D-Lactose monohydrate | 64044-51-5

• 物质功能分类: 生物化工 - 糖类化合物 - 双糖
• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: D-Lactose monohydrate
• 英文别名: 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol;hydrate
• CAS: 64044-51-5；5989-81-1；10039-26-6
• 化学式: C12H24O12
• 分子量: 360.31
• InChiKey: WSVLPVUVIUVCRA-UHFFFAOYSA-N

物化性质

• 熔点：
  219 °C
• 比旋光度：
  [α]D20+52.2～+52.8°
• 沸点：
  412.35°C (rough estimate)
• 密度：
  1,53 g/cm3
• 溶解度：
  H2O：可溶1M，透明，无色

计算性质

• 辛醇/水分配系数(LogP)：
  -6.22
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  191
• 氢给体数：
  9
• 氢受体数：
  12

安全信息

• TSCA：
  Yes
• 危险品标志：
  Xi
• 安全说明：
  S26,S36
• 危险类别码：
  R36/37/38
• WGK Germany：
  3
• 海关编码：
  17021900
• 危险品运输编号：
  NONH for all modes of transport
• RTECS号：
  OD9625000

制备方法与用途

概述

蔗糖是食糖的主要成分，属于一种双糖，由一分子葡萄糖与一分子果糖缩合脱水而成。在甘蔗、甜菜及槭树汁中含量丰富。蔗糖味道甜美，是重要的食品和甜味调味品。

生理作用

α-乳糖水合物在胃中不易被消化，可直接到达肠道，在空回肠内易被乳糖酶分解为葡萄糖和半乳糖。葡萄糖主要提供能量，而半乳糖促进脑苷和黏多糖类的生成，参与大脑发育，对婴儿智力发育尤为重要。此外，α-乳糖水合物还能促进某些乳酸菌的生长，抑制腐败菌的繁殖。

制法

蔗糖的主要原料是甘蔗（Saccharum spp.）和甜菜（Beta vulgaris）。将甘蔗或甜菜压碎提取糖汁，过滤后用石灰处理以去除杂质并漂白；随后煮沸糖汁，除去底部沉淀物和表面泡沫，待其冷却结晶成为蔗糖。

用途

蔗糖用于分析试剂、色谱分析及生物培养基的制备。此外，它还用作色谱吸附剂和细菌培养基。α-乳糖在常温水溶液中结晶形成α-乳糖，在93℃以上则变成β-乳糖。α-乳糖呈单斜晶体结构，具有微弱甜味，通常带有结晶水；120℃时失去结晶水，并且其水溶液在加热过程中会发生变旋现象。β-乳糖比α-乳糖稍甜，熔点为252℃，同样具有变旋性质。

文献信息

• Glycosylated beta-galactosidase compositions having improved transgalactosylating activity
  申请人：Novozymes A/S

  公开号：US11304425B2

  公开（公告）日：2022-04-19

  The present invention relates to compositions, particularly liquid compositions, comprising polypeptides having beta-galactosidase activity, methods of making said compositions, and uses of the compositions for making e.g. dairy products. The polypeptides having beta-galactosidase activity are modified by glycation of lysine and/or arginine residues by incubating the enzyme in the presence of reducing sugars, optionally combined with a heat treatment. Thereby, transgalactosylating activity is increased.

  本发明涉及包含具有β-半乳糖苷酶活性的多肽的组合物，特别是液体组合物，制造所述组合物的方法，以及组合物在制造乳制品等方面的用途。具有β-半乳糖苷酶活性的多肽通过赖氨酸和/或精氨酸残基的糖化进行修饰，方法是将酶在还原糖存在下孵育，可选择结合热处理。这样，转半乳糖苷酶的活性就会提高。
• METHOD FOR REDUCING LACTOSE AT HIGH TEMPERATURES
  申请人：DuPont Nutrition Biosciences ApS

  公开号：EP3930469A1

  公开（公告）日：2022-01-05
• COSMETIC AND PHARMACEUTICAL AGENTS FOR TREATING WOUNDS AND/OR HEMORRHAGING OF THE SKIN, MUCOUS MEMBRANES OR THE GUM, IN PARTICULAR, FOR EXAMPLE, SUPERFICIAL CRACKS (RHAGADES) OR PERIODONTITIS
  申请人：Bogaert Jean-Pierre

  公开号：US20170326237A1

  公开（公告）日：2017-11-16

  The invention relates to an agent, in particular a cosmetic and/or pharmaceutical agent, containing an active composition and optionally an adhesion composition, said active composition containing at least one organic or inorganic chlorine compound and at least one oxidation agent, for use in the treatment of wounds and/or hemorrhaging of the skin, mucous membranes or the gums, in particular in the absence of canker sores.
• Milk Products Comprising High Amounts of Galactooligosaccharides (GOS) and Their Production
  申请人：Novozymes A/S

  公开号：US20200113200A1

  公开（公告）日：2020-04-16

  The present invention relates to milk products comprising a high amount of in situ produced galactooligosaccharides (GOS) and methods of producing same. Milk substrate having a lactose content of at least 20 wt % lactose is treated with an enzyme having transgalactosylating activity. The transgalactosylating activity of said enzyme may have been increased via glycation of lysine and/or arginine residues by incubation of said enzyme with high concentrations of glucose at elevated temperatures.
• Glycosylated Beta-Galactosidase Compositions Having improved Transgalactosylating Activity
  申请人：Novozymes A/S

  公开号：US20200232004A1

  公开（公告）日：2020-07-23

  The present invention relates to compositions, particularly liquid compositions, comprising polypeptides having beta-galactosidase activity, methods of making said compositions, and uses of the compositions for making e.g. dairy products. The polypeptides having beta-galactosidase activity are modified by glycation of lysine and/or arginine residues by incubating the enzyme in the presence of reducing sugars, optionally combined with a heat treatment. Thereby, transgalactosylating activity is increased.