4-fluoro-N-((9-ethyltetrazolo[1,5-a]quinolin-4-yl)methylene)benzeneamine | 1254693-33-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 4-fluoro-N-((9-ethyltetrazolo[1,5-a]quinolin-4-yl)methylene)benzeneamine
• CAS: 1254693-33-8
• 化学式: C₁₈H₁₄FN₅
• 分子量: 319.341
• InChiKey: OEUWLUWYGUPGFO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.73
• 重原子数：
  24.0
• 可旋转键数：
  3.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.11
• 拓扑面积：
  55.44
• 氢给体数：
  0.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-fluoro-N-((9-ethyltetrazolo[1,5-a]quinolin-4-yl)methylene)benzeneamine 、 亚磷酸三乙酯 在 三甲基氯硅烷 作用下， 以88%的产率得到diethyl (9-ethyltetrazolo[1,5-a]quinolin-4-yl)(4-fluorophenylamino)methylphosphonate
  参考文献：
  名称：

  Synthesis and In Vitro Antimicrobial Activity of New α-Aminophosphonates via Tetrazolo [1,5-a] Quinoline Derivatives

  摘要：

  A series of diethyl (4-fluorophenylamino) (substituted tetrazolo[1,5-a]quinolin-4-yl)methyl phosphonate derivatives has been synthesized for the first time from tetrazolo [1,5-a] quinoline derivatives. Elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly, microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426500903530867
• 作为产物：
  描述：

  9-ethyltetrazolo[1,5-a]quinoline-4-carbaldehyde 、 4-氟苯胺 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 以89%的产率得到4-fluoro-N-((9-ethyltetrazolo[1,5-a]quinolin-4-yl)methylene)benzeneamine
  参考文献：
  名称：

  Synthesis and In Vitro Antimicrobial Activity of New α-Aminophosphonates via Tetrazolo [1,5-a] Quinoline Derivatives

  摘要：

  A series of diethyl (4-fluorophenylamino) (substituted tetrazolo[1,5-a]quinolin-4-yl)methyl phosphonate derivatives has been synthesized for the first time from tetrazolo [1,5-a] quinoline derivatives. Elemental analysis, IR, 1H NMR, 13C NMR, and mass spectral data elucidated the structures of the all newly synthesized compounds. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram-negative Escherichia coli, and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. Significantly, microbiological behavior of these newly synthesized derivatives possesses significant antibacterial and antifungal activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file.

  DOI：

  10.1080/10426500903530867