| 1023955-46-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 异戊烯醇脂质
• CAS: 1023955-46-5
• 化学式: C₂₁H₃₃Cl
• 分子量: 320.946
• InChiKey: MWQNRWPWDWBAOQ-MQKPGIJDSA-N

反应信息

• 作为反应物：
  描述：

  在 tris(tetra-n-butylammonium) hydrogen pyrophosphate 作用下， 以 乙腈 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs

  摘要：

  Protein prenyl transferases have been a focus of anti-cancer drug discovery in recent years due to their roles in post-translational modi. cation of small GTP binding proteins. Attention is now turning to the development of GGTase I inhibitors. Here, we present the synthesis and biological evaluation of four GGPP analogs versus mammalian GGTase I and the discovery that 7-allyl GGPP is a surprisingly efficient GGTase I substrate. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.014
• 作为产物：
  描述：

  在 N-氯代丁二酰亚胺 、 二甲基硫 作用下， 以 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs

  摘要：

  Protein prenyl transferases have been a focus of anti-cancer drug discovery in recent years due to their roles in post-translational modi. cation of small GTP binding proteins. Attention is now turning to the development of GGTase I inhibitors. Here, we present the synthesis and biological evaluation of four GGPP analogs versus mammalian GGTase I and the discovery that 7-allyl GGPP is a surprisingly efficient GGTase I substrate. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.02.014