| 1252807-57-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• CAS: 1252807-57-0
• 化学式: C₁₉H₁₇NO₃
• 分子量: 307.349
• InChiKey: SQLXYRKEONPXKE-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

  摘要：

  The SAR study of a series of 6-aryloxymethyl-8-aryl substituted quinolines is described. Optimization of the series led to the discovery of compound 26b, a highly potent (IC(50) = 0.6 nM) and selective PDE4D inhibitor with a 75-fold selectivity over the A, B, and C subtypes and over 18,000-fold selectivity against other PDE family members. Rat pharmacokinetics and tissue distribution are also summarized. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.076
• 作为产物：
  描述：

  ethyl 8-bromoquinoline-6-carboxylate 、 3-甲氧基苯硼酸 在 Pd(dppf)Cl₂ 、 sodium carbonate 作用下， 以 乙醇 、 甲苯 为溶剂， 生成
  参考文献：
  名称：

  The discovery and synthesis of highly potent subtype selective phosphodiesterase 4D inhibitors

  摘要：

  The SAR study of a series of 6-aryloxymethyl-8-aryl substituted quinolines is described. Optimization of the series led to the discovery of compound 26b, a highly potent (IC(50) = 0.6 nM) and selective PDE4D inhibitor with a 75-fold selectivity over the A, B, and C subtypes and over 18,000-fold selectivity against other PDE family members. Rat pharmacokinetics and tissue distribution are also summarized. (c) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2010.07.076