Taurodesoxycholsaeure | 516-50-7

• 物质功能分类: 有机原料 - 羧酸类化合物及衍生物
• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: Taurodesoxycholsaeure
• 英文别名: Ethanesulfonic acid, 2-(((3alpha,5beta,12alpha)-3,12-dihydroxy-24-oxocholan-24-yl)amino)-；2-[4-[(3R,5R,8R,9S,10S,12S,13R,14S,17R)-3,12-dihydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoylamino]ethanesulfonic acid
• CAS: 516-50-7；13164-16-4；68780-67-6；68780-71-2；90082-05-6；111187-84-9；130009-01-7；149404-84-2
• 化学式: C₂₆H₄₅NO₆S
• 分子量: 499.712
• InChiKey: AWDRATDZQPNJFN-DLYTVZRCSA-N

物化性质

• 熔点：
  175-200 °C
• 密度：
  1.216±0.06 g/cm3(Predicted)
• 溶解度：
  DMSO（轻微、加热、超声处理）、甲醇（轻微、加热、超声处理）

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  34
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  132
• 氢给体数：
  4
• 氢受体数：
  6

制备方法与用途

生物用途

牛磺异熊去氧胆酸通过激活EGFR依赖性的PI3K/Akt信号传导，使人体结肠癌细胞免于凋亡。

文献信息

• Sweetness enhancer, sweetener compositions, and consumables containing the same
  申请人：Nutrinova Nutrition Specialties & Food Ingredients GmbH

  公开号：EP2606747A1

  公开（公告）日：2013-06-26

  The present invention relates to the use of deoxycholic acid or a derivative or a stereoisomer or a salt or a hydrate thereof as a sweetness enhancer, to sweetener compositions comprising a sweetener and deoxycholic acid or a derivative or a stereoisomer or a salt or a hydrate thereof, to methods of making the sweetener compositions and to tabletop sweetener compositions comprising deoxycholic acid or a derivative or a stereoisomer or a salt or a hydrate thereof. Further, the invention relates to consumables comprising a consumable product and deoxycholic acid or a derivative or a stereoisomer or a salt or a hydrate thereof. Preferred consumable products are water-based consumables, solid dry consumables, dairy products, dairy-derived products and dairy-alternative products.

  本发明涉及脱氧胆酸或其衍生物或其立体异构体或其盐或其水合物作为甜味增强剂的用途，涉及包含甜味剂和脱氧胆酸或其衍生物或其立体异构体或其盐或其水合物的甜味剂组合物，涉及甜味剂组合物的制造方法，还涉及包含脱氧胆酸或其衍生物或其立体异构体或其盐或其水合物的片剂甜味剂组合物。此外，本发明还涉及由消费品和脱氧胆酸或其衍生物或其立体异构体或其盐或其水合物组成的消费品。优选的耗材为水基耗材、固体干燥耗材、乳制品、乳制品衍生产品和乳制品替代产品。
• METHOD FOR DETERMININGIN VITRO
  申请人：Clayton Pharmaceuticals LLC

  公开号：EP3423829A1

  公开（公告）日：2019-01-09
• METHOD FOR DETERMINING IN VITRO BIOEQUIVALENCE OF A SUCRALFATE SUSPENSION SAMPLE TO A SUCRALFATE SUSPENSION REFERENCE LISTED DRUG (RLD)
  申请人：Clayton Pharmaceuticals LLC

  公开号：EP3423829B1

  公开（公告）日：2020-10-28
• ANTIMICROBIAL MATERIALS INCLUDING EXCHANGED AND INFUSED ANTIMICROBIAL AGENTS
  申请人：CORNING INCORPORATED

  公开号：US20190106354A1

  公开（公告）日：2019-04-11

  Embodiments of antimicrobial materials are provided. In one or more embodiments, the antimicrobial materials include an inorganic substrate including a surface portion surrounding an internal portion and an antimicrobial agent disposed on any one or more of the surface portion and the internal portion. In some embodiments, the inorganic substrate included alkali and at least a portion of the alkali is present on the surface portion. In another embodiment the antimicrobial agent is infused into the substrate. In some instances, non-alkali components present in the substrate are replaced with the antimicrobial agent. In some embodiments, anions in the substrate are replaced with the antimicrobial agent. Compositions including the antimicrobial materials are disclosed and methods for making the antimicrobial materials and compositions are also provided.
• US9989519B1
  申请人：——

  公开号：US9989519B1

  公开（公告）日：2018-06-05