10-Deoxy-7,8-dihydro-genipin | 196509-97-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 10-Deoxy-7,8-dihydro-genipin
• 英文别名: Methyl (4aS, 7R, 7aR)-1,4a,5,6,7,7a-hexahydro-1-hydroxy-7-methylcyclopenta[c]pyran-4-carboxylate；methyl (4aS,7R,7aR)-1-hydroxy-7-methyl-1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylate
• CAS: 196509-97-4
• 化学式: C₁₁H₁₆O₄
• 分子量: 212.246
• InChiKey: GGFAHFSRIITJIJ-NGHWHVEGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  10-Deoxy-7,8-dihydro-genipin 生成 3(R)-cis,cis-boschnialinic acid
  参考文献：
  名称：

  Terpenoids. XLVII.¹ The Structure of Genipin²

  摘要：

  DOI：

  10.1021/jo01063a052
• 作为产物：
  描述：

  genipin 在 铂 氢气 作用下， 以 溶剂黄146 为溶剂， 生成 10-Deoxy-7,8-dihydro-genipin
  参考文献：
  名称：

  Terpenoids. XLVII.¹ The Structure of Genipin²

  摘要：

  DOI：

  10.1021/jo01063a052

文献信息

• Iridoid derivatives and the use thereof as a drug
  申请人：Tsumura & Co.

  公开号：US05459160A1

  公开（公告）日：1995-10-17

  Iridoid derivatives synthesized using genipin, which is an aglycon of geniposide, as the starting material are useful as an anti-hyperlipemia agent and as a cholagogue.

  使用玄参苷的无糖基物质——玄参苷酚作为起始材料合成的萜类衍生物可用作抗高脂血症剂和胆汁催泻剂。
• Compositions and methods for treatment of liver disease
  申请人：Fong Harry

  公开号：US20080319042A1

  公开（公告）日：2008-12-25

  The present invention comprises compositions and methods for the treatment of liver disease, particularly treatments for infection by HCV and/or HBV. The present invention comprises antiviral compositions comprising lamiridosin, derivatives of lamiridosin or iridoids that are effective in inhibiting one or more steps in the infection of cells by HCV or HBV. Methods for treating subjects, particularly humans, infected with HCV or HBV are provided.
• Terpenoids. XLVII.¹ The Structure of Genipin²
  作者：CARL DJERASSI、T. NAKANO、A. N. JAMES、L. H. ZALKOW、E. J. EISENBRAUN、J. N. SHOOLERY

  DOI：10.1021/jo01063a052

  日期：1961.4