1-Oxo-7-isopropyl-10-methyl-decalin | 22451-64-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1-Oxo-7-isopropyl-10-methyl-decalin
• 英文别名: (4aS,7R,8aR)-4a-methyl-7-propan-2-yl-2,3,4,5,6,7,8,8a-octahydronaphthalen-1-one
• CAS: 22451-64-5
• 化学式: C₁₄H₂₄O
• 分子量: 208.344
• InChiKey: CXNWHAFRKIGDKO-DYEKYZERSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.93
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  丁硫醇 、 1-Oxo-7-isopropyl-10-methyl-decalin 、 甲酸乙酯 生成 2-Butylmercaptomethylen-1-oxo-7-isopropyl-10-methyl-decalin
  参考文献：
  名称：

  Govindachari,T.R. et al., Indian Journal of Chemistry, 1968, vol. 6, p. 475 - 481

  摘要：

  DOI：
• 作为产物：
  描述：

  (+)-二氢香芹酮 在 palladium on activated charcoal 盐酸 、 lithium aluminium tetrahydride 、 potassium tert-butylate 、 氨 、 氢气 、 calcium 、 四乙基对甲苯磺酸铵 、 对甲苯磺酸 、 三乙胺 作用下， 以 四氢呋喃 、 乙醚 、 二氯甲烷 、 乙酸乙酯 、 N,N-二甲基甲酰胺 、 异丙醇 、 叔丁醇 、 苯 为溶剂， 60.0 ℃ 、101.33 kPa 条件下， 反应 13.75h， 生成 1-Oxo-7-isopropyl-10-methyl-decalin
  参考文献：
  名称：

  Electroorganic chemistry. 140. Electroreductively promoted intra- and intermolecular couplings of ketones with nitriles.

  摘要：

  Electroreduction of gamma and delta-cyano ketones in i-PrOH with Sn cathode gave alpha-hydroxy ketones and their dehydroxylated ketones as the intramolecularly coupled products. Guaiazulene, (-)-valeranone, polyquinanes, dihydrojasmone, methyl dihydrojasmonate, and rosaprostol have been synthesized by utilizing this electroreductive intramolecular coupling of gamma and delta-cyano ketones in one of the key steps. Similarly, electroreduction of a mixture of ketone and nitrile gave the corresponding intermolecularly coupled product. The product obtained by the electroreductive intermolecular coupling of (+)-dihydrocarvone with acetonitrile has been found to be the precursor of an effective chiral ligand for the enantioselective addition of diethylzinc to aldehydes.

  DOI：

  10.1021/jo00052a036

文献信息

• Electroorganic chemistry. 140. Electroreductively promoted intra- and intermolecular couplings of ketones with nitriles.
  作者：Tatsuya Shono、Naoki Kise、Taku Fujimoto、Naoto Tominaga、Hiroshi Morita

  DOI：10.1021/jo00052a036

  日期：1992.12

  Electroreduction of gamma and delta-cyano ketones in i-PrOH with Sn cathode gave alpha-hydroxy ketones and their dehydroxylated ketones as the intramolecularly coupled products. Guaiazulene, (-)-valeranone, polyquinanes, dihydrojasmone, methyl dihydrojasmonate, and rosaprostol have been synthesized by utilizing this electroreductive intramolecular coupling of gamma and delta-cyano ketones in one of the key steps. Similarly, electroreduction of a mixture of ketone and nitrile gave the corresponding intermolecularly coupled product. The product obtained by the electroreductive intermolecular coupling of (+)-dihydrocarvone with acetonitrile has been found to be the precursor of an effective chiral ligand for the enantioselective addition of diethylzinc to aldehydes.
• Govindachari,T.R. et al., Indian Journal of Chemistry, 1968, vol. 6, p. 475 - 481
  作者：Govindachari,T.R. et al.

  DOI：——

  日期：——