9-(4-((3-(4-nitrophenyl)-3H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-10-(4-nitrophenyl)acridine-1,8(2H,5H,9H,10H)-dione | 1397291-73-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 9-(4-((3-(4-nitrophenyl)-3H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-10-(4-nitrophenyl)acridine-1,8(2H,5H,9H,10H)-dione
• 英文别名: 3,3,6,6-tetramethyl-10-(4-nitrophenyl)-9-[4-[[1-(4-nitrophenyl)triazol-4-yl]methoxy]phenyl]-4,5,7,9-tetrahydro-2H-acridine-1,8-dione
• CAS: 1397291-73-4
• 化学式: C₃₈H₃₆N₆O₇
• 分子量: 688.74
• InChiKey: AKIBRQMTMOVFQS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.3
• 重原子数：
  51
• 可旋转键数：
  6
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  169
• 氢给体数：
  0
• 氢受体数：
  10

反应信息

• 作为产物：
  描述：

  4-nitrophenyl azide 、 4-(丙-2-炔-1-基氧基)苯甲醛 、 5,5-二甲基-1,3-环己二酮 、 4-硝基苯胺 在 copper diacetate 、 sodium ascorbate 、 N-methylimidazolium trifluoroacetate 作用下， 以 乙醇 、 水 为溶剂， 反应 6.0h， 以83%的产率得到9-(4-((3-(4-nitrophenyl)-3H-1,2,3-triazol-4-yl)methoxy)phenyl)-3,4,6,7-tetrahydro-3,3,6,6-tetramethyl-10-(4-nitrophenyl)acridine-1,8(2H,5H,9H,10H)-dione
  参考文献：
  名称：

  Facile and Highly Efficient Procedure for the Synthesis of Triazolyl Methoxyphenyl 1,8-Dioxo-decahydroacridines via One-Pot, Pseudo-Five-Component Reaction

  摘要：

  A series of triazolyl methoxyphenyl 1,8-dioxo-decahydroacridine derivatives has been prepared in a one-pot, pseudo-five-component reaction of aromatic propargylated aldehydes, various azides, dimedone, and a variety of amines in the presence of Cu(OAc)(2)/sodium ascorbate and 1-methylimidazolium trifluoroacetate ([Hmim]TFA) as the catalyst in good yields.

  DOI：

  10.1080/00397911.2011.577263

文献信息

• Facile and Highly Efficient Procedure for the Synthesis of Triazolyl Methoxyphenyl 1,8-Dioxo-decahydroacridines via One-Pot, Pseudo-Five-Component Reaction
  作者：Minoo Dabiri、Peyman Salehi、Mahboobeh Bahramnejad、Fatemeh Sherafat、Morteza Bararjanian

  DOI：10.1080/00397911.2011.577263

  日期：2012.11

  A series of triazolyl methoxyphenyl 1,8-dioxo-decahydroacridine derivatives has been prepared in a one-pot, pseudo-five-component reaction of aromatic propargylated aldehydes, various azides, dimedone, and a variety of amines in the presence of Cu(OAc)(2)/sodium ascorbate and 1-methylimidazolium trifluoroacetate ([Hmim]TFA) as the catalyst in good yields.