Boc-L-2,4-二甲基苯丙氨酸 | 849440-31-9

• 物质功能分类: 生物化工 - 氨基酸及其衍生物 - 丙氨酸类衍生物
• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: Boc-L-2,4-二甲基苯丙氨酸
• 中文别名: BOC-L-2,4-二甲基苯丙氨酸
• 英文名称: N-Boc-(S)-2',4'-dimethylphenylalanine
• 英文别名: Boc-L-2,4-dimethylphenylalanine；(2S)-3-(2,4-dimethylphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid
• CAS: 849440-31-9
• 化学式: C₁₆H₂₃NO₄
• 分子量: 293.363
• InChiKey: AVJPLTQARRYWFZ-ZDUSSCGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  二碳酸二叔丁酯 、 2,4-二甲基苄基溴 、 nickelous 2-[(E)-[[2-[(2S)-1-benzylpyrrolidine-2-carbonyl]azanidylphenyl]-phenylmethylene]amino]acetate 在 sodium hydroxide 、 盐酸 、 sodium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 甲醇 、 1,4-二氧六环 、 水 为溶剂， 生成 Boc-L-2,4-二甲基苯丙氨酸 、 (R)-2- [N-(N-苄基脯氨酰）氨基]二苯甲酮
  参考文献：
  名称：

  Asymmetric Synthesis of All Six Regioisomers of N-Boc-dimethyl-phenylalanines

  摘要：

  DOI：

  10.3987/com-04-s(p)41

文献信息

• MELANOCORTIN RECEPTOR-SPECIFIC PIPERAZINE COMPOUNDS WITH DIAMINE GROUPS
  申请人：Palatin Technologies, Inc.

  公开号：EP1922072A2

  公开（公告）日：2008-05-21
• MELANOCORTIN RECEPTOR-SPECIFIC PIPERAZINE AND KETO-PIPERAZINE COMPOUNDS
  申请人：Palatin Technologies, Inc.

  公开号：EP1919479A2

  公开（公告）日：2008-05-14
• Melanocortin Receptor-Specific Piperazine and Keto-Piperazine Compounds
  申请人：SHARMA D. Shubh

  公开号：US20060287332A1

  公开（公告）日：2006-12-21

  Melanocortin receptor-specific compounds of the general formula and pharmaceutically acceptable salts thereof, where X, W, J, Q, L 1 , L 2 , L 3 , R 1a , R 1b , R 2a , and R 2b are as defined in the specification, and the carbon atom marked with an asterisk can have any stereochemical configuration. Compounds disclosed herein bind to one or more melanocortin receptors and may be an agonist, a partial agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist as to one or more melanocortin receptors, and may be employed for treatment of one or more melanocortin receptor-associated conditions or disorders, including specifically treatment of obesity and related conditions.
• Substituted Melanocortin Receptor-Specific Single Acyl Piperazine Compounds
  申请人：SHARMA D. Shubh

  公开号：US20060287330A1

  公开（公告）日：2006-12-21

  Melanocortin receptor-specific compounds of the general formula and pharmaceutically acceptable salts thereof, where J is a substituted or unsubstituted monocyclic or bicyclic ring structure, W is a heteroatom unit with at least one cationic center, hydrogen bond donor or hydrogen bond acceptor, Q is a substituted or unsubstituted aromatic carbocyclic ring group, L, R 2a , R 2b , R 3a , R 3b , r, x and y are as defined in the specification, and the carbon atoms marked with an asterisk can have any stereochemical configuration. Compounds disclosed herein bind to one or more melanocortin receptors and may be an agonist, a partial agonist, an antagonist, an inverse agonist or an antagonist of an inverse agonist as to one or more melanocortin receptors, and may be employed for treatment of one or more melanocortin receptor-associated conditions or disorders, including specifically treatment of obesity and related conditions.
• Diamine-Containing, Tetra-Substituted Piperazine Compounds Having Identical 1- and 4-Substituents
  申请人：Burris Kevin

  公开号：US20080070921A1

  公开（公告）日：2008-03-20

  There is provided compounds having the formula of structure I: wherein the groups —C(R 8 )(CH 2 ) v CH(R 9 )(CH 2 ) y -Q and —C(R 8 )(CH 2 ) v CH(R 9 )(CH 2 ) y -J are the same, and R 1a , R 1b , R 2a , R 2b , R 8 , R 9 , J, Q, W, X, L 2 , v and y have meanings given in the description. Thus use of such compounds in the treatment of a condition responsive to changes in melanocortin receptor function in a human or non-human mammal (e.g. male sexual dysfunction, female sexual dysfunction, an eating disorder, above optimal body weight, obesity, below-optimal body weight or cachexia) is also described.