7-hydroxy-3-(naphthalen-1-yl)-2-(trifluoromethyl)-4H-chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 7-hydroxy-3-(naphthalen-1-yl)-2-(trifluoromethyl)-4H-chromen-4-one
• 英文别名: 7-hydroxy-3-naphthalen-1-yl-2-(trifluoromethyl)chromen-4-one
• 化学式: C₂₀H₁₁F₃O₃
• 分子量: 356.3
• InChiKey: ZDCZVPAWKQQXKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  26
• 可旋转键数：
  1
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• Arf6 inhibitors and methods of synthesis and use thereof
  申请人：Navigen, Inc.

  公开号：US10849901B2

  公开（公告）日：2020-12-01

  Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.

  本文公开了抑制 Arf6 的化合物和方法。本文还公开了用 Arf6 抑制剂治疗受试者的药物组合物和方法。
• ARF6 INHIBITORS AND METHODS OF SYNTHESIS AND USE THEREOF
  申请人：Navigen, Inc.

  公开号：US20170189405A1

  公开（公告）日：2017-07-06

  Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.
• [EN] ARF6 INHIBITORS AND METHODS OF SYNTHESIS AND USE THEREOF<br/>[FR] INHIBITEURRS D'ARF6 ET LEURS MÉTHODES DE SYNTHÈSE ET D'UTILISATION
  申请人：NAVIGEN INC

  公开号：WO2015183989A1

  公开（公告）日：2015-12-03

  Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.