申请人：——
公开号：US20020170125A1
公开（公告）日：2002-11-21
The new diaminopyrazole compounds are bridged 4,5-diaminopyrazole compounds or salts thereof. These diaminopyrazole compounds have the formula (I):
1
wherein R1 represents hydrogen, a C
1
- to C
6
-alkyl, a C
1
- to C
4
-hydroxyalkyl, a C
1
- to C
4
-aminoalkyl, a C
1
- to C
8
-alkylamino, a di(C
1
- to C
8
-alkyl)amino, a C
1
- to C
4
-alkylamino-(C
1
- to C
4
-alkyl), a di(C
1
- to C
4
-alkylamino)-C
1
- to C
4
-alkyl, an aryl or a heteroaryl; R2 and R3 each represent hydrogen, a straight-chain or branched C
1
- to C
6
-alkyl, an aryl, a heteroaryl, a carboxylic acid, a carboxylic acid ester, an unsubstituted or substituted carboxylic acid amide, a hydroxy or a C
1
- to C
4
-hydroxyalkyl group, or R2 and R3 together represent a C
1
- to C
6
-alkylene group; Z represents a C
1
- to C
10
-alkyl diradical, optionally interrupted by a heteroatom, an aromatic or heteroaromatic diradical, optionally substituted with a hydroxy group, a C
1
- to C
6
-alkyl group and/or is subjected to a benzocondensation once or twice; or Z is —Ar(Alk)
n
—Ar—, wherein Ar represents an arylene group or a heteroarylene group, Alk represents a —CH
2
— group and n is 0 to 6; and x and y are 0 or 1.
新的二氨基吡唑化合物是桥联的4,5-二氨基吡唑化合物或其盐。这些二氨基吡唑化合物的化学式为（I）：其中R1代表氢、C1至C6烷基、C1至C4羟基烷基、C1至C4氨基烷基、C1至C8烷基氨基、双（C1至C8烷基）氨基、C1至C4烷基氨基（C1至C4烷基）、双（C1至C4烷基氨基）-C1至C4烷基、芳基或杂芳基；R2和R3各自代表氢、直链或支链的C1至C6烷基、芳基、杂芳基、羧酸、羧酸酯、未取代或取代的羧酸酰胺、羟基或C1至C4羟基烷基，或者R2和R3一起代表C1至C6烷基烯基；Z代表C1至C10烷基二基团，可由杂原子中断，芳香或杂芳二基团，可取代一个羟基、一个C1至C6烷基团和/或经过一次或两次苯环缩合；或Z为—Ar(Alk)n—Ar—，其中Ar代表芳基团或杂芳基团，Alk代表—CH2—基团，n为0至6；x和y为0或1。
![N-[2-(2-羟基乙氧基)-4-硝基苯基]乙醇胺化学式](data:image/svg+xml;base64,<?xml version="1.0" encoding="UTF-8"?>
<svg xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink" width="300" height="300" viewBox="0 0 300 300">
<defs>
<g>
<g id="glyph-0-0">
<path d="M 0.859375 3.03125 L 0.859375 -12.078125 L 9.421875 -12.078125 L 9.421875 3.03125 Z M 1.8125 2.078125 L 8.46875 2.078125 L 8.46875 -11.109375 L 1.8125 -11.109375 Z M 1.8125 2.078125 "/>
</g>
<g id="glyph-0-1">
<path d="M 6.75 -11.34375 C 5.519531 -11.34375 4.546875 -10.882812 3.828125 -9.96875 C 3.109375 -9.050781 2.75 -7.804688 2.75 -6.234375 C 2.75 -4.660156 3.109375 -3.414062 3.828125 -2.5 C 4.546875 -1.582031 5.519531 -1.125 6.75 -1.125 C 7.976562 -1.125 8.945312 -1.582031 9.65625 -2.5 C 10.375 -3.414062 10.734375 -4.660156 10.734375 -6.234375 C 10.734375 -7.804688 10.375 -9.050781 9.65625 -9.96875 C 8.945312 -10.882812 7.976562 -11.34375 6.75 -11.34375 Z M 6.75 -12.703125 C 8.5 -12.703125 9.894531 -12.113281 10.9375 -10.9375 C 11.988281 -9.769531 12.515625 -8.203125 12.515625 -6.234375 C 12.515625 -4.265625 11.988281 -2.691406 10.9375 -1.515625 C 9.894531 -0.335938 8.5 0.25 6.75 0.25 C 4.988281 0.25 3.582031 -0.332031 2.53125 -1.5 C 1.488281 -2.675781 0.96875 -4.253906 0.96875 -6.234375 C 0.96875 -8.203125 1.488281 -9.769531 2.53125 -10.9375 C 3.582031 -12.113281 4.988281 -12.703125 6.75 -12.703125 Z M 6.75 -12.703125 "/>
</g>
<g id="glyph-0-2">
<path d="M 1.6875 -12.484375 L 3.953125 -12.484375 L 9.484375 -2.046875 L 9.484375 -12.484375 L 11.125 -12.484375 L 11.125 0 L 8.859375 0 L 3.3125 -10.4375 L 3.3125 0 L 1.6875 0 Z M 1.6875 -12.484375 "/>
</g>
<g id="glyph-0-3">
