6,7-Dihydroxy-3-(3-hydroxyphenyl)chromen-4-one

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 异黄酮类化合物
• 英文名称: 6,7-Dihydroxy-3-(3-hydroxyphenyl)chromen-4-one
• 化学式: C₁₅H₁₀O₅
• 分子量: 270.24
• InChiKey: UUYJBFPLBCYAAF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  20
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Isoflavones for regulating sirtuin gene expression
  申请人：Nestec S.A.

  公开号：EP2898923A2

  公开（公告）日：2015-07-29

  The invention provides compositions useful for regulating sirtuin gene expression, mimicking caloric restriction, preventing and treating Alzheimer's disease, increasing longevity and retarding aging in an animal. The compositions comprising one or more isoflavones are to be administered to the animals, preferably in amounts of from about 0.001 to about 10 g/kg/day.

  本发明提供了可用于调节 sirtuin 基因表达、模拟热量限制、预防和治疗阿尔茨海默病、延长动物寿命和延缓衰老的组合物。包含一种或多种异黄酮的组合物将施用给动物，优选用量为约 0.001 至约 10 克/千克/天。
• METHODS AND COMPOSITIONS SUITABLE FOR PREVENTING AND TREATING HYPERLEPTINEMIA
  申请人：Nestec S.A.

  公开号：EP2699095A2

  公开（公告）日：2014-02-26
• METHODS FOR REGULATING SIRTUIN GENE EXPRESSION
  申请人：Pan Yuanlong

  公开号：US20140039047A1

  公开（公告）日：2014-02-06

  The invention provides methods useful for regulating sirtuin gene expression, mimicking caloric restriction, preventing and treating Alzheimer's disease, increasing longevity and retarding aging in an animal. The methods comprise administering one or more isoflavones to the animals, preferably in amounts of from about 0.001 to about 10 g/kg/day.
• [EN] METHODS AND COMPOSITIONS SUITABLE FOR PREVENTING AND TREATING HYPERLEPTINEMIA<br/>[FR] MÉTHODES ET COMPOSITIONS POUVANT ÊTRE UTILISÉES POUR PRÉVENIR ET TRAITER L'HYPERLEPTINÉMIE
  申请人：NESTEC SA

  公开号：WO2012145281A2

  公开（公告）日：2012-10-26

  The invention provides methods and compositions suitable for preventing and treating hyperleptinemia, preventing and treating insulin resistance, preventing and treating cardiovascular disease, preventing and treating obesity, preventing and treating hyperlipidemia, and preventing and treating hypertension in an animal. The methods comprise administering one or more isoflavones to the animal, preferably in amounts of from about 0.001 to about 10 g/kg/day.