(3R)-Claussequinone | 35878-39-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: (3R)-Claussequinone
• 英文别名: 2-[(3R)-7-hydroxy-3,4-dihydro-2H-chromen-3-yl]-5-methoxycyclohexa-2,5-diene-1,4-dione
• CAS: 35878-39-8
• 化学式: C₁₆H₁₄O₅
• 分子量: 286.28
• InChiKey: PDAKXMIQFUHWQC-JTQLQIEISA-N

物化性质

• 沸点：
  490.2±45.0 °C(Predicted)
• 密度：
  1.38±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  (3R)-Claussequinone 生成 [(3R)-3-(4-methoxy-3,6-dioxocyclohexa-1,4-dien-1-yl)-3,4-dihydro-2H-chromen-7-yl] acetate
  参考文献：
  名称：

  YAHARA, SHOJI;OGATA, TETSU;SAIJO, REIKO;KONISHI, RYOJI;YAMAHARA, JOHJI;MI+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 979-987

  摘要：

  DOI：

文献信息

• YAHARA, SHOJI;OGATA, TETSU;SAIJO, REIKO;KONISHI, RYOJI;YAMAHARA, JOHJI;MI+, CHEM. AND PHARM. BULL., 37,(1989) N, C. 979-987
  作者：YAHARA, SHOJI、OGATA, TETSU、SAIJO, REIKO、KONISHI, RYOJI、YAMAHARA, JOHJI、MI+

  DOI：——

  日期：——
• COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS
  申请人：The Hospital For Sick Children

  公开号：EP2598150A2

  公开（公告）日：2013-06-05
• Extracts of Cranberry and Methods of Using Thereof
  申请人：Alberte Randall S.

  公开号：US20100028469A1

  公开（公告）日：2010-02-04

  The present disclosure relates in part to extracts of cranberry ( Vaccinium macrocarpon ) comprising an enriched amount of certain compounds having anti-infective activity, e.g. antibacterial and/or antifungal activity, e.g. activity against C. albicans . Another aspect of the disclosure relates to combined cranberry and cinnamon extracts. In certain embodiments, these combined extracts have been optimized to control urinary tract infections caused by E. coli, S. aureus and C. albicans . Certain embodiments of the extract are enriched in bioactive compounds that have been shown to inhibit C. albicans adhesion and/or biofilm formation and its growth in vitro. In another aspect of the disclosure, the extracts are enriched in bioactives derived from cranberry and cinnamon that have been shown to inhibit the attachment and the growth of common urinary tract pathogens like E. coli, S. aureus and C. albicans.
• US8748177B2
  申请人：——

  公开号：US8748177B2

  公开（公告）日：2014-06-10
• [EN] COMPOSITIONS FOR PROLIFERATION OF CELLS AND RELATED METHODS<br/>[FR] COMPOSITIONS POUR LA PROLIFÉRATION DE CELLULES ET PROCÉDÉS ASSOCIÉS
  申请人：HOSPITAL FOR SICK CHILDREN

  公开号：WO2010039679A1

  公开（公告）日：2010-04-08

  We have discovered that p63 inhibition results in increased cellular proliferation. We have also performed a screen for agents capable of increasing cellular proliferation, (e.g., of stem cells such as skin-derived precursors (SKPs)). The invention therefore invention provides compositions, methods, and kits for increasing proliferation of cells, using compounds that decrease p63 expression or activity or using the compounds described herein. The invention also features methods of using these compounds for increasing hair growth, improving skin health, or promoting skin repair in a subject.