable potential against both cancer cell lines, emphasizing its promise for further exploration in cancer therapy.
• Buu-Hoi et al., Journal of the Chemical Society, 1951, p. 2307
  作者：Buu-Hoi et al.

  DOI：——

  日期：——