5',9'-Dibromospiro[1,3-dioxolane-2,10'-pentacyclo[5.3.0.02,5.03,9.04,8]decane]-6'-one | 25867-84-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 5',9'-Dibromospiro[1,3-dioxolane-2,10'-pentacyclo[5.3.0.02,5.03,9.04,8]decane]-6'-one
• CAS: 25867-84-9
• 化学式: C₁₂H₁₀Br₂O₃
• 分子量: 362.018
• InChiKey: GABJUTVSUROVBC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  17
• 可旋转键数：
  0
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  5',9'-Dibromospiro[1,3-dioxolane-2,10'-pentacyclo[5.3.0.02,5.03,9.04,8]decane]-6'-one 在 二氯甲烷 、 magnesium sulfate 、 正戊烷 作用下， 以 氢氧化钾 为溶剂， 反应 16.0h， 以yields (33), mp 154°-155° C.的产率得到1-立方烷羧酸
  参考文献：
  名称：

  Initiation and bonding of diamond and other thin films

  摘要：

  一种在基底上形成薄膜的方法。该方法包括以下步骤：在基底上形成自组装单分子层薄膜，其中单分子层的一端与基底结合，另一端形成一个能够启动所需薄膜形成的表面。该发明的首选方法涉及在基底上形成金刚石层。

  公开号：

  US05455072A1
• 作为产物：
  描述：

  2,7-Dibrom-8,8-ethylendioxy-3-oxo-3a,4,7,7a-tetrahydro-4,7-methano-inden 以98%的产率得到5',9'-Dibromospiro[1,3-dioxolane-2,10'-pentacyclo[5.3.0.02,5.03,9.04,8]decane]-6'-one
  参考文献：
  名称：

  Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists

  摘要：

  Computational modeling demonstrates that the van-der-Waals surfaces of homocubyl amines are similar to that of the neuroprotector Memantine (R). Utilizing readily available precursors we report the preparation of a series of homological cubylamines, namely pentacyclo[6.3.0.0(2,6).0(3,10).0(5,9)]undecyl-4-amine (trishomocubyl-4-amine, 2), pentacyclo[5.3.0.0(2,5). 0(3,9).0(4,8)]decyl-10-amine (bishomocubyl-10-amine, 3), pentacyclo[4.3.0.0(2,5).0(3,8).0(4,7)]nonyl-9-amine (homocubyl-9-amine, 4), and pentacyclo[4.2.0.0(2,5).0(3,8).0(4,7)]octyl-1-amine (cubylamine, 5). The hydrochlorides of amines 2-5 show pronounced affinity for the (+) MK-801 channel binding site, and it seems likely that these compounds would act as very fast voltage-dependent NMDA receptor antagonists.

  DOI：

  10.1007/s00044-012-0029-7

文献信息

• Synthesis of functionalized basketanes by a regiospecific cage expansion of homocubanones
  作者：A.J.C. Van Seters、M. Buza、A.J.H. Klunder、B. Zwanenburg

  DOI：10.1016/s0040-4020(01)97680-x

  日期：1981.1
• AGADZHANYAN TS. E.; MAVSESYAN R. A.; KAZARYAN R. K.; CHASOYAN A. A.; SAMV+, AJKAKAN KIMIAKAN AMSAGIR, ARM. XIM. ZH., 1981, 34, HO 2, 159-162,
  作者：AGADZHANYAN TS. E.、 MAVSESYAN R. A.、 KAZARYAN R. K.、 CHASOYAN A. A.、 SAMV+

  DOI：——

  日期：——
• Preparation and testing of homocubyl amines as therapeutic NMDA receptor antagonists
  作者：Anna S. Sklyarova、Vladimir N. Rodionov、Christopher G. Parsons、Günter Quack、Peter R. Schreiner、Andrey A. Fokin

  DOI：10.1007/s00044-012-0029-7

  日期：2013.1

  Computational modeling demonstrates that the van-der-Waals surfaces of homocubyl amines are similar to that of the neuroprotector Memantine (R). Utilizing readily available precursors we report the preparation of a series of homological cubylamines, namely pentacyclo[6.3.0.0(2,6).0(3,10).0(5,9)]undecyl-4-amine (trishomocubyl-4-amine, 2), pentacyclo[5.3.0.0(2,5). 0(3,9).0(4,8)]decyl-10-amine (bishomocubyl-10-amine, 3), pentacyclo[4.3.0.0(2,5).0(3,8).0(4,7)]nonyl-9-amine (homocubyl-9-amine, 4), and pentacyclo[4.2.0.0(2,5).0(3,8).0(4,7)]octyl-1-amine (cubylamine, 5). The hydrochlorides of amines 2-5 show pronounced affinity for the (+) MK-801 channel binding site, and it seems likely that these compounds would act as very fast voltage-dependent NMDA receptor antagonists.
• Initiation and bonding of diamond and other thin films
  申请人：——

  公开号：US05455072A1

  公开（公告）日：1995-10-03

  A method for forming thin films on substrates. The method includes the steps of forming a self-assembled monolayer film on a substrate where one end of the monolayer bonds to the substrate and the other end forms a surface capable of initiating the formation of a desired film. A preferred method of the invention involves formation of diamond layers over substrates.

  一种在基底上形成薄膜的方法。该方法包括以下步骤：在基底上形成自组装单分子层薄膜，其中单分子层的一端与基底结合，另一端形成一个能够启动所需薄膜形成的表面。该发明的首选方法涉及在基底上形成金刚石层。