6-Benzyloxy-9-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-fluoro-9H-purine | 144640-77-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷
• 英文名称: 6-Benzyloxy-9-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-fluoro-9H-purine
• CAS: 144640-77-7
• 化学式: C₂₉H₄₅FN₄O₄Si₂
• 分子量: 588.87
• InChiKey: AYIXWKGFOKFLAS-YTFSRNRJSA-N

反应信息

• 作为反应物：
  描述：

  6-Benzyloxy-9-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-fluoro-9H-purine 在 palladium on activated charcoal 2,6-二甲基吡啶 、 六甲基二硅氧烷 、 氢气 作用下， 以 二甲基亚砜 为溶剂， 90.0 ℃ 、101.33 kPa 条件下， 反应 6.58h， 生成 Acetic acid (3S,4S)-4-{9-[(2R,4S,5R)-4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-ylamino}-1,2,3,4-tetrahydro-phenanthren-3-yl ester
  参考文献：
  名称：

  Epoxide and diol epoxide adducts of polycyclic aromatic hydrocarbons at the exocyclic amino group of deoxyguanosine

  摘要：

  Synthesis and separation of the diastereomeric trans N2-2'-deoxyguanosine adducts of tetrahydrophenanthrene 3,4-epoxide and benzo[a]pyrene 7,8-diol 9, 10-epoxide (benzylic hydroxyl group and epoxide oxygen trans), as well as the incorporation of the former into the pentanucleotide TpApG*pApT, are described.

  DOI：

  10.1016/s0040-4039(00)92649-2