<path d="M 1.6875 -12.484375 L 3.375 -12.484375 L 3.375 -7.359375 L 9.5 -7.359375 L 9.5 -12.484375 L 11.203125 -12.484375 L 11.203125 0 L 9.5 0 L 9.5 -5.9375 L 3.375 -5.9375 L 3.375 0 L 1.6875 0 Z M 1.6875 -12.484375 "/>
</g>
</g>
</defs>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.736173 3.520519 L 0.871135 3.02234 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.569444 3.616797 L 0.871043 3.214621 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.736173 3.510846 L 1.736173 4.530202 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.727777 3.525265 L 2.327436 3.180856 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.879622 3.017503 L -0.0043982 3.525265 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.871226 3.032105 L 0.866663 2.275846 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.744386 4.515783 L 0.871135 5.024731 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.577748 4.420053 L 0.871043 4.831902 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 2.87964 3.179487 L 3.478752 3.520246 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.00399757 3.510846 L 0.00399757 4.530202 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.170635 3.607306 L 0.170635 4.43429 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.119084 1.868834 L 1.730424 1.506356 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.879439 5.029568 L -0.00430694 4.515783 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.871135 5.015149 L 0.871135 5.770039 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 3.462143 3.520337 L 4.341965 3.006643 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.72221 1.520774 L 1.717191 0.498498 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.574636 6.100029 L 0.234425 6.295322 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 0.65759 6.244582 L 0.31747 6.439875 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.084314 6.245312 L 1.418776 6.43878 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.167724 6.101033 L 1.502186 6.2945 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 4.325265 3.006735 L 4.923554 3.34795 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<path fill="none" stroke-width="0.0333333" stroke-linecap="butt" stroke-linejoin="miter" stroke="rgb(0%, 0%, 0%)" stroke-opacity="1" stroke-miterlimit="10" d="M 1.708978 0.512917 L 2.298781 0.162941 " transform="matrix(42.804287, 0, 0, 42.804287, 33.242949, 10.330115)"/>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="137.941406" y="145.933594"/>
</g>
<g fill="rgb(19%, 31%, 97.000003%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="63.867188" y="103.007812"/>
</g>
<g fill="rgb(19%, 31%, 97.000003%)" fill-opacity="1">
<use xlink:href="#glyph-0-3" x="52.929688" y="103.007812"/>
</g>
<g fill="rgb(19%, 31%, 97.000003%)" fill-opacity="1">
<use xlink:href="#glyph-0-2" x="64.128906" y="274.503906"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="26.503906" y="295.902344"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="100.820313" y="295.902344"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="249.078125" y="166.613281"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-3" x="261.339844" y="166.386719"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-1" x="136.65625" y="16.5625"/>
</g>
<g fill="rgb(100%, 5.1%, 5.1%)" fill-opacity="1">
<use xlink:href="#glyph-0-3" x="148.917969" y="16.335938"/>
</g>
</svg>
)
