2-[(2-fluorophenyl)(1H-indol-3-yl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-enone | 537010-96-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• 英文名称: 2-[(2-fluorophenyl)(1H-indol-3-yl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-enone
• 英文别名: 2-[(2-fluorophenyl)-(1H-indol-3-yl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-en-1-one
• CAS: 537010-96-1
• 化学式: C₂₃H₂₂FNO₂
• 分子量: 363.432
• InChiKey: NEKUQZJASLOKOJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  吲哚 、 5,5-二甲基-1,3-环己二酮 、 2-氟苯甲醛 在 L-脯氨酸 作用下， 以 乙醇 为溶剂， 反应 0.33h， 以90%的产率得到2-[(2-fluorophenyl)(1H-indol-3-yl)methyl]-3-hydroxy-5,5-dimethylcyclohex-2-enone
  参考文献：
  名称：

  芳香醛与两种不同亲核试剂的三组分反应及其离解能力的下游转化率决定

  摘要：

  AbstractMany three‐component reactions of aromatic aldehydes with activated methylene derivatives and an associated nucleophile have been developed by using L‐proline as the catalyst. Nucleophiles, such as indoles, thiophenols, mercaptans, 2‐methylfuran and benzenesulfinic acid, could be successfully used in the reactions while the activated methylene derivatives can be 1,3‐cyclohexanedione, dimedone, 1,3‐cyclopentanedione, 1‐phenyl‐3‐methyl‐5‐pyrazolone, 4‐hydroxycoumarin, 4,6‐dihydroxy‐2‐mercaptopyrimidine, 4‐hydroxy‐1‐methyl‐2quinolone, 4‐hydroxy‐6‐methyl‐2‐pyrone and 2‐hydroxy‐1,4‐naphthoquinone. Investigation of the downstream utilization of the products from the above multicomponent reactions (MCRs) revealed that selective cleavages of carbon‐carbon and carbon‐heteroatom bonds in these molecules are indeed possible, which opens an avenue to access some new SN1‐type reactions. Particularly, when the MCR product of an aromatic aldehyde, dimedone and thiophenol was treated with an acid catalyst in the presence of an appropriate nucleophile, cleavage of the carbon‐sulfur bond occurred preferentially, thus providing many complex molecules that cannot be attained by other known methods.magnified image

  DOI：

  10.1002/adsc.201300790

文献信息

• Three-Component Reactions of Aromatic Aldehydes and Two Different Nucleophiles and their Leaving Ability-Determined Downstream Conversions of the Products
  作者：Minghao Li、Amir Taheri、Meng Liu、Shaohuan Sun、Yanlong Gu

  DOI：10.1002/adsc.201300790

  日期：2014.2.10

  AbstractMany three‐component reactions of aromatic aldehydes with activated methylene derivatives and an associated nucleophile have been developed by using L‐proline as the catalyst. Nucleophiles, such as indoles, thiophenols, mercaptans, 2‐methylfuran and benzenesulfinic acid, could be successfully used in the reactions while the activated methylene derivatives can be 1,3‐cyclohexanedione, dimedone, 1,3‐cyclopentanedione, 1‐phenyl‐3‐methyl‐5‐pyrazolone, 4‐hydroxycoumarin, 4,6‐dihydroxy‐2‐mercaptopyrimidine, 4‐hydroxy‐1‐methyl‐2quinolone, 4‐hydroxy‐6‐methyl‐2‐pyrone and 2‐hydroxy‐1,4‐naphthoquinone. Investigation of the downstream utilization of the products from the above multicomponent reactions (MCRs) revealed that selective cleavages of carbon‐carbon and carbon‐heteroatom bonds in these molecules are indeed possible, which opens an avenue to access some new SN1‐type reactions. Particularly, when the MCR product of an aromatic aldehyde, dimedone and thiophenol was treated with an acid catalyst in the presence of an appropriate nucleophile, cleavage of the carbon‐sulfur bond occurred preferentially, thus providing many complex molecules that cannot be attained by other known methods.magnified image