tetraethyl 1,4-phenylene-di(aminomethylphosphonate) | 93190-14-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物
• 英文名称: tetraethyl 1,4-phenylene-di(aminomethylphosphonate)
• 英文别名: 1,4-Bis--benzol
• CAS: 93190-14-8
• 化学式: C₁₆H₃₀N₂O₆P₂
• 分子量: 408.372
• InChiKey: FTWYDSZOCBNTFG-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  N-叔丁氧羰基-L-丙氨酸 、 tetraethyl 1,4-phenylene-di(aminomethylphosphonate) 在 氯甲酸乙酯 、 三乙胺 、 氢溴酸 作用下， 以 氯仿 、 溶剂黄146 为溶剂， 以65%的产率得到1,4-phenylene-di(N-L-alanylaminomethylphosphonate)
  参考文献：
  名称：

  1,4-Phenylene-di(N-l-alanylaminomethylphosphonate) a new diaminophosphonate peptide receptor for lysine and arginine

  摘要：

  New diaminophosphonate peptide receptor composed of two aminomethylphosphonic acid fragments attached to phenyl ring in para position was described. Intermolecular interactions between such host molecule and unprotected cationic forms of lysine and arginine (guest molecules) were studied by means of NMR spectroscopy and ESI-MS spectrometry in both methanol and water solutions. Unfortunately, no complexation induced shifts in NMR spectra were observed for these host-guest systems in water solution. However, the performed studies have shown that in methanol complexes in host to guest ratio of 1: 1 and 1:2 are formed and they precipitate from the solution, while in water 1: 1 complexes are only seen and supramolecular interactions between host and guest discovered using H-1- and P-31 NMR T-1 relaxation method suggest that they are present as ionic pairs in aqueous solution. The supramolecular studies were supported by DFT theoretical studies performed for free receptor and its molecular complexes with Lys and Arg. (c) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molstruc.2007.03.022
• 作为产物：
  描述：

  对苯二甲醛 、 亚磷酸二乙酯 在 碘 、 六甲基二硅氮烷 、 盐酸 、 水 、 sodium hydroxide 作用下， 以 水 为溶剂， 反应 3.5h， 以95%的产率得到tetraethyl 1,4-phenylene-di(aminomethylphosphonate)
  参考文献：
  名称：

  Molecular iodine: An efficient catalyst for the one-pot synthesis of primary 1-aminophosphonates

  摘要：

  A new and convenient procedure has been developed for the one-pot synthesis of different types of primary 1-aminophosphonates from aldehydes/ketones, HMDS and diethyl phosphite using I-2 as an inexpensive, non-toxic, non-metallic and readily available catalyst. These reactions proceeded under solvent-free conditions and produced the desired products in high yields.

  DOI：

  10.1007/bf03245